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without treatment&#44; at least 50&#37; of eyes with severe ROP will suffer serious and permanent visual loss&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Recent studies show that in the last 20 years the number of children requiring monitoring has risen constantly&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;7</span></a> Advances in neonatal care enable very low weight newborns to survive&#59; low weight and gestational age are associated with a higher incidence of severe ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8&#8211;10</span></a> The incidence of the disorder in developed countries varies compared to developing countries&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> partly due to greater use of assisted conception&#44; 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binocular indirect ophthalmoscopy &#40;BIO&#41;&#44; has serious limitations&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The examiner&#39;s interpretations are transcribed onto ophthalmological examination sheets&#44; where the interpretation is assumed to be correct and cannot be revised&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Another worrying factor is the shortage of trained ophthalmologists capable of performing examinations for diagnosis of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;10</span></a> As a result&#44; a large number of untrained ophthalmologists are carrying out screening and treatment of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;16&#44;17</span></a> Several studies show that inexperienced ophthalmologists are less skilled than trained ophthalmologists at identifying clinically significant ROP by analysing digital images&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;17&#44;18</span></a> Because of the shortage of trained ophthalmologists&#44; long delays can occur in screening&#59; another alternative is for the infants to be transferred&#44; with the considerable cost this entails and the potential risk to which the premature baby is subjected&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Telemedicine makes it possible to capture images and send them for subsequent interpretation by a remote expert&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> thereby solving many of the limitations in diagnosis of ROP performed by means of the &#8220;gold standard&#8221;&#46; By using wide-angle cameras&#44; telemedicine has demonstrated high precision and reliability in the diagnosis of ROP&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;19&#8211;26</span></a> and may be more cost-effective than the current method of diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;27</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The main objectives of this study are&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">To assess the reliability of diagnosis of ROP through ocular fundus images obtained with a RetCam 3 mobile retinal camera &#40;Clarity Medical Systems Inc&#46;&#41; via telemedicine&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">To explore the variability in diagnosis of ROP according to the training profile of the evaluator&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">This study followed the principles of the Helsinki Declaration and was approved by the Ethics Committee of the Hospital Cl&#237;nico San Carlos and the Hospital Universitario La Paz in Madrid&#46; All the parents of the preterm infants at risk of ROP who participated in the study signed an informed consent document&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0045" class="elsevierStylePara elsevierViewall">Digital images were taken of children at risk of ROP admitted to the neonatal intensive care unit &#40;NICU&#41; of the Hospital Universitario La Paz in Madrid&#46; The screening criterion applied was that laid down in the NICU protocol&#44; which includes all infants with a gestational age of less than 31 weeks &#40;&#8804;30<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; those of less than 34 weeks &#40;31&#8211;33&#41; with unstable clinical course or a weight of less than 1250<span class="elsevierStyleHsp" style=""></span>g&#46; Thirty retinal photographs were captured &#40;15 right eyes and 15 left eyes&#41; of 9 preterm infants between January 2012 and April 2012&#46; A total of 24 preterm infants were examined&#44; but only the cases with ROP were included in the study&#46; Excluded from the study were the preterm infants who&#44; in the neonatologist&#39;s opinion&#44; had an unstable clinical evolution and those whose retinopathy had previously been treated by laser&#46; In three low birth-weight preterm infant the initial examination could not be performed owing to the poor quality of the images obtained&#44; two of them because of corneal oedema and one because of insufficient pupillary dilation&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Schedule of care</span><p id="par0050" class="elsevierStylePara elsevierViewall">The first ocular fundus examination is carried out at the age of 4 weeks for newborns with a gestational age at birth of 27 weeks or more&#46; For newborns with a gestational age of less than 27 weeks&#44; the first examination is performed at the postmenstrual age of 31 weeks&#46; Depending on the results found in the ocular fundus exploration by BIO&#44; the scheduling of the follow-up examinations will adhere to the guidelines published by the Academy of Paediatrics&#44; the American Association for Paediatric Ophthalmology and Strabismus and the American Academy of Ophthalmology&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> The check-ups are continued until &#40;a&#41; the retina is fully vascularised&#59; &#40;b&#41; the vessels reach zone III without previous ROP in zone I or II &#40;a confirmatory examination would be indicated in very low-weight infants&#41; or &#40;c&#41; absence of &#8220;pre-threshold&#8221; disease by 45 weeks post-conceptional age &#40;zone I&#58; any stage with plus&#44; stage 3 without plus&#59; zone II&#58; stage 2 &#8220;plus&#8221; or stage 3&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Examination techniques</span><p id="par0055" class="elsevierStylePara elsevierViewall">Pupillary dilation is necessary to perform an ophthalmological examination&#46; Mydriasis is achieved by instillation of one drop of cyclopentolate 0&#46;25&#37; and one drop of phenylephrine 1&#37; 1<span class="elsevierStyleHsp" style=""></span>h before the examination&#44; repeated after 10<span class="elsevierStyleHsp" style=""></span>min&#46; The presence or absence of ROP&#44; its location&#44; its extent and plus disease were documented according to the criteria established in the International Classification of ROP&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> During the ophthalmological examination a nurse immobilises the premature infant and monitors his or her vital signs&#59; if there is any sudden alteration in the low birth-weight preterm infant cardiorespiratory indicators the examination is interrupted until the infant stabilises&#46; To avoid retinal phototoxicity&#44; ambient lighting is kept to a minimum and the lowest light intensity that allows a reliable examination is used in the ophthalmoscope&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Indirect ophthalmoscopic examination &#40;the &#8220;gold standard&#8221;&#41; was performed by a paediatric ROP-expert ophthalmologist&#46; The