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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Con las terapias actuales&#44; la supervivencia de los tumores del sistema nervioso central &#40;TSNC&#41; es cada vez mayor y&#44; con ello&#44; las complicaciones a largo plazo&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar las secuelas endocrinol&#243;gicas en ni&#241;os con TSNC en relaci&#243;n con el tipo de neoplasia y el tratamiento recibido&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Sujetos y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se revisaron retrospectivamente los datos cl&#237;nicos&#44; auxol&#243;gicos&#44; anal&#237;ticos y radiol&#243;gicos de 38 pacientes &#40;36&#44;8&#37; mujeres y 63&#44;2&#37; varones&#41; con antecedente de TSNC y seguimiento m&#237;nimo de 5 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La media &#177; desviaci&#243;n est&#225;ndar de edad al diagn&#243;stico fue de 5&#44;34 &#177; 3&#44;07 a&#241;os&#46; El 76&#44;3&#37; de los casos present&#243; al menos un d&#233;ficit hormonal&#44; siendo el m&#225;s prevalente el de hormona de crecimiento &#40;GH&#41; &#40;73&#44;7&#37;&#41;&#44; seguido de los d&#233;ficits de tirotropina &#40;TSH&#41; &#40;68&#44;4&#37;&#41;&#44; corticotropina &#40;31&#44;6&#37;&#41;&#44; hormona antidiur&#233;tica &#40;28&#44;9&#37;&#41; y gonadotropinas &#40;LH&#47;FSH&#41; &#40;21&#44;1&#37;&#41;&#46; El 21&#44;1&#37; de los pacientes presentaron pubertad precoz&#46; A los 5 a&#241;os de seguimiento&#44; el 28&#44;9&#37; presentaba obesidad&#46; El craneofaringioma fue el tipo tumoral que registr&#243; mayor n&#250;mero de casos con deficiencias hormonales&#44; obesidad y tasa de recurrencia&#46; El tratamiento m&#225;s frecuentemente administrado fue la combinaci&#243;n de cirug&#237;a &#43; quimioterapia &#43; radioterapia&#44; empleado en el 47&#44;4&#37; de los pacientes&#46; La talla final media &#177; desviaci&#243;n est&#225;ndar &#40;20 pacientes&#41; fue &#8722;1&#44;2 &#177; 1&#44;6&#59; con una disminuci&#243;n media de &#8722;0&#44;53 DE respecto de su talla diana&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">1&#41; El tipo tumoral y el tratamiento recibido influyen sobre las secuelas endocrinol&#243;gicas&#59; 2&#41; las deficiencias hormonales m&#225;s frecuentes en todos los tipos de TSNC&#44; independientemente del tratamiento recibido&#44; fueron GH y TSH&#59; 3&#41; el diagn&#243;stico precoz y la intervenci&#243;n temprana sobre la disfunci&#243;n endocrina&#44; reducen la morbilidad y mejoran la calidad de vida a largo plazo&#46;</p>"
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    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Previous presentation of the work&#58; certain aspects of this research were presented as a poster at the 51st Annual Meeting of the European Society of Paediatric Endocrinology &#40;ESPE&#41;&#44; held in Leipzig &#40;Germany&#41; held 20-23 September 2012&#46; The authors and title of this communication were&#58; G&#252;emes M&#44; Fuente L&#44; Caballero FJ&#44; Martos-Moreno G&#44; Mu&#241;oz-Calvo MT&#44; Argente J&#46; Endocrinological effects in survivors of central nervous system tumours after a 5 year follow-up&#8221;&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; G&#252;emes Hidalgo M&#44; Mu&#241;oz Calvo MT&#44; Fuente Blanco L&#44; Villalba Casta&#241;o C&#46; Martos Moreno GA&#44; Argente J&#46; Secuelas endocrinol&#243;gicas en ni&#241;os y adolescentes supervivientes de tumores del sistema nervioso central tras 5 a&#241;os de seguimiento&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;80&#58;357-364&#46;</p>"
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    ]
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Original Article
Endocrinological outcome in children and adolescents survivors of central nervous system tumours after a 5 year follow-up
Secuelas endocrinológicas en niños y adolescentes supervivientes de tumores del sistema nervioso central tras 5 años de seguimiento
M. Güemes Hidalgoa, M.T. Muñoz Calvoa,b,c,d,
Corresponding author
maitemunozcalvo@gmail.com

Corresponding author.
