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Clínica de presentación de los tumores de sistema nervioso central en función de la edad
Presenting signs and symptoms of central nervous system tumors according to age
J.F. Coserria Sánchez
, A.I. Garrido Ocaña, E. Quiroga Cantero, A.M.ª Reina González, A.P. Amadeu Da Costa, N. García Zarza
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felixcos@yahoo.es
Correspondencia: Dr. J.F. Coserria Sánchez. Alte. León Herrero, 3, esc. 2, 1.° C. 11100 San Fernando. Cádiz. España.
Correspondencia: Dr. J.F. Coserria Sánchez. Alte. León Herrero, 3, esc. 2, 1.° C. 11100 San Fernando. Cádiz. España.
Servicio de Oncología Infantil. Hospital Infantil. Hospitales Universitarios Virgen del Rocío. Sevilla. España
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"apellidos" => "Coserria Sánchez" "email" => array:1 [ 0 => "felixcos@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "A.I." "apellidos" => "Garrido Ocaña" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Quiroga Cantero" ] 3 => array:2 [ "nombre" => "A.M.ª" "apellidos" => "Reina González" ] 4 => array:2 [ "nombre" => "A.P." "apellidos" => "Amadeu Da Costa" ] 5 => array:2 [ "nombre" => "N." "apellidos" => "García Zarza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Oncología Infantil. Hospital Infantil. Hospitales Universitarios Virgen del Rocío. Sevilla. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. J.F. Coserria Sánchez. Alte. León Herrero, 3, esc. 2, 1.° C. 11100 San Fernando. Cádiz. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Presenting signs and symptoms of central nervous system tumors according to age" ] ] "presentadoPor" => "Presentado en: XV Jornadas Internacionales sobre Cáncer Infantil. Sevilla, marzo 2005." "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-05-31" "fechaAceptado" => "2006-09-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec246168" "palabras" => array:5 [ 0 => "Sistema nervioso central" 1 => "Niños" 2 => "Cefalea" 3 => "Vómitos" 4 => "Papiledema" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec246167" "palabras" => array:5 [ 0 => "Central nervous system" 1 => "Children" 2 => "Headache" 3 => "Vomiting" 4 => "Papilledema" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los tumores del sistema nervioso central suponen el segundo conjunto de neoplasias más frecuentes en niños y constituyen la primera causa de muerte relacionada con el cáncer en la edad infantil. No existen hallazgos clínicos patognomónicos, por lo que es preciso definir datos clínicos que ayuden en el diagnóstico.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Establecer los signos y síntomas de presentación de los tumores cerebrales infantiles según la edad y su influencia en la demora diagnóstica.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudian retrospectivamente 69 pacientes con tumores de sistema nervioso central diagnosticados entre enero de 1997 y diciembre de 2002 en el Hospital Infantil Virgen del Rocío.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 60,9% de los pacientes se encontraban en los estadios clínicos más avanzados en el diagnóstico. Los signos exploratorios más encontrados fueron el papiledema, la ataxia y el estrabismo, sin diferencias entre los grupos de edad. Los síntomas más hallados en el diagnóstico fueron los vómitos, cefalea y alteraciones del comportamiento (irritabilidad en los menores de 5 años, y la apariencia infeliz en los mayores de 5 años). La demora diagnóstica fue mayor en los pacientes mayores de 5 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los signos y síntomas en el diagnóstico de los tumores cerebrales infantiles son muy inespecíficos y es preciso tener en cuenta su posible existencia para un diagnóstico lo más precoz posible.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Central nervous system tumors are the second most frequent group of neoplasms in children and are the main cause of cancer-related deaths in the pediatric population. There are no specific clinical findings. Consequently clinical data that would aid diagnosis are required.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To establish the presenting signs and symptoms of brain tumors in childhood according to age and identify their influence on diagnostic delay.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We retrospectively studied 69 patients with central nervous system tumors diagnosed between January 1997 and December 2002 in the Virgen del Rocío children's hospital.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At diagnosis, 60.9% of the patients were in the most advanced clinical stages. The most commonly found signs were papilledema, ataxia and squint, with no differences among age groups. The most frequent symptoms were vomiting, headache and behavior changes (irritability in children aged less than 5 years and unhappiness in children aged more than 5 years). Diagnostic delay was longer in older children.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The diagnostic signs and symptoms of central nervous tumors are non-specific. A high index of suspicion is required for early diagnosis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic impact of children with brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.A. Bleyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s003810050467" "Revista" => array:6 [ "tituloSerie" => "Childs Nerv Syst." "fecha" => "1999" "volumen" => "15" "paginaInicial" => "758" "paginaFinal" => "763" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10603019" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in childhood cancer incidence and mortality in Catalonia, Spain, 1975-1998" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.R. González" 1 => "E. Fernández" 2 => "J.S. De Toledo" 3 => "J. Galcerán" 4 => "M. Peris" 5 => "R. Gispert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer Prev." "fecha" => "2004" "volumen" => "13" "paginaInicial" => "47" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15075788" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumors of the central nervous system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.L. Heideman" 1 => "R.J. Packer" 2 => "L.A. Albright" 3 => "C.R. Freeman" 4 => "L.B. Rorke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Principles and practice of pediatric oncology" "paginaInicial" => "633" "paginaFinal" => "697" "edicion" => "3.