eyelids are kept open with special blepharostats for premature infants&#46; Viewing of the peripheral retina is carried out using scleral indentation and a 28-D lens&#46; Immediately after the BIO examination&#44; the same ophthalmologist and a technician specialising in capture of digital images &#40;Certificate of Completion&#46; Training Module Series&#58; RetCam Practice&#44; Ocular Anatomy and Imaging ROP Presented by Clarity Medical Systems Inc&#46;&#44; Pleasanton&#44; CA&#41; captured the images of each eye using the RetCam 3 wide-angle camera &#40;Clarity Medical Systems&#44; Pleasanton&#44; CA&#44; USA&#41; equipped with a special 130&#176; lens for premature infants&#46; In the methodology employed the ophthalmologist holds the camera while the technician controls the lighting and focus&#46; A minimum of 3 photos per eye was captured &#40;posterior pole&#44; nasal retina and temporal retina&#41;&#59; a group of images of the same eye in the same session was called a &#8220;set&#8221;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Reading and coding of digital images</span><p id="par0065" class="elsevierStylePara elsevierViewall">The retinal photographs obtained were sent to the storage centre&#44; where they were coded&#46; A total of 30 sets were interpreted independently by 3 masked groups&#58; group A&#44; comprising 8 ophthalmologists &#40;3 anterior pole surgeons&#44; 3 retinologists&#44; and 2 general ophthalmologists&#41;&#59; group B&#44; composed of 5 vision experts from the Universidad Complutense in Madrid &#40;graduates with official master&#39;s degrees in optics&#44; optometry and vision&#41; and group C&#44; consisting of 2 ophthalmologist experts in diagnosis and treatment of ROP&#46; Groups A and B were informed about the diagnosis of ROP by means of a 4-page guide compiled by the authors&#46; All those surveyed were asked about the diagnosis of ROP&#59; each set of photos was classified by ROP&#44; stage&#44; zone&#44; plus&#44; referral to paediatric ophthalmologist &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#41; and observations&#46; The interpretation of the retinal photographs was based on the criteria laid down in the study <span class="elsevierStyleItalic">Early Treatment for Retinopathy of Prematurity</span> &#40;ETROP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> The images transmitted were coded at the storage centre and classified using a system of 4 levels&#44; as in the study by Myung et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#40;1&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 1 ROP&#58;</span> zone I&#44; any stage with plus disease or stage 3 without plus disease&#59; zone II&#44; stages 2 or 3 with plus disease&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#40;2&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 2 ROP&#58;</span> zone I&#44; stages 1 or 2 without plus disease&#59; zone II&#44; stage 3 without plus disease&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#40;3&#41;</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Moderate ROP&#58;</span> defined as ROP less severe than type 2&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#40;4&#41;</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">No ROP</span>&#46;</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">No time limit was set for interpreting the images&#46; The diagnosis and recommendations for control examinations were returned by email to the storage centre&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Analysis of data</span><p id="par0095" class="elsevierStylePara elsevierViewall">The validity of the new diagnosis system was determined by comparing the results obtained by the three groups&#44; and the diagnosis performed using BIO by a paediatric ophthalmologist specialising in ROP was taken as a reference&#46; The results obtained with BIO and RetCam for each set were collected in separate columns using statistical software &#40;Microsoft Excel 2010&#44; Redmond&#44; WA&#44; USA&#41;&#46; The calculations for the statistical analysis were performed with SAS 9&#46;2 software&#46; Sensitivity&#44; specificity&#44; Kappa index and percent success rate of each group were calculated for detection of type 1 ROP and referral &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP&#41;&#46; We used ANOVA and Duncan&#39;s test to compare the results between groups&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 30 sets of images were analysed by 15 observers &#40;8 ophthalmologists&#44; 5 vision experts and 2 paediatric ophthalmologists specialising in ROP&#41;&#46; According to the diagnosis with BIO performed by the reference observer &#40;the &#8220;gold standard&#8221;&#41;&#44; 47&#37; of the digital images showed type 1 ROP&#44; 3&#37; type 2 ROP&#44; and 50&#37; moderate ROP&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows sensitivity&#44; specificity&#44; Kappa index and percent agreement in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 &#40;referral&#41; by group C&#44; comprising two ophthalmologists expert in the diagnosis of ROP&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#tbl0010">Tables 2 and 3</a> show sensitivity&#44; specificity&#44; Kappa index and percent agreement in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 &#40;referral&#41; by three groups of specialists compared with the reference diagnosis performed by a paediatric ROP-expert ophthalmologist&#46; Sensitivity&#44; Kappa index and percent success rate were statistically significant in group C for diagnosis of type 1 ROP&#46; In the diagnosis of type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP the Kappa index and percent success rate were statistically significant&#44; producing higher values in group C&#46; No statistically significant differences were found between groups A and B in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">The results of this study confirm&#44; firstly&#44; the efficacy of the RetCam 3 wide-angle camera through images obtained by trained staff&#46; In addition&#44; the study demonstrates the viability of telemedicine for the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP &#40;referral&#41; when performed by paediatric ROP-expert ophthalmologists&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The viability of telemedicine in the assessment of low birth-weight preterm infant is a point of great interest given the gradually increasing number of children at risk of ROP<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8</span></a> in developed countries&#46; Digital images offer an innovative strategy for detecting infants with severe ROP&#44;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> and several studies show excellent sensitivity and specificity in the diagnosis of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;18&#8211;20&#44;24&#44;25&#44;33&#8211;36</span></a> In most research studies an ophthalmologist<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;19&#44;26&#44;32&#44;33&#44;36&#8211;38</span></a> or a nurse<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;21&#44;22&#44;25&#44;34&#44;35&#44;39&#44;40</span></a> carried out the test&#44; although occasionally an ophthalmological photographer<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;20&#44;23</span></a> obtained the images&#46; Our conclusions coincide with the results published by Skalet et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> in which