, L. Fuente Blancoa, C. Villalba Castañoa, G.A. Martos Morenoa,b,c,d, J. Argentea,b,c,d,
Corresponding author
jesus.argente@uam.es

Corresponding author.
a Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
b Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
c Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, Spain
d Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
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            "entidad" => "Centro de Investigaci&#243;n Biom&#233;dica en Red de Fisiopatolog&#237;a de la Obesidad y Nutrici&#243;n &#40;CIBERobn&#41;&#44; Instituto de Salud Carlos III&#44; Madrid&#44; Spain"
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      "es" => array:1 [
        "titulo" => "Secuelas endocrinol&#243;gicas en ni&#241;os y adolescentes supervivientes de tumores del sistema nervioso central tras 5 a&#241;os de seguimiento"
      ]
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    "fechaRecibido" => "2013-06-25"
    "fechaAceptado" => "2013-06-26"
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          "clase" => "keyword"
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            0 => "Childhood brain tumours"
            1 => "Endocrine late effects"
            2 => "Hypothalamic pituitary axis"
            3 => "Cancer survivors"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:4 [
            0 => "Tumores cerebrales infantiles"
            1 => "Secuelas endocrinas"
            2 => "Eje hipot&#225;lamo-hipofisario"
            3 => "Supervivientes de c&#225;ncer"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Given the successful increase in survival rates with the current treatments for central nervous system tumours &#40;CNST&#41;&#44; survivors are at high risk for late adverse effects&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Purpose</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the endocrine sequelae in children with CNST according to the type of tumour and treatment received&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective review of the clinical features&#44; auxology&#44; hormone determinations and imaging findings of 38 patients &#40;36&#46;8&#37; females&#44; 63&#46;2&#37; males&#41; with CNST&#44; with a minimum of 5 years follow-up&#44; was performed&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The mean age at diagnosis was 5&#46;34&#177;3&#46;07 years&#44; with 76&#46;3&#37; of the patients having at least one hormone deficiency&#44; of which growth hormone &#40;GH&#41; &#40;73&#46;7&#37; of all patients&#41; was the most prevalent&#44; followed by thyrotropin &#40;TSH&#41; &#40;68&#46;4&#37;&#41;&#44; corticotropin &#40;31&#46;6&#37;&#41;&#44; antidiuretic hormone &#40;28&#46;9&#37;&#41;&#44; and gonadotropin &#40;LH&#47;FSH&#41; &#40;21&#46;1&#37;&#41; deficiency&#46; Precocious puberty was found in 21&#46;1&#37; of patients&#46; After 5 years of follow-up&#44; 28&#46;9&#37; were obese&#46; Craniopharyngioma had more hormone deficiency&#44; obesity and recurrence rates&#46; The most frequently administered treatment was surgery &#43; chemotherapy &#43; radiotherapy&#44; in 47&#46;4&#37; of the patients&#46; Mean fi height &#40;20 patients&#41; was -1&#46;2 1&#46;6 SDS&#44; with a mean difference of -0&#46;53 SDS regarding their target height&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">1&#41; The type of tumour and treatment received influence the endocrinological sequelae&#46; 2&#41; The most frequent hormone deficiencies in all types of CNST&#44; regardless of the treatment received&#44; were GH and TSH&#46; 3&#41; Early diagnosis and prompt intervention of endocrine dysfunction can reduce the morbidity and