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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Perinatal care in extremely immature newborns is a clinical and ethical problem of great importance for professionals and families&#44; and requires that the available information on the chances of child survival is of the highest quality&#46; The aim of this study was to determine the specific rates of survival at hospital discharge&#44; and survival without major morbidity in newborns with a gestation age &#40;GA&#41; &#8804; 26 weeks in Spain&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We included live newborns &#8804; 26 weeks admitted to the collaborating centres of the SEN1500 network &#40;2004-2010&#41;&#46; Outborn patients&#44; infants who died in delivery room&#44; and those with congenital anomalies incompatible with life were excluded&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 3&#44;236 patients were included&#46; GA specific survival was 12&#46;5&#44; 13&#46;1&#44; 36&#46;9&#44; 55&#46;7&#44; and 71&#46;9&#37; at 22&#44; 23&#44; 24&#44; 25&#44; and 26 weeks of GA&#44; respectively&#46; Survival without severe intracranial haemorrhage&#44; periventricular leukomalacia&#44; bronchopulmonary dysplasia&#44; and&#47;or retinopathy of prematurity was 1&#46;5&#44; 9&#46;5&#44; 19&#46;0&#44; and 29&#46;9&#37; at 23&#44; 24&#44; 25 and 26 weeks GA&#44; respectively&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Survival without major morbidity in infants less than 23 weeks GA is exceptional&#44; and scarce in newborns with 23 and 24 weeks GA&#46; Infants &#8805; 25 weeks GA have reasonable chances of survival and&#44; in the absence of major malformations or other relevant complications&#44; they should be offered active resuscitation and intensive care&#46; The continuous updating of the results of individual centres is of utmost importance&#44; as well as their comparison with the reference population-based results&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La asistencia perinatal a reci&#233;n nacidos &#40;RN&#41; extremadamente inmaduros constituye un problema cl&#237;nico y &#233;tico de gran trascendencia para profesionales y familias&#44; y hace necesaria una informaci&#243;n actualizada de la m&#225;xima calidad acerca de las posibilidades de supervivencia del ni&#241;o&#46; El objetivo de este estudio fue conocer las tasas espec&#237;ficas de supervivencia al alta hospitalaria y de supervivencia sin morbilidad mayor conocida en RN con una edad gestacional &#40;EG&#41; &#8804; 26 semanas en Espa&#241;a&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron los RN vivos de &#8804; 26 semanas que ingresaron en los centros colaboradores de la red SEN1500 &#40;2004-2010&#41;&#46; Se excluyeron los nacidos extramuros&#44; los fallecidos en el paritorio y los que ten&#237;an malformaciones incompatibles con la vida&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En total 3&#46;236 pacientes fueron incluidos&#46; La supervivencia espec&#237;fica por EG fue de 12&#44;5&#44; 13&#44;1&#44; 36&#44;9&#44; 55&#44;7 y 71&#44;9&#37; a las 22&#44; 23&#44; 24&#44; 25 y 26 semanas de EG&#44; respectivamente&#46; La supervivencia sin hemorragia intracraneal grave&#44; leucomalacia periventricular&#44; displasia broncopulmonar y&#47;o retinopat&#237;a de la prematuridad fue del 1&#44;5&#44; 9&#44;5&#44; 19&#44;0 y 29&#44;9&#37; a las 23&#44; 24&#44; 25 y 26 semanas&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La supervivencia sin morbilidad mayor en menores de 23 semanas de EG es excepcional&#44; y en RN de 23 y 24 semanas&#44; muy baja&#46; Los RN &#8805; 25 semanas de EG tienen posibilidades razonables de supervivencia y&#44; en ausencia de malformaciones mayores u otras complicaciones relevantes&#44; se les deber&#237;a ofrecer reanimaci&#243;n activa y cuidados intensivos&#46; Es fundamental la actualizaci&#243;n continua de los datos propios de cada centro y su comparaci&#243;n con los resultados poblacionales de referencia&#46;</p>"
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ORIGINAL ARTICLE
Morbidity and mortality in newborns at the limit of viability in Spain: A population-based study
Morbimortalidad en recién nacidos al límite de la viabilidad en España: estudio de base poblacional
F. García-Muñoz Rodrigoa,
Corresponding author
fgarciamu@gmail.com

Corresponding author.