two trained nurses captured the images with the NIDEK NM200-D camera and subsequently sent them to five ROP experts&#46; The conclusions of Skalet et al&#46; show that images obtained by trained staff and sent to specialists can be useful for identifying infants who require evaluation by a ROP-expert ophthalmologist&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In 2008 Kemper et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> showed that there was a high proportion of untrained ophthalmologists carrying out screening and treatment of ROP&#46; Moreover&#44; Paul Chan et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> in 2010&#44; assessed the reliability of inexperienced ophthalmologists in the diagnosis of ROP&#59; they demonstrated a clinically significant underestimation of ROP&#44; which raises important questions about the quality of ROP screening performed by non-expert ophthalmologists&#46; We therefore agree with the suggestion of Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> that an ophthalmologists&#8217; training should include a minimum number of ROP examinations and treatments&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The results of this research are similar to those obtained in the study by Myung et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> which shows a sensitivity of approximately 50&#37; in the detection of type 1 and type 2 ROP by paediatric ophthalmologists inexperienced in ROP&#59; it is equivalent&#44; in this study&#44; to the sensitivity in referral &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#41; of groups A and B&#44; consisting of non-ROP experts&#46; The results also coincide for type 1 ROP&#44; where low sensitivity and high specificity were obtained in groups A and B&#46; Unlike the study by Myung et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> in which the diagnosis made by a paediatric retina expert using digital images is taken as a reference&#44; the &#8220;gold standard&#8221; used here is the diagnosis obtained using indirect ophthalmoscopy performed by an expert in ROP&#44; following the recommendations of the Section on Ophthalmology of the American Academy of Pediatrics&#44; the American Academy of Ophthalmology and the American Association for Pediatric Ophthalmology and Strabismus&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The advantages of telemedicine have already been described by several authors&#46; It has been shown to be reliable for the diagnosis of ROP and to save costs compared with the conventional method of diagnosis&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> but this is not enough&#59; the opinion of the parents must be taken into account&#46; The research of Lee<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> concludes that parents have a positive impression of ROP diagnosis by telemedicine&#44; but express a preference for face-to-face contact&#46; The current benefits of new technologies are indisputable&#44; but it should not be forgotten that information must be as widely available as possible&#44; both to patients and to those accompanying them&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In our review of the literature we found few studies that evaluated the training of ophthalmologists who carry out the examination&#44; assessment and treatment of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;16&#8211;18</span></a> As has been shown&#44; differences in the diagnosis of ROP lead to different outcomes of the disease&#44; and therefore future research should propose a minimum number of examinations for untrained ophthalmologists&#46; We also wish to highlight the potential risk involved in untrained staff carrying out the diagnosis and treatment of ROP&#46; This study found no significant differences in the results between ophthalmologists &#40;group A&#41; and vision experts &#40;group B&#41;&#46; Future projects could analyse the role of opticians and optometrists for screening of ROP&#44; which would save the cost of transferring the premature infant and avoid having specialists perform the test&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We recognise that one of the limitations of this study is the number of premature infants examined and the small number of experts performing the diagnosis of ROP&#46; In this phase&#44; only retinal photographs of premature infants with some stage of retinopathy were captured&#46; This was done to avoid the stress for the infant caused by the additional test with the RetCam&#46; Future research could be conducted&#44; as in the study by Skarlet et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> with several experts on premature infants&#44; comparing them with a series of ophthalmologists without experience of ROP&#46; As in previous studies&#44; the principal limitations were the assessment of zone III and the quality of the images&#59;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> in particular&#44; serious difficulties were encountered in the examination of patients with CPAP both by BIO and by RetCam&#59; the view of the retina is slightly better with digital images&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; use of the RetCam 3 mobile retinal camera by ophthalmologist experts in ROP has proved to be reliable for diagnosis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The retinopathy of prematurity &#40;ROP&#41; is a potentially avoidable cause of blindness in children&#46; The advances in neonatal care make the survival of extremely premature infants&#44; who show a greater incidence of the disease&#44; possible&#46; The aim of the study is to evaluate the reliability of ROP screening using retinography imaging with the RetCam 3 wide-angle camera and also to study the variability of ROP diagnosis depending on the evaluator&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The indirect ophthalmoscopy exam was performed by a paediatric ROP-expert ophthalmologist&#46; The same ophthalmologist and a technician specialised in digital image capture took retinal images using the RetCam 3 wide-angle camera&#46; A total of 30 image sets were analysed by 3 masked groups&#58; group A &#40;8 ophthalmologists&#41;&#44; group B &#40;5 experts in vision&#41;&#44; and group C &#40;2 ROP-expert ophthalmologists&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">According to the diagnosis using indirect ophthalmoscopy&#44; the sensitivity &#40;26&#8211;93&#41;&#44; Kappa &#40;0&#46;24&#8211;0&#46;80&#41;&#44; and the percentage agreement were statistically significant in group C for the diagnosis of ROP type 1&#46; In the diagnosis of ROP type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#44; Kappa &#40;0&#46;17&#8211;0&#46;33&#41; and the percentage agreement &#40;58&#8211;90&#41; were statistically significant&#44; with higher values in group C&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The diagnosis&#44; carried out by ROP-expert ophthalmologists&#44; using the wide-angle camera RetCam 3 has proven to be a reliable method&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La retinopat&#237;a del prematuro &#40;ROP&#41; es una de las principales causas de ceguera infantil potencialmente evitable&#46; Los avances en los cuidados neonatales consiguen la supervivencia de ni&#241;os de bajo peso extremo asociado con una mayor incidencia de la enfermedad&#46; El objetivo de este estudio es evaluar la fiabilidad en el diagn&#243;stico de la ROP a trav&#233;s