Notas Clínicas
Síndrome hemolítico urémico incompleto asociado a déficit parcial de factor H
Incomplete hemolytic uremic syndrome associated with partial factor H deficiency
Read
11032
Timeswas read the article
2993
Total PDF
8039
Total HTML
Share statistics
array:23 [ "pii" => "S1695403307703302" "issn" => "16954033" "doi" => "10.1157/13098939" "estado" => "S300" "fechaPublicacion" => "2007-02-01" "aid" => "70330" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2007;66:188-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6491 "formatos" => array:3 [ "EPUB" => 90 "HTML" => 5511 "PDF" => 890 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403307703314" "issn" => "16954033" "doi" => "10.1016/S1695-4033(07)70331-4" "estado" => "S300" "fechaPublicacion" => "2007-02-01" "aid" => "70331" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "An Pediatr (Barc). 2007;66:191-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7877 "formatos" => array:3 [ "EPUB" => 76 "HTML" => 6995 "PDF" => 806 ] ] "es" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas al Editor</span>" "titulo" => "Vacuna pentavalente frente a rotavirus: Rotateq<span class="elsevierStyleSup">®</span>" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "191" "paginaFinal" => "192" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Cisterna Viladrich" "autores" => array:1 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Cisterna Viladrich" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403307703314?idApp=UINPBA00005H" "url" => "/16954033/0000006600000002/v2_201308271339/S1695403307703314/v2_201308271339/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403307703296" "issn" => "16954033" "doi" => "10.1157/13098938" "estado" => "S300" "fechaPublicacion" => "2007-02-01" "aid" => "70329" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2007;66:184-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5701 "formatos" => array:3 [ "EPUB" => 74 "HTML" => 5106 "PDF" => 521 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Notas Clínicas</span>" "titulo" => "Eficacia de la reducción de peso en la curación de la esteatohepatitis no alcohólica en un adolescente obeso" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "184" "paginaFinal" => "187" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effectiveness of weight loss in the treatment of non-alcoholic steatohepatitis in an obese adolescent" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Cavanilles Walker, A. Solar Boga, L. García Alonso, M.J. Lorenzo Patiño" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Cavanilles Walker" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Solar Boga" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "García Alonso" ] 3 => array:2 [ "nombre" => "M.J." "apellidos" => "Lorenzo Patiño" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403307703296?idApp=UINPBA00005H" "url" => "/16954033/0000006600000002/v2_201308271339/S1695403307703296/v2_201308271339/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Notas Clínicas</span>" "titulo" => "Síndrome hemolítico urémico incompleto asociado a déficit parcial de factor H" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "188" "paginaFinal" => "190" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Olaciregui Echenique, R. Areses Trapote, M. Ubetagoyena Arrieta, I. Sota Busselo, C. García Pardos, P. Echaniz Aizpuru" "autores" => array:6 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Olaciregui Echenique" "email" => array:1 [ 0 => "iolaciregui@chdo.osakidetza.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Areses Trapote" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Ubetagoyena Arrieta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Sota Busselo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "García Pardos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "P." "apellidos" => "Echaniz Aizpuru" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidades de Lactantes, Servicio de Pediatría" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidades de Nefrología Pediátrica. Servicio de Pediatría" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Unidades de Servicio de Inmunología. Hospital Donostia. San Sebastián. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. I. Olaciregui Echenique. P.° Dr. Beguiristain, s/n. 20014. San Sebastián. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Incomplete hemolytic uremic syndrome associated with partial factor H deficiency" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-02-28" "fechaAceptado" => "2006-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec246187" "palabras" => array:5 [ 0 => "Síndrome hemolítico urémico" 1 => "Síndrome hemolítico urémico incompleto" 2 => "Síndrome hemolítico urémico atípico" 3 => "Factor H" 4 => "Campylobacter jejuni" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec246188" "palabras" => array:5 [ 0 => "Hemolytic uremic syndrome" 1 => "Incomplete hemolytic uremic syndrome" 2 => "Atypical hemolytic uremic syndrome" 3 => "Factor H" 4 => "Campylobacter jejuni" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El síndrome hemolítico urémico (SHU) asocia anemia hemolítica, trombocitopenia e insuficiencia renal. La mayoría de los casos están relacionados con las toxinas (verotoxinas) producidas por <span class="elsevierStyleItalic">Escherichia coli</span> 0157:H7 y generalmente tienen un buen pronóstico renal. Existen formas atípicas, con peor pronóstico, que pueden ser secundarias, entre otras causas, a mutaciones en el gen codificador del factor H, proteína que regula la activación de la vía alternativa del complemento. Su déficit, produce una activación continua del complemento, dañando las células endoteliales de los capilares.</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso clínico de SHU incompleto (ausencia de plaquetopenia y uremia) y atípico en el que se detectó una hipocomplementemia secundaria a un déficit parcial de factor H, cuya evolución fue favorable. Previo al inicio de los síntomas, el paciente presentó una infección por <span class="elsevierStyleItalic">Campylobacter</span> que actuó como agente precipitante del cuadro. El análisis genético demostró una mutación en heterocigosis (C846T) localizada en el dominio SCR4 que genera un cambio de aminoácido en la molécula del factor H (Pro240Leu). Es posible que dicha mutación haya sido la causante del déficit parcial del factor H y del cuadro que presentó al ingreso.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Hemolytic uremic syndrome (HUS) consists of the association of hemolytic anemia, thrombocytopenia and renal failure. Most cases are related to toxins (verotoxins) produced by <span class="elsevierStyleItalic">Escherichia coli</span> 0157:H7 and generally have good renal prognosis. Atypical forms can occur, with a less favorable prognosis, and can be due to mutations in the gene codifying factor H, a protein that regulates activation of the alternative complement pathway, among other causes. Factor H deficiency produces continuous complement activation, causing injury to capillary endothelial cells.</p><p class="elsevierStyleSimplePara elsevierViewall">We report a case of incomplete (absence of thrombocytopenia and uremia), atypical HUS in which hypocomplementemia secondary to partial factor H deficiency was detected, with favorable outcome. Prior to symptom onset, the patient had a <span class="elsevierStyleItalic">Campylobacter</span> infection, precipitating the symptoms. Genetic analysis showed a heterozygous mutation (C846T) located in the SCR4 domain, generating an amino acid change in the factor H molecule (Pro240Leu). This mutation may have been the cause of the partial factor H deficiency and the patient's symptoms on admission.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemolytic uremic syndrome; pathogenesis, treatment, and outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Siegler" 1 => "R. Oakes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pediatr." "fecha" => "2005" "volumen" => "17" "paginaInicial" => "200" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15800412" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.E. Ray" 1 => "X.H. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Nephrol." "fecha" => "2001" "volumen" => "16" "paginaInicial" => "823" "paginaFinal" => "839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11605791" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemolytic-uremic syndrome after verotoxin-producing <span class="elsevierStyleItalic">Escherichia coli</span> infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Mariani-Kurkdjian" 1 => "E. Bingen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Presse Med." "fecha" => "1995" "volumen" => "24" "paginaInicial" => "99" "paginaFinal" => "101" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7899353" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Challenges in the management of infantile