, A. García-Alix Pérezb, J.A. García Hernándezc, J. Figueras Aloyd, Grupo Sen1500
a Servicio de Neonatología, Complejo Hospitalario Universitario Insular Materno-Infantil de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
b Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
c Servicio de Ginecología y Obstetricia, Complejo Hospitalario Universitario Insular Materno-Infantil de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
d Hospital Clínic, Barcelona, Spain
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      "es" => array:1 [
        "titulo" => "Morbimortalidad en reci&#233;n nacidos al l&#237;mite de la viabilidad en Espa&#241;a&#58; estudio de base poblacional"
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          "clase" => "keyword"
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            0 => "Limits of viability"
            1 => "Extreme prematurity"
            2 => "Morbidity"
            3 => "Mortality"
            4 => "Major brain damage"
            5 => "Clinical decision- making"
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            0 => "L&#237;mites de viabilidad"
            1 => "Prematuridad extrema"
            2 => "Morbilidad"
            3 => "Mortalidad"
            4 => "Lesi&#243;n cerebral mayor"
            5 => "Toma de decisiones cl&#237;nicas"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Perinatal care in extremely immature newborns is a clinical and ethical problem of great importance for professionals and families&#44; and requires that the available information on the chances of child survival is of the highest quality&#46; The aim of this study was to determine the specific rates of survival at hospital discharge&#44; and survival without major morbidity in newborns with a gestation age &#40;GA&#41; &#8804; 26 weeks in Spain&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We included live newborns &#8804; 26 weeks admitted to the collaborating centres of the SEN1500 network &#40;2004-2010&#41;&#46; Outborn patients&#44; infants who died in delivery room&#44; and those with congenital anomalies incompatible with life were excluded&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 3&#44;236 patients were included&#46; GA specific survival was 12&#46;5&#44; 13&#46;1&#44; 36&#46;9&#44; 55&#46;7&#44; and 71&#46;9&#37; at 22&#44; 23&#44; 24&#44; 25&#44; and 26 weeks of GA&#44; respectively&#46; Survival without severe intracranial haemorrhage&#44; periventricular leukomalacia&#44; bronchopulmonary dysplasia&#44; and&#47;or retinopathy of prematurity was 1&#46;5&#44; 9&#46;5&#44; 19&#46;0&#44; and 29&#46;9&#37; at 23&#44; 24&#44; 25 and 26 weeks GA&#44; respectively&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Survival without major morbidity in infants less than 23 weeks GA is exceptional&#44; and scarce in newborns with 23 and 24 weeks GA&#46; Infants &#8805; 25 weeks GA have reasonable chances of survival and&#44; in the absence of major malformations or other relevant complications&#44; they should be offered active resuscitation and intensive care&#46; The continuous updating of the results of individual centres is of utmost importance&#44; as well as their comparison with the reference population-based results&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La asistencia perinatal a reci&#233;n nacidos &#40;RN&#41; extremadamente inmaduros constituye un problema cl&#237;nico y &#233;tico de gran trascendencia para profesionales y familias&#44; y hace necesaria una informaci&#243;n actualizada de la m&#225;xima calidad acerca de las posibilidades de supervivencia del ni&#241;o&#46; El objetivo de este estudio fue conocer las tasas espec&#237;ficas de supervivencia al alta hospitalaria y de supervivencia sin morbilidad mayor conocida en RN con una edad gestacional &#40;EG&#41; &#8804; 26 semanas en Espa&#241;a&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron los RN vivos de &#8804; 26 semanas que ingresaron en los centros colaboradores de la red SEN1500 &#40;2004-2010&#41;&#46; Se excluyeron los nacidos extramuros&#44; los fallecidos en el paritorio y los que ten&#237;an malformaciones incompatibles con la vida&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En total 3&#46;236 pacientes fueron incluidos&#46; La supervivencia espec&#237;fica por EG fue de 12&#44;5&#44; 13&#44;1&#44; 36&#44;9&#44; 55&#44;7 y 71&#44;9&#37; a las 22&#44; 23&#44; 24&#44; 25 y 26 semanas de EG&#44; respectivamente&#46; La supervivencia sin hemorragia intracraneal grave&#44; leucomalacia periventricular&#44; displasia broncopulmonar y&#47;o retinopat&#237;a de la prematuridad fue del 1&#44;5&#44; 9&#44;5&#44; 19&#44;0 y 29&#44;9&#37; a las 23&#44; 24&#44; 25 y 26 semanas&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La supervivencia sin morbilidad mayor en menores de 23 semanas de EG es excepcional&#44; y en RN de 23 y 24 semanas&#44; muy baja&#46; Los RN &#8805; 25 semanas de EG tienen posibilidades razonables de supervivencia y&#44; en ausencia de malformaciones mayores u otras complicaciones relevantes&#44; se les deber&#237;a ofrecer reanimaci&#243;n activa y cuidados intensivos&#46; Es fundamental la actualizaci&#243;n continua de los datos propios de cada centro y su comparaci&#243;n con los resultados poblacionales de referencia&#46;</p>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Garc&#237;a-Mu&#241;oz Rodrigo F&#44; Garc&#237;a-Alix P&#233;rez A&#44; Garc&#237;a Hern&#225;ndez JA&#44; Figueras Aloy J&#44; Grupo SEN1500&#46; Morbimortalidad en reci&#233;n nacidos al l&#237;mite de la viabilidad en Espa&#241;a&#58; estudio de base poblacional&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;80&#58;348-356&#46;</p>"
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