de retinograf&#237;as obtenidas con la c&#225;mara de campo amplio RetCam 3 y estudiar la variabilidad en el diagn&#243;stico de ROP en funci&#243;n del evaluador&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El examen con oftalmoscopio indirecto fue realizado por un oftalm&#243;logo pedi&#225;trico experto en ROP&#46; Las im&#225;genes retinianas fueron obtenidas por el mismo oftalm&#243;logo y un t&#233;cnico especializado en la captura de im&#225;genes digitales&#46; Un total de 30<span class="elsevierStyleHsp" style=""></span>sets de im&#225;genes fueron analizados por 3 grupos enmascarados&#58; grupo A &#40;8 oftalm&#243;logos&#41;&#44; grupo<span class="elsevierStyleHsp" style=""></span>B &#40;5 expertos en visi&#243;n&#41; y grupo <span class="elsevierStyleSmallCaps">C</span> &#40;2 oftalm&#243;logos expertos en ROP&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acorde con el diagn&#243;stico mediante oftalmoscopia indirecta&#44; la sensibilidad &#40;26-93&#41;&#44; el &#237;ndice Kappa &#40;0&#44;24-0&#44;80&#41; y el porcentaje de aciertos fueron estad&#237;sticamente significativos en el grupo<span class="elsevierStyleHsp" style=""></span>C para el diagn&#243;stico de ROP tipo<span class="elsevierStyleHsp" style=""></span>1&#46; En el diagn&#243;stico de ROP tipo<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>tipo<span class="elsevierStyleHsp" style=""></span>2 el &#237;ndice Kappa &#40;0&#44;17-0&#44;33&#41; y el porcentaje de aciertos &#40;58-90&#41; fueron estad&#237;sticamente significativos&#44; obteniendo valores superiores en el grupo C&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico realizado por oftalm&#243;logos expertos en ROP con el retin&#243;grafo m&#243;vil RetCam 3 ha demostrado ser un m&#233;todo fiable&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Navarro-Blanco C&#44; Peralta-Calvo J&#44; Pastora-Salvador N&#44; &#193;lvarez-Rementer&#237;a L&#44; Chamorro E&#44; S&#225;nchez-Ramos C&#46; Fiabilidad en el cribado de la retinopat&#237;a del prematuro mediante el an&#225;lisis de retinograf&#237;as&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;81&#58;149&#8211;154&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
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        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sensitivity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Specificity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Kappa &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CD &#40;&#37;&#41; &#40;maximum&#8211;minimum&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Type 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;80 &#40;0&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">88 &#40;95&#8211;81&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">90 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;80 &#40;0&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90 &#40;95&#8211;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              ]
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        "etiqueta" => "Table 2"
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        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Type 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sensitivity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Specificity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Kappa &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;24 &#40;0&#46;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;68&#8211;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;29 &#40;0&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;65&#8211;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;80 &#40;0&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;95&#8211;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Value of <span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0114<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6944&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0046<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0053<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              ]
              "imagenFichero" => array:1 [
                0 => "xTab556686.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Group C different from the other groups&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Sensitivity&#44; specificity&#44; Kappa index and percent agreement for diagnosis of type 1 ROP by 3 groups of specialists compared with the reference diagnosis performed by a paediatric ROP-expert ophthalmologist&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">CD&#44; correct diagnoses&#46;</p>"
          "tablatextoimagen" => array:1 [
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sensitivity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Specificity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Kappa &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CD &#40;&#37;&#41; &#40;maximum&#8211;minimum&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                      "titulo" => "Characteristics of infants with severe retinopathy of prematurity in countries with low&#44; moderate&#44; and high levels of development&#58; implications for screening programs"
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                        0 => array:2 [
                          "etal" => true
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                            4 => "R&#46; Semiglia"
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                          "autores" => array:4 [
                            0 => "I&#46; Casteels"
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                          "etal" => true
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Original Article
Reliability of retinal imaging screening in retinopathy of prematurity
Fiabilidad en el cribado de la retinopatía del prematuro mediante el análisis de retinografías
C. Navarro-Blancoa,b,
Corresponding author
, J. Peralta-Calvoc, N. Pastora-Salvadorc, L. Álvarez-Rementeríab, E. Chamorroa, C. Sánchez-Ramosa
a Grupo de Neuro-Computación y Neuro-Robótica, Universidad Complutense de Madrid, Madrid, Spain
b Departamento de Oftalmología, Clínica Rementería, Madrid, Spain
c Departamento de Oftalmología Infantil, Hospital Universitario La Paz, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Despite advances in retinopathy of prematurity &#40;ROP&#41;&#44; this disorder is one of the main potentially avoidable causes of childhood blindness&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> ROP is a vasoproliferative retinopathy&#44; characterised by the presence of an immature and partially vascularised retina&#44; affecting low birth-weight preterm infants&#46; The spectrum of possible results for patients with ROP ranges from mild cases&#44; where the sequelae are minimal and do not affect vision&#44; to more aggressive&#44; bilateral cases&#44; with total and irreversible blindness&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Prompt intervention is critical to maximise the chance of a favourable outcome<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#59; without treatment&#44; at least 50&#37; of eyes with severe ROP will suffer serious and permanent visual loss&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Recent studies show that in the last 20 years the number of children requiring monitoring has risen