Notas Clínicas
Eficacia de la reducción de peso en la curación de la esteatohepatitis no alcohólica en un adolescente obeso
Effectiveness of weight loss in the treatment of non-alcoholic steatohepatitis in an obese adolescent
E. Cavanilles Walkera, A. Solar Bogaa,
, L. García Alonsoa, M.J. Lorenzo Patiñob
Corresponding author
asolbog@canalejo.org
Correspondencia: Dr. A. Solar Boga. Servicio de Pediatría. Hospital Materno-Infantil. Centro Hospitalario Universitario Juan Canalejo. Jubias, 84. 15006 A Coruña. España.
Correspondencia: Dr. A. Solar Boga. Servicio de Pediatría. Hospital Materno-Infantil. Centro Hospitalario Universitario Juan Canalejo. Jubias, 84. 15006 A Coruña. España.
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"apellidos" => "Cavanilles Walker" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Solar Boga" "email" => array:1 [ 0 => "asolbog@canalejo.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "García Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "M.J." "apellidos" => "Lorenzo Patiño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicios de Pediatría, Hospital Materno-Infantil. Centro Hospitalario Universitario Juan Canalejo. A Coruña. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicios de Anatomía Patológica. Hospital Materno-Infantil. Centro Hospitalario Universitario Juan Canalejo. A Coruña. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. A. Solar Boga. Servicio de Pediatría. Hospital Materno-Infantil. Centro Hospitalario Universitario Juan Canalejo. Jubias, 84. 15006 A Coruña. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effectiveness of weight loss in the treatment of non-alcoholic steatohepatitis in an obese adolescent" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-10-31" "fechaAceptado" => "2006-07-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec246185" "palabras" => array:5 [ 0 => "Enfermedad hepática grasa no alcohólica" 1 => "Esteatohepatitis" 2 => "Obesidad" 3 => "Niños" 4 => "Dieta" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec246186" "palabras" => array:5 [ 0 => "Non-alcoholic fatty liver disease" 1 => "Steatohepatitis" 2 => "Obesity" 3 => "Children" 4 => "Diet" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La obesidad infantil es el trastorno nutricional más frecuente en los países desarrollados, habiendo sido declarada por la Organización Mundial de la Salud como una epidemia global. En los niños, al igual que ocurre en los adultos, la obesidad es el factor de riesgo más importante para el desarrollo de la enfermedad hepática grasa no alcohólica, por lo que es probable que se convierta en la enfermedad hepática crónica infantil más frecuente. Sin embargo las publicaciones pediátricas sobre este trastorno, que puede llegar a ocasionar una grave enfermedad hepática con riesgo para la vida, son relativamente poco numerosas, con series pequeñas y con escasos estudios histológicos. El artículo describe a un adolescente obeso en el que se demostró esteatosis grave y esteatohepatitis que respondieron con normalización analítica e histológica a la reducción de peso. Se alerta sobre el incremento de esta comorbilidad de la obesidad en la población pediátrica.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Childhood obesity is the most frequent nutritional disorder in developed countries and has been described as a global epidemic by the World Health Organization. In children, as in adults, obesity is the most significant risk factor for the development of non-alcoholic fatty liver disease. Therefore, it may become the most frequent chronic liver disease in children. However, pediatric publications on this disorder, which can progress to severe liver disease with risk of mortality, are scarce, with small series and few histological studies. The present article describes an obese adolescent who presented severe steatosis and steatohepatitis, which responded to weight loss with clinical and histological normalization. The risk of obesity comorbidity is increasing significantly in the pediatric population.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonalcoholic fatty liver disease in the pediatric population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Lavine" 1 => "J.B. Schwimmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cld.2004.04.010" "Revista" => array:6 [ "tituloSerie" => "Clin Liver Dis." "fecha" => "2004" "volumen" => "8" "paginaInicial" => "549" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15331063" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent hyperaminotransferasemia resolving after weight reduction in obese children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Vajro" 1 => "A. Fontanella" 2 => "C. Perna" 3 => "G. Orso" 4 => "M. Tedesco" 5 => "A. De Vicenzo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1994" "volumen" => "125" "paginaInicial" => "239" "paginaFinal" => "241" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8040771" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonalcoholic steatohepatitis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Rashid" 1 => "E.A. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr." "fecha" => "2000" "volumen" => "30" "paginaInicial" => "48" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10630439" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Charlton" 1 => "P. Kasparova" 2 => "S. Weston" 3 => "K. Lindor" 4 => "Y. Maor-Kendler" 5 => "R.H. Wiesner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jlts.2001.25453" "Revista" => array:6 [ "tituloSerie" => "Liver Transpl." "fecha" => "2001" "volumen" => "7" "paginaInicial" => "608" "paginaFinal" => "614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11460228" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Shimada" 1 => "E. Hashimoto" 2 => "M. Taniai" 3 => "K. Hasegawa" 4 => "H. Okuda" 5 => "N. Hayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol." "fecha" => "2002" "volumen" => "37" "paginaInicial" => "154" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12076877" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Policy Statement. Committee on Nutrition. Prevention of pediatric overweight and obesity" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Academy of Pediatrics" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2003" "volumen" => "112" "paginaInicial" => "424" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12897303" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonalcoholic steatohepatitis: Definition and pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.M. Brunt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Liver Dis." "fecha" => "2001" "volumen" => "21" "paginaInicial" => "3" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296695" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver pathology and the metabolic syndrome X in severe obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Marceau" 1 => "S. Biron" 2 => "F.