improve quality of life over the long term&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Con las terapias actuales&#44; la supervivencia de los tumores del sistema nervioso central &#40;TSNC&#41; es cada vez mayor y&#44; con ello&#44; las complicaciones a largo plazo&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar las secuelas endocrinol&#243;gicas en ni&#241;os con TSNC en relaci&#243;n con el tipo de neoplasia y el tratamiento recibido&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Sujetos y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se revisaron retrospectivamente los datos cl&#237;nicos&#44; auxol&#243;gicos&#44; anal&#237;ticos y radiol&#243;gicos de 38 pacientes &#40;36&#44;8&#37; mujeres y 63&#44;2&#37; varones&#41; con antecedente de TSNC y seguimiento m&#237;nimo de 5 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La media &#177; desviaci&#243;n est&#225;ndar de edad al diagn&#243;stico fue de 5&#44;34 &#177; 3&#44;07 a&#241;os&#46; El 76&#44;3&#37; de los casos present&#243; al menos un d&#233;ficit hormonal&#44; siendo el m&#225;s prevalente el de hormona de crecimiento &#40;GH&#41; &#40;73&#44;7&#37;&#41;&#44; seguido de los d&#233;ficits de tirotropina &#40;TSH&#41; &#40;68&#44;4&#37;&#41;&#44; corticotropina &#40;31&#44;6&#37;&#41;&#44; hormona antidiur&#233;tica &#40;28&#44;9&#37;&#41; y gonadotropinas &#40;LH&#47;FSH&#41; &#40;21&#44;1&#37;&#41;&#46; El 21&#44;1&#37; de los pacientes presentaron pubertad precoz&#46; A los 5 a&#241;os de seguimiento&#44; el 28&#44;9&#37; presentaba obesidad&#46; El craneofaringioma fue el tipo tumoral que registr&#243; mayor n&#250;mero de casos con deficiencias hormonales&#44; obesidad y tasa de recurrencia&#46; El tratamiento m&#225;s frecuentemente administrado fue la combinaci&#243;n de cirug&#237;a &#43; quimioterapia &#43; radioterapia&#44; empleado en el 47&#44;4&#37; de los pacientes&#46; La talla final media &#177; desviaci&#243;n est&#225;ndar &#40;20 pacientes&#41; fue &#8722;1&#44;2 &#177; 1&#44;6&#59; con una disminuci&#243;n media de &#8722;0&#44;53 DE respecto de su talla diana&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">1&#41; El tipo tumoral y el tratamiento recibido influyen sobre las secuelas endocrinol&#243;gicas&#59; 2&#41; las deficiencias hormonales m&#225;s frecuentes en todos los tipos de TSNC&#44; independientemente del tratamiento recibido&#44; fueron GH y TSH&#59; 3&#41; el diagn&#243;stico precoz y la intervenci&#243;n temprana sobre la disfunci&#243;n endocrina&#44; reducen la morbilidad y mejoran la calidad de vida a largo plazo&#46;</p>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Previous presentation of the work&#58; certain aspects of this research were presented as a poster at the 51st Annual Meeting of the European Society of Paediatric Endocrinology &#40;ESPE&#41;&#44; held in Leipzig &#40;Germany&#41; held 20-23 September 2012&#46; The authors and title of this communication were&#58; G&#252;emes M&#44; Fuente L&#44; Caballero FJ&#44; Martos-Moreno G&#44; Mu&#241;oz-Calvo MT&#44; Argente J&#46; Endocrinological effects in survivors of central nervous system tumours after a 5 year follow-up&#8221;&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; G&#252;emes Hidalgo M&#44; Mu&#241;oz Calvo MT&#44; Fuente Blanco L&#44; Villalba Casta&#241;o C&#46; Martos Moreno GA&#44; Argente J&#46; Secuelas endocrinol&#243;gicas en ni&#241;os y adolescentes supervivientes de tumores del sistema nervioso central tras 5 a&#241;os de seguimiento&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;80&#58;357-364&#46;</p>"
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ISSN: 23412879
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