constantly&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;7</span></a> Advances in neonatal care enable very low weight newborns to survive&#59; low weight and gestational age are associated with a higher incidence of severe ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8&#8211;10</span></a> The incidence of the disorder in developed countries varies compared to developing countries&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> partly due to greater use of assisted conception&#44; increasing maternal age&#44; possible genetic aetiologies and other socioeconomic issues&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Prevalence in Spain&#44; during the last decade and the beginning of the present one&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> was similar to that of other developed countries in the European Community and the United States&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;14</span></a> Currently&#44; according to the available data from the Instituto Nacional de Estad&#237;stica &#40;INE&#58; National Statistics Institute&#41;&#44; the number of newborns whose weight was less than 1500<span class="elsevierStyleHsp" style=""></span>g in Spain in 2011 was 4178&#44; of whom 682 were in the Autonomous Community of Madrid&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The current method of diagnosis&#44; binocular indirect ophthalmoscopy &#40;BIO&#41;&#44; has serious limitations&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The examiner&#39;s interpretations are transcribed onto ophthalmological examination sheets&#44; where the interpretation is assumed to be correct and cannot be revised&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Another worrying factor is the shortage of trained ophthalmologists capable of performing examinations for diagnosis of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;10</span></a> As a result&#44; a large number of untrained ophthalmologists are carrying out screening and treatment of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;16&#44;17</span></a> Several studies show that inexperienced ophthalmologists are less skilled than trained ophthalmologists at identifying clinically significant ROP by analysing digital images&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;17&#44;18</span></a> Because of the shortage of trained ophthalmologists&#44; long delays can occur in screening&#59; another alternative is for the infants to be transferred&#44; with the considerable cost this entails and the potential risk to which the premature baby is subjected&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Telemedicine makes it possible to capture images and send them for subsequent interpretation by a remote expert&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> thereby solving many of the limitations in diagnosis of ROP performed by means of the &#8220;gold standard&#8221;&#46; By using wide-angle cameras&#44; telemedicine has demonstrated high precision and reliability in the diagnosis of ROP&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;19&#8211;26</span></a> and may be more cost-effective than the current method of diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;27</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The main objectives of this study are&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">To assess the reliability of diagnosis of ROP through ocular fundus images obtained with a RetCam 3 mobile retinal camera &#40;Clarity Medical Systems Inc&#46;&#41; via telemedicine&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">To explore the variability in diagnosis of ROP according to the training profile of the evaluator&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">This study followed the principles of the Helsinki Declaration and was approved by the Ethics Committee of the Hospital Cl&#237;nico San Carlos and the Hospital Universitario La Paz in Madrid&#46; All the parents of the preterm infants at risk of ROP who participated in the study signed an informed consent document&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0045" class="elsevierStylePara elsevierViewall">Digital images were taken of children at risk of ROP admitted to the neonatal intensive care unit &#40;NICU&#41; of the Hospital Universitario La Paz in Madrid&#46; The screening criterion applied was that laid down in the NICU protocol&#44; which includes all infants with a gestational age of less than 31 weeks &#40;&#8804;30<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; those of less than 34 weeks &#40;31&#8211;33&#41; with unstable clinical course or a weight of less than 1250<span class="elsevierStyleHsp" style=""></span>g&#46; Thirty retinal photographs were captured &#40;15 right eyes and 15 left eyes&#41; of 9 preterm infants between January 2012 and April 2012&#46; A total of 24 preterm infants were examined&#44; but only the cases with ROP were included in the study&#46; Excluded from the study were the preterm infants who&#44; in the neonatologist&#39;s opinion&#44; had an unstable clinical evolution and those whose retinopathy had previously been treated by laser&#46; In three low birth-weight preterm infant the initial examination could not be performed owing to the poor quality of the images obtained&#44; two of them because of corneal oedema and one because of insufficient pupillary dilation&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Schedule of care</span><p id="par0050" class="elsevierStylePara elsevierViewall">The first ocular fundus examination is carried out at the age of 4 weeks for newborns with a gestational age at birth of 27 weeks or more&#46; For newborns with a gestational age of less than 27 weeks&#44; the first examination is performed at the postmenstrual age of 31 weeks&#46; Depending on the results found in the ocular fundus exploration by BIO&#44; the scheduling of the follow-up examinations will adhere to the guidelines published by the Academy of Paediatrics&#44; the American Association for Paediatric Ophthalmology and Strabismus and the American Academy of Ophthalmology&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> The check-ups are continued until &#40;a&#41; the retina is fully vascularised&#59; &#40;b&#41; the vessels reach zone III without previous ROP in zone I or II &#40;a confirmatory examination would be indicated in very low-weight infants&#41; or &#40;c&#41; absence of &#8220;pre-threshold&#8221; disease by 45 weeks post-conceptional age &#40;zone I&#58; any stage with plus&#44; stage 3 without plus&#59; zone II&#58; stage 2 &#8220;plus&#8221; or stage 3&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Examination techniques</span><p id="par0055" class="elsevierStylePara elsevierViewall">Pupillary dilation is necessary to perform an ophthalmological examination&#46; Mydriasis is achieved by instillation of one drop of cyclopentolate 0&#46;25&#37; and one drop of phenylephrine 1&#37; 1<span class="elsevierStyleHsp" style=""></span>h before the examination&#44; repeated after 10<span class="elsevierStyleHsp" style=""></span>min&#46; The presence or absence of ROP&#44; its location&#44; its extent and plus disease were documented according to the criteria established in the International Classification of ROP&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> During the ophthalmological examination a nurse immobilises the premature infant and monitors his or her vital signs&#59; if there is any sudden alteration in the low birth-weight