factor H associated hemolytic uremic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Filler" 1 => "S. Radhakrishnan" 2 => "L. Strain" 3 => "A. Hill" 4 => "G. Knoll" 5 => "T.H. Goodship" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00467-004-1526-9" "Revista" => array:6 [ "tituloSerie" => "Pediatr Nephrol." "fecha" => "2004" "volumen" => "19" "paginaInicial" => "908" "paginaFinal" => "911" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15206027" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Licht" 1 => "A. Weyersberg" 2 => "S. Heinen" 3 => "L. Stapenhorst" 4 => "J. Devenge" 5 => "B. Beck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis." "fecha" => "2005" "volumen" => "45" "paginaInicial" => "415" "paginaFinal" => "421" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15685522" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Sánchez-Corral" 1 => "D. Pérez-Caballero" 2 => "O. Huarte" 3 => "A.M. Simckes" 4 => "E. Goicoechea" 5 => "M. López-Trascasa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/344515" "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet." "fecha" => "2002" "volumen" => "71" "paginaInicial" => "1285" "paginaFinal" => "1295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12424708" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human complement factor H: functional roles, genetic variations and disease associations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Rodríguez de Córdoba" 1 => "J. Esparza-Gordillo" 2 => "E. Goicoechea de Jorge" 3 => "M. López-Trascasa" 4 => "P. Sánchez-Corral" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.molimm.2004.02.005" "Revista" => array:6 [ "tituloSerie" => "Mol Immunol." "fecha" => "2004" "volumen" => "41" "paginaInicial" => "355" "paginaFinal" => "367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15163532" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Haemolytic uraemic syndrome and mutations of the factor H gene: A registry-based study of German speaking countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.P.H. Neumann" 1 => "M. Salzmann" 2 => "B. Bohnert-Iwan" 3 => "T. Mannuelian" 4 => "C. Skerka" 5 => "D. Lenk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Med Genet." "fecha" => "2003" "volumen" => "40" "paginaInicial" => "676" "paginaFinal" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12960213" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.K. Sharma" 1 => "M.K. Pangburn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "10996" "paginaFinal" => "11001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8855297" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.K. Pangburn" 1 => "K.L.W. Pangburn" 2 => "V. Koistinen" 3 => "S. Meri" 4 => "A.K. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol." "fecha" => "2000" "volumen" => "164" "paginaInicial" => "4742" "paginaFinal" => "4751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10779780" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterozygous and homozygous factor H deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: Report and genetic analysis of 16 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Dragon-Durey" 1 => "V. Frémeaux-Bacchi" 2 => "C. Loirat" 3 => "J. Blouin" 4 => "P. Niaudet" 5 => "G. Deschenes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol." "fecha" => "2004" "volumen" => "15" "paginaInicial" => "787" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14978182" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial hemolytic uremic syndrome associated with complement Factor H deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Landau" 1 => "H. Shalev" 2 => "G. Levy-Finer" 3 => "A. Polonsky" 4 => "Y. Segev" 5 => "L. Katchko" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mpd.2001.112649" "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "2001" "volumen" => "138" "paginaInicial" => "412" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11241053" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000006600000002/v2_201308271339/S1695403307703302/v2_201308271339/es/main.assets" "Apartado" => array:4 [ "identificador" => "14441" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Notas clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000006600000002/v2_201308271339/S1695403307703302/v2_201308271339/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403307703302?idApp=UINPBA00005H" ]
Article information
ISSN: 16954033Original language: Spanish
DOI:10.1157/13098939