-S. Hould" 3 => "S. Marceau" 4 => "S. Simard" 5 => "S.N. Thung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.84.5.5661" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab." "fecha" => "1999" "volumen" => "84" "paginaInicial" => "1513" "paginaFinal" => "1517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10323371" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-alcoholic steatohepatitis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N. Kerkar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Trasplantation" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "613" "paginaFinal" => "618" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamine E treatment of nonalcoholic steatohepatitis in children: A pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.E. Lavine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Pediatr." "fecha" => "2000" "volumen" => "136" "paginaInicial" => "734" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10839868" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603124889" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features and natural history of nonalcoholic steatosis syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Falck-Ytter" 1 => "Z.M. Younossi" 2 => "G. Marchesini" 3 => "J. McCullough" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sem Liver Dis." "fecha" => "2001" "volumen" => "21" "paginaInicial" => "17" "paginaFinal" => "26" "itemHostRev" => array:3 [ "pii" => "S0140673603131741" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of nonalcoholic fatty liver disease with insulin resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Marchesini" 1 => "M. Brizi" 2 => "A.M. Morselli-Labate" 3 => "G. Bianchi" 4 => "E. Bugianesi" 5 => "A.J. McCullough" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med." "fecha" => "1999" "volumen" => "107" "paginaInicial" => "450" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10569299" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NASH and insulin resistanse: Insulin hypersecretion and specific association with the insulin resistance syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Chitturi" 1 => "S. Abeygunasekera" 2 => "G.C. Farell" 3 => "J. Holmes-Walker" 4 => "J.M. Hui" 5 => "C. Fung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2002.30692" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2002" "volumen" => "35" "paginaInicial" => "373" "paginaFinal" => "379" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11826411" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver involvement in obese children Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Franzese" 1 => "P. Vajro" 2 => "A. Argenziano" 3 => "A. Puzziello" 4 => "M.P. Iannucci" 5 => "M.C. Saviano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci." "fecha" => "1997" "volumen" => "42" "paginaInicial" => "1428" "paginaFinal" => "1432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9246041" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of anormal serun aminotransferase values in overweight and obese adolescents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.S. Strauss" 1 => "S.E. Barlow" 2 => "W.H. Dietz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "2000" "volumen" => "136" "paginaInicial" => "727" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10839867" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steatohepatitis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.A. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jsat.2015.01.009" "Revista" => array:6 [ "tituloSerie" => "Best Practice & Research Clinical Gastroenterology" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "749" "paginaFinal" => "765" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25795601" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The spectrum of fatty liver in obese children and the relathionship of serum minotransferases to severity of steatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Fishbein" 1 => "M. Miner" 2 => "C. Mogren" 3 => "J. Chalekson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr." "fecha" => "2003" "volumen" => "36" "paginaInicial" => "54" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12499997" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonalcoholic steatohepatitis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.A. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Current Gastroenterology Reports" "fecha" => "2003" "volumen" => "5" "paginaInicial" => "253" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734049" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A low-glycemic index diet in the treatment of pediatric obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.E. Spieth" 1 => "J.D. Harnish" 2 => "C.M. Lenders" 3 => "L.B. Raezer" 4 => "M.A. Pereira" 5 => "S.J. Hagen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pediatr Adolesc Med." "fecha" => "2000" "volumen" => "154" "paginaInicial" => "947" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10980801" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Vajro" 1 => "A. Franzese" 2 => "G. Valerio" 3 => "M.P. Iannucci" 4 => "N. Aragione" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." 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Article information
ISSN: 16954033Original language: Spanish
DOI:10.1157/13098938
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| 2017 June | 17 | 14 | 31 |
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| 2015 December | 4 | 0 | 4 |
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| 2015 September | 2 | 0 | 2 |
| 2015 August | 2 | 9 | 11 |
| 2015 July | 18 | 0 | 18 |
| 2015 June | 16 | 0 | 16 |
| 2015 May | 11 | 3 | 14 |
| 2015 April | 12 | 0 | 12 |
| 2015 March | 12 | 0 | 12 |
| 2015 February | 13 | 3 | 16 |
| 2015 January | 23 | 0 | 23 |
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| 2013 July | 36 | 3 | 39 |
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| 2013 May | 9 | 1 | 10 |
| 2013 April | 8 | 1 | 9 |
| 2013 March | 12 | 4 | 16 |
| 2013 February | 26 | 1 | 27 |
| 2013 January | 28 | 0 | 28 |
| 2012 December | 34 | 1 | 35 |
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