preterm infant cardiorespiratory indicators the examination is interrupted until the infant stabilises&#46; To avoid retinal phototoxicity&#44; ambient lighting is kept to a minimum and the lowest light intensity that allows a reliable examination is used in the ophthalmoscope&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Indirect ophthalmoscopic examination &#40;the &#8220;gold standard&#8221;&#41; was performed by a paediatric ROP-expert ophthalmologist&#46; The eyelids are kept open with special blepharostats for premature infants&#46; Viewing of the peripheral retina is carried out using scleral indentation and a 28-D lens&#46; Immediately after the BIO examination&#44; the same ophthalmologist and a technician specialising in capture of digital images &#40;Certificate of Completion&#46; Training Module Series&#58; RetCam Practice&#44; Ocular Anatomy and Imaging ROP Presented by Clarity Medical Systems Inc&#46;&#44; Pleasanton&#44; CA&#41; captured the images of each eye using the RetCam 3 wide-angle camera &#40;Clarity Medical Systems&#44; Pleasanton&#44; CA&#44; USA&#41; equipped with a special 130&#176; lens for premature infants&#46; In the methodology employed the ophthalmologist holds the camera while the technician controls the lighting and focus&#46; A minimum of 3 photos per eye was captured &#40;posterior pole&#44; nasal retina and temporal retina&#41;&#59; a group of images of the same eye in the same session was called a &#8220;set&#8221;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Reading and coding of digital images</span><p id="par0065" class="elsevierStylePara elsevierViewall">The retinal photographs obtained were sent to the storage centre&#44; where they were coded&#46; A total of 30 sets were interpreted independently by 3 masked groups&#58; group A&#44; comprising 8 ophthalmologists &#40;3 anterior pole surgeons&#44; 3 retinologists&#44; and 2 general ophthalmologists&#41;&#59; group B&#44; composed of 5 vision experts from the Universidad Complutense in Madrid &#40;graduates with official master&#39;s degrees in optics&#44; optometry and vision&#41; and group C&#44; consisting of 2 ophthalmologist experts in diagnosis and treatment of ROP&#46; Groups A and B were informed about the diagnosis of ROP by means of a 4-page guide compiled by the authors&#46; All those surveyed were asked about the diagnosis of ROP&#59; each set of photos was classified by ROP&#44; stage&#44; zone&#44; plus&#44; referral to paediatric ophthalmologist &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#41; and observations&#46; The interpretation of the retinal photographs was based on the criteria laid down in the study <span class="elsevierStyleItalic">Early Treatment for Retinopathy of Prematurity</span> &#40;ETROP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> The images transmitted were coded at the storage centre and classified using a system of 4 levels&#44; as in the study by Myung et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#40;1&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 1 ROP&#58;</span> zone I&#44; any stage with plus disease or stage 3 without plus disease&#59; zone II&#44; stages 2 or 3 with plus disease&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#40;2&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 2 ROP&#58;</span> zone I&#44; stages 1 or 2 without plus disease&#59; zone II&#44; stage 3 without plus disease&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#40;3&#41;</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Moderate ROP&#58;</span> defined as ROP less severe than type 2&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#40;4&#41;</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">No ROP</span>&#46;</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">No time limit was set for interpreting the images&#46; The diagnosis and recommendations for control examinations were returned by email to the storage centre&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Analysis of data</span><p id="par0095" class="elsevierStylePara elsevierViewall">The validity of the new diagnosis system was determined by comparing the results obtained by the three groups&#44; and the diagnosis performed using BIO by a paediatric ophthalmologist specialising in ROP was taken as a reference&#46; The results obtained with BIO and RetCam for each set were collected in separate columns using statistical software &#40;Microsoft Excel 2010&#44; Redmond&#44; WA&#44; USA&#41;&#46; The calculations for the statistical analysis were performed with SAS 9&#46;2 software&#46; Sensitivity&#44; specificity&#44; Kappa index and percent success rate of each group were calculated for detection of type 1 ROP and referral &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP&#41;&#46; We used ANOVA and Duncan&#39;s test to compare the results between groups&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 30 sets of images were analysed by 15 observers &#40;8 ophthalmologists&#44; 5 vision experts and 2 paediatric ophthalmologists specialising in ROP&#41;&#46; According to the diagnosis with BIO performed by the reference observer &#40;the &#8220;gold standard&#8221;&#41;&#44; 47&#37; of the digital images showed type 1 ROP&#44; 3&#37; type 2 ROP&#44; and 50&#37; moderate ROP&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows sensitivity&#44; specificity&#44; Kappa index and percent agreement in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 &#40;referral&#41; by group C&#44; comprising two ophthalmologists expert in the diagnosis of ROP&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#tbl0010">Tables 2 and 3</a> show sensitivity&#44; specificity&#44; Kappa index and percent agreement in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 &#40;referral&#41; by three groups of specialists compared with the reference diagnosis performed by a paediatric ROP-expert ophthalmologist&#46; Sensitivity&#44; Kappa index and percent success rate were statistically significant in group C for diagnosis of type 1 ROP&#46; In the diagnosis of type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP the Kappa index and percent success rate were statistically significant&#44; producing higher values in group C&#46; No statistically significant differences were found between groups A and B in the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">The results of this study confirm&#44; firstly&#44; the efficacy of the RetCam 3 wide-angle camera through images obtained by trained staff&#46; In addition&#44; the study demonstrates the viability of telemedicine for the diagnosis of type 1 ROP and type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2 ROP &#40;referral&#41; when performed by paediatric ROP-expert ophthalmologists&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The viability of telemedicine in the assessment of low birth-weight preterm infant is a point of great interest given the gradually increasing number of children at risk of ROP<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8</span></a> in developed countries&#46; Digital images offer an innovative strategy for detecting infants with severe ROP&#44;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> and several studies show excellent sensitivity and specificity in the diagnosis of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;18&#8211;20&#44;24&#44;25&#44;33&#8211;36</span></a> In most research studies an