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 15 | 11 | 26 |
| 2024 October | 88 | 54 | 142 |
| 2024 September | 93 | 42 | 135 |
| 2024 August | 109 | 85 | 194 |
| 2024 July | 60 | 44 | 104 |
| 2024 June | 85 | 46 | 131 |
| 2024 May | 60 | 34 | 94 |
| 2024 April | 75 | 44 | 119 |
| 2024 March | 74 | 50 | 124 |
| 2024 February | 44 | 35 | 79 |
| 2024 January | 49 | 36 | 85 |
| 2023 December | 73 | 31 | 104 |
| 2023 November | 68 | 45 | 113 |
| 2023 October | 43 | 38 | 81 |
| 2023 September | 33 | 33 | 66 |
| 2023 August | 39 | 21 | 60 |
| 2023 July | 32 | 56 | 88 |
| 2023 June | 49 | 41 | 90 |
| 2023 May | 34 | 24 | 58 |
| 2023 April | 37 | 26 | 63 |
| 2023 March | 33 | 37 | 70 |
| 2023 February | 40 | 23 | 63 |
| 2023 January | 21 | 37 | 58 |
| 2022 December | 52 | 21 | 73 |
| 2022 November | 52 | 41 | 93 |
| 2022 October | 37 | 59 | 96 |
| 2022 September | 42 | 31 | 73 |
| 2022 August | 49 | 67 | 116 |
| 2022 July | 20 | 53 | 73 |
| 2022 June | 31 | 43 | 74 |
| 2022 May | 35 | 38 | 73 |
| 2022 April | 29 | 43 | 72 |
| 2022 March | 32 | 59 | 91 |
| 2022 February | 33 | 36 | 69 |
| 2022 January | 20 | 51 | 71 |
| 2021 December | 32 | 37 | 69 |
| 2021 November | 33 | 53 | 86 |
| 2021 October | 24 | 61 | 85 |
| 2021 September | 37 | 53 | 90 |
| 2021 August | 41 | 34 | 75 |
| 2021 July | 31 | 37 | 68 |
| 2021 June | 41 | 40 | 81 |
| 2021 May | 54 | 21 | 75 |
| 2021 April | 120 | 98 | 218 |
| 2021 March | 82 | 23 | 105 |
| 2021 February | 69 | 16 | 85 |
| 2021 January | 46 | 23 | 69 |
| 2020 December | 48 | 27 | 75 |
| 2020 November | 17 | 14 | 31 |
| 2020 October | 18 | 10 | 28 |
| 2020 September | 23 | 13 | 36 |
| 2020 August | 17 | 7 | 24 |
| 2020 July | 18 | 18 | 36 |
| 2020 June | 22 | 16 | 38 |
| 2020 May | 18 | 16 | 34 |
| 2020 April | 19 | 29 | 48 |
| 2020 March | 23 | 15 | 38 |
| 2020 February | 19 | 11 | 30 |
| 2020 January | 21 | 24 | 45 |
| 2019 December | 33 | 24 | 57 |
| 2019 November | 15 | 17 | 32 |
| 2019 October | 14 | 30 | 44 |
| 2019 September | 15 | 15 | 30 |
| 2019 August | 20 | 20 | 40 |
| 2019 July | 22 | 16 | 38 |
| 2019 June | 20 | 34 | 54 |
| 2019 May | 67 | 34 | 101 |
| 2019 April | 18 | 33 | 51 |
| 2019 March | 14 | 16 | 30 |
| 2019 February | 14 | 17 | 31 |
| 2019 January | 12 | 33 | 45 |
| 2018 December | 18 | 38 | 56 |
| 2018 November | 26 | 31 | 57 |
| 2018 October | 31 | 28 | 59 |
| 2018 September | 23 | 17 | 40 |
| 2018 July | 2 | 2 | 4 |
| 2018 June | 1 | 0 | 1 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 11 | 0 | 11 |
| 2018 March | 9 | 1 | 10 |
| 2018 February | 4 | 0 | 4 |
| 2018 January | 6 | 0 | 6 |
| 2017 December | 4 | 1 | 5 |
| 2017 November | 9 | 0 | 9 |
| 2017 October | 8 | 0 | 8 |
| 2017 September | 12 | 1 | 13 |
| 2017 August | 5 | 0 | 5 |
| 2017 July | 15 | 0 | 15 |
| 2017 June | 13 | 26 | 39 |
| 2017 May | 15 | 28 | 43 |
| 2017 April | 17 | 24 | 41 |
| 2017 March | 11 | 17 | 28 |
| 2017 February | 10 | 22 | 32 |
| 2017 January | 5 | 4 | 9 |
| 2016 December | 20 | 4 | 24 |
| 2016 November | 39 | 12 | 51 |
| 2016 October | 34 | 17 | 51 |
| 2016 September | 34 | 16 | 50 |
| 2016 August | 41 | 14 | 55 |
| 2016 July | 23 | 16 | 39 |
| 2016 June | 2 | 0 | 2 |
| 2016 May | 3 | 0 | 3 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 1 | 0 | 1 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 0 | 28 | 28 |
| 2015 September | 2 | 24 | 26 |
| 2015 August | 3 | 19 | 22 |
| 2015 July | 9 | 0 | 9 |
| 2015 June | 6 | 8 | 14 |
| 2015 May | 9 | 10 | 19 |
| 2015 April | 8 | 11 | 19 |
| 2015 March | 9 | 0 | 9 |
| 2015 February | 12 | 9 | 21 |
| 2015 January | 11 | 1 | 12 |
| 2014 December | 23 | 2 | 25 |
| 2014 November | 20 | 3 | 23 |
| 2014 October | 17 | 2 | 19 |
| 2014 September | 19 | 2 | 21 |
| 2014 August | 20 | 4 | 24 |
| 2014 July | 26 | 4 | 30 |
| 2014 June | 40 | 4 | 44 |
| 2014 May | 87 | 9 | 96 |
| 2014 April | 78 | 10 | 88 |
| 2014 March | 84 | 9 | 93 |
| 2014 February | 63 | 10 | 73 |
| 2014 January | 66 | 17 | 83 |
| 2013 December | 81 | 8 | 89 |
| 2013 November | 68 | 5 | 73 |
| 2013 October | 84 | 12 | 96 |
| 2013 September | 54 | 12 | 66 |
| 2013 August | 43 | 11 | 54 |
| 2013 July | 45 | 6 | 51 |
| 2013 June | 6 | 3 | 9 |
| 2013 May | 5 | 3 | 8 |
| 2013 April | 4 | 1 | 5 |
| 2013 March | 13 | 3 | 16 |
| 2013 February | 23 | 0 | 23 |
| 2013 January | 11 | 0 | 11 |
| 2012 December | 6 | 2 | 8 |
| 2012 November | 4 | 1 | 5 |
| 2012 October | 2 | 0 | 2 |
| 2012 September | 1 | 0 | 1 |
| 2012 August | 1 | 1 | 2 |
| 2007 February | 3692 | 0 | 3692 |
Show all