ophthalmologist<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;19&#44;26&#44;32&#44;33&#44;36&#8211;38</span></a> or a nurse<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;21&#44;22&#44;25&#44;34&#44;35&#44;39&#44;40</span></a> carried out the test&#44; although occasionally an ophthalmological photographer<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;20&#44;23</span></a> obtained the images&#46; Our conclusions coincide with the results published by Skalet et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> in which two trained nurses captured the images with the NIDEK NM200-D camera and subsequently sent them to five ROP experts&#46; The conclusions of Skalet et al&#46; show that images obtained by trained staff and sent to specialists can be useful for identifying infants who require evaluation by a ROP-expert ophthalmologist&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In 2008 Kemper et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> showed that there was a high proportion of untrained ophthalmologists carrying out screening and treatment of ROP&#46; Moreover&#44; Paul Chan et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> in 2010&#44; assessed the reliability of inexperienced ophthalmologists in the diagnosis of ROP&#59; they demonstrated a clinically significant underestimation of ROP&#44; which raises important questions about the quality of ROP screening performed by non-expert ophthalmologists&#46; We therefore agree with the suggestion of Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> that an ophthalmologists&#8217; training should include a minimum number of ROP examinations and treatments&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The results of this research are similar to those obtained in the study by Myung et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> which shows a sensitivity of approximately 50&#37; in the detection of type 1 and type 2 ROP by paediatric ophthalmologists inexperienced in ROP&#59; it is equivalent&#44; in this study&#44; to the sensitivity in referral &#40;type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#41; of groups A and B&#44; consisting of non-ROP experts&#46; The results also coincide for type 1 ROP&#44; where low sensitivity and high specificity were obtained in groups A and B&#46; Unlike the study by Myung et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> in which the diagnosis made by a paediatric retina expert using digital images is taken as a reference&#44; the &#8220;gold standard&#8221; used here is the diagnosis obtained using indirect ophthalmoscopy performed by an expert in ROP&#44; following the recommendations of the Section on Ophthalmology of the American Academy of Pediatrics&#44; the American Academy of Ophthalmology and the American Association for Pediatric Ophthalmology and Strabismus&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The advantages of telemedicine have already been described by several authors&#46; It has been shown to be reliable for the diagnosis of ROP and to save costs compared with the conventional method of diagnosis&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> but this is not enough&#59; the opinion of the parents must be taken into account&#46; The research of Lee<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> concludes that parents have a positive impression of ROP diagnosis by telemedicine&#44; but express a preference for face-to-face contact&#46; The current benefits of new technologies are indisputable&#44; but it should not be forgotten that information must be as widely available as possible&#44; both to patients and to those accompanying them&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In our review of the literature we found few studies that evaluated the training of ophthalmologists who carry out the examination&#44; assessment and treatment of ROP&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;16&#8211;18</span></a> As has been shown&#44; differences in the diagnosis of ROP lead to different outcomes of the disease&#44; and therefore future research should propose a minimum number of examinations for untrained ophthalmologists&#46; We also wish to highlight the potential risk involved in untrained staff carrying out the diagnosis and treatment of ROP&#46; This study found no significant differences in the results between ophthalmologists &#40;group A&#41; and vision experts &#40;group B&#41;&#46; Future projects could analyse the role of opticians and optometrists for screening of ROP&#44; which would save the cost of transferring the premature infant and avoid having specialists perform the test&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We recognise that one of the limitations of this study is the number of premature infants examined and the small number of experts performing the diagnosis of ROP&#46; In this phase&#44; only retinal photographs of premature infants with some stage of retinopathy were captured&#46; This was done to avoid the stress for the infant caused by the additional test with the RetCam&#46; Future research could be conducted&#44; as in the study by Skarlet et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> with several experts on premature infants&#44; comparing them with a series of ophthalmologists without experience of ROP&#46; As in previous studies&#44; the principal limitations were the assessment of zone III and the quality of the images&#59;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> in particular&#44; serious difficulties were encountered in the examination of patients with CPAP both by BIO and by RetCam&#59; the view of the retina is slightly better with digital images&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; use of the RetCam 3 mobile retinal camera by ophthalmologist experts in ROP has proved to be reliable for diagnosis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2013-07-08"
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          "palabras" => array:5 [
            0 => "Retinopathy of prematurity"
            1 => "Preterm infants"
            2 => "Retinal image"
            3 => "Diagnostic imaging"
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            0 => "Retinopat&#237;a del prematuro"
            1 => "Reci&#233;n nacido pret&#233;rmino"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The retinopathy of prematurity &#40;ROP&#41; is a potentially avoidable cause of blindness in children&#46; The advances in neonatal care make the survival of extremely premature infants&#44; who show a greater incidence of the disease&#44; possible&#46; The aim of the study is to evaluate the reliability of ROP screening using retinography imaging with the RetCam 3 wide-angle camera and also to study the variability of ROP diagnosis depending on the evaluator&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The indirect ophthalmoscopy exam was performed by a paediatric ROP-expert ophthalmologist&#46; The same ophthalmologist and a technician specialised in digital image capture took retinal images using the RetCam 3 wide-angle camera&#46; A total of 30 image sets were analysed by 3 masked groups&#58; group A &#40;8 ophthalmologists&#41;&#44; group B &#40;5 experts in vision&#41;&#44; and group C &#40;2 ROP-expert ophthalmologists&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">According to the diagnosis using indirect ophthalmoscopy&#44; the sensitivity &#40;26&#8211;93&#41;&#44; Kappa &#40;0&#46;24&#8211;0&#46;80&#41;&#44; and the percentage agreement were statistically significant in group C for the diagnosis of ROP type 1&#46; In the diagnosis of ROP type 1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>type 2&#44; Kappa &#40;0&#46;17&#8211;0&#46;33&#41; and the percentage agreement &#40;58&#8211;90&#41; were statistically significant&#44; with higher values in group C&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The diagnosis&#44; carried out by ROP-expert ophthalmologists&#44; using the wide-angle camera RetCam 3 has proven to be a reliable method&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La retinopat&#237;a del prematuro &#40;ROP&#41; es una de las principales causas de ceguera infantil potencialmente evitable&#46; Los avances en los cuidados neonatales consiguen la supervivencia de ni&#241;os de bajo peso extremo asociado con una mayor incidencia de la enfermedad&#46; El objetivo de este estudio es evaluar la fiabilidad en el diagn&#243;stico de la ROP a trav&#233;s de retinograf&#237;as obtenidas con la c&#225;mara de campo amplio RetCam 3 y estudiar la variabilidad en el diagn&#243;stico de ROP en funci&#243;n del evaluador&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El examen con oftalmoscopio indirecto fue realizado por un oftalm&#243;logo pedi&#225;trico experto en ROP&#46; Las im&#225;genes retinianas fueron obtenidas por el mismo oftalm&#243;logo y un t&#233;cnico especializado en la captura de im&#225;genes digitales&#46; Un total de 30<span class="elsevierStyleHsp" style=""></span>sets de im&#225;genes fueron analizados por 3 grupos enmascarados&#58; grupo A &#40;8 oftalm&#243;logos&#41;&#44; grupo<span class="elsevierStyleHsp" style=""></span>B &#40;5 expertos en visi&#243;n&#41; y grupo <span class="elsevierStyleSmallCaps">C</span> &#40;2 oftalm&#243;logos expertos en ROP&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acorde con el diagn&#243;stico mediante oftalmoscopia indirecta&#44; la sensibilidad &#40;26-93&#41;&#44; el &#237;ndice Kappa &#40;0&#44;24-0&#44;80&#41; y el porcentaje de aciertos fueron estad&#237;sticamente significativos en el grupo<span class="elsevierStyleHsp" style=""></span>C para el diagn&#243;stico de ROP tipo<span class="elsevierStyleHsp" style=""></span>1&#46; En el diagn&#243;stico de ROP tipo<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>tipo<span class="elsevierStyleHsp" style=""></span>2 el &#237;ndice Kappa &#40;0&#44;17-0&#44;33&#41; y el porcentaje de aciertos &#40;58-90&#41; fueron estad&#237;sticamente significativos&#44; obteniendo valores superiores en el grupo C&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico realizado por oftalm&#243;logos expertos en ROP con el retin&#243;grafo m&#243;vil RetCam 3 ha demostrado ser un m&#233;todo fiable&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Navarro-Blanco C&#44; Peralta-Calvo J&#44; Pastora-Salvador N&#44; &#193;lvarez-Rementer&#237;a L&#44; Chamorro E&#44; S&#225;nchez-Ramos C&#46; Fiabilidad en el cribado de la retinopat&#237;a del prematuro mediante el an&#225;lisis de retinograf&#237;as&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;81&#58;149&#8211;154&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Sensitivity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Specificity &#40;&#37;&#41; &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Kappa &#40;standard error&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">CD &#40;&#37;&#41; &#40;maximum&#8211;minimum&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">93 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;24 &#40;0&#46;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">57 &#40;68&#8211;40&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Group B&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">92 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;29 &#40;0&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">56 &#40;65&#8211;47&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group C&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">86 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;33 &#40;0&#46;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Group B&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Group C&nbsp;\t\t\t\t\t\t\n
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        0 => array:2 [
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          "bibliografiaReferencia" => array:40 [
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                    0 => array:2 [
                      "titulo" => "Characteristics of infants with severe retinopathy of prematurity in countries with low&#44; moderate&#44; and high levels of development&#58; implications for screening programs"
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                        0 => array:2 [
                          "etal" => true
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                            0 => "C&#46; Gilbert"
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                            2 => "L&#46; Gordillo"
                            3 => "G&#46; Quinn"
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                            5 => "P&#46; Visintin"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2005"
                        "volumen" => "115"
                        "paginaInicial" => "518"
                        "paginaFinal" => "525"
                      ]
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                      "titulo" => "Educational paper&#58; retinopathy of prematurity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Casteels"
                            1 => "C&#46; Cassiman"
                            2 => "J&#46; van Calster"
                            3 => "K&#46; Allegaert"
                          ]
                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00431-011-1610-7"
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                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "2012"
                        "volumen" => "171"
                        "paginaInicial" => "887"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22052209"
                            "web" => "Medline"
                          ]
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                      ]
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              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A telemedicine approach to screening for retinopathy of prematurity&#58; implications for improved diagnosis and resource utilization"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neonatal Intensive Care"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "52"
                        "paginaFinal" => "54"
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              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retinopathy of prematurity&#58; do we still have a problem&#63; The Charles L&#46; Schepens lecture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Tasman"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archophthalmol.2011.192"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "2011"
                        "volumen" => "129"
                        "paginaInicial" => "1083"
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Article information
ISSN: 23412879
Original language: English
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Idiomas
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