ª ed" "serieFecha" => "1997" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumores del sistema nervioso central en la infancia: aspectos clinicopatológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Ortega-Aznar" 1 => "F.J. Romero-Vidal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol." "fecha" => "2004" "volumen" => "38" "paginaInicial" => "554" "paginaFinal" => "564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15054721" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Social, emotional, and behavioral functioning of children with cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.B. Noll" 1 => "M.A. Gartstein" 2 => "K. Vannatta" 3 => "J. Correll" 4 => "W.M. Bukowski" 5 => "H. Davies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1999" "volumen" => "103" "paginaInicial" => "71" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9917442" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Headaches and brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Purdy" 1 => "S. Kirby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0733-8619(03)00099-9" "Revista" => array:6 [ "tituloSerie" => "Neurol Clin." "fecha" => "2004" "volumen" => "22" "paginaInicial" => "39" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15062527" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seizures as presenting symptom of brain tumors in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Ibrahim" 1 => "R. Appleton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Seizure" "fecha" => "2004" "volumen" => "13" "paginaInicial" => "108" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15129840" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vomiting as a first neurological sign of brain tumors in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.F. Bos" 1 => "C. Ramaker" 2 => "W.J. Van Ouwerkwerk" 3 => "W.H. Linssen" 4 => "B.H. Wolf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ned Tijdschr Geneeskd" "fecha" => "2002" "volumen" => "146" "paginaInicial" => "1393" "paginaFinal" => "1398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12174430" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World Health Organization Classification of Tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Kleihues" 1 => "W.K. Cavanee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2000" "editorial" => "International Agency for Research on Cancer Press" "editorialLocalizacion" => "Lyons" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J. Packer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pediatr." "fecha" => "1997" "volumen" => "9" "paginaInicial" => "551" "paginaFinal" => "557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9425586" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: A population based study of pediatric brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "U. Hjalmars" 1 => "M. Kulldorff" 2 => "Y. Wahlqvist" 3 => "B. Lannering" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1999" "volumen" => "85" "paginaInicial" => "2077" "paginaFinal" => "2090" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10223251" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Why are brain tumors still being missed?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Edgeworth" 1 => "P. Bullock" 2 => "A. Bailey" 3 => "A. Gallagher" 4 => "M. Crouchman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "1996" "volumen" => "74" "paginaInicial" => "148" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8660079" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial tumors during the first two years of life: Presenting features" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.S. Gordon" 1 => "S.J. Wallace" 2 => "J.W. Neal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "1995" "volumen" => "73" "paginaInicial" => "345" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7492201" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Latency between symptom onset and diagnosis of pediatric brain tumors: An eastern canadian geographic study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Mehta" 1 => "A. Chapman" 2 => "P.D. McNeely" 3 => "S. Walling" 4 => "W.J. Howes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "365" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12182774" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Children with brain tumor headaches" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.J. Honig" 1 => "E.B. Charney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dis Child" "fecha" => "1982" "volumen" => "136" "paginaInicial" => "121" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7064925" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain tumors in childhood and adolescence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.L. Keene" 1 => "E. Hsu" 2 => "E. Ventureyra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Neurol." "fecha" => "1999" "volumen" => "20" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10207928" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delay in the diagnosis of paediatric brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.E. Flores" 1 => "D.L. Williams" 2 => "B.A. Bell" 3 => "M. O’Brien" 4 => "A. Ragab" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dis Child" "fecha" => "1986" "volumen" => "140" "paginaInicial" => "684" "paginaFinal" => "686" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3012997" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interval between symptoms opset and diagnosis of paediatric brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.H. Pollock" 1 => "J.P. Krischer" 2 => "T.J. Vietti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1991" "volumen" => "119" "paginaInicial" => "725" "paginaFinal" => "732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1941378" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinants of symptom interval in childhood cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Saha" 1 => "S. Love" 2 => "T. Eden" 3 => "P. Micallef-Eynaud" 4 => "G. 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Article information
ISSN: 16954033Original language: Spanish
DOI:10.1157/13098927
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| 2017 July | 13 | 1 | 14 |
| 2017 June | 20 | 22 | 42 |
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| 2016 April | 1 | 0 | 1 |
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| 2015 December | 2 | 0 | 2 |
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| 2015 October | 7 | 22 | 29 |
| 2015 September | 2 | 19 | 21 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 9 | 0 | 9 |
| 2015 June | 13 | 4 | 17 |
| 2015 May | 14 | 0 | 14 |
| 2015 April | 12 | 16 | 28 |
| 2015 March | 15 | 0 | 15 |
| 2015 February | 14 | 14 | 28 |
| 2015 January | 21 | 1 | 22 |
| 2014 December | 32 | 1 | 33 |
| 2014 November | 19 | 1 | 20 |
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| 2013 August | 53 | 23 | 76 |
| 2013 July | 67 | 5 | 72 |
| 2013 June | 7 | 2 | 9 |
| 2013 May | 7 | 4 | 11 |
| 2013 April | 7 | 0 | 7 |
| 2013 March | 10 | 3 | 13 |
| 2013 February | 31 | 3 | 34 |
| 2013 January | 26 | 0 | 26 |
| 2012 December | 15 | 0 | 15 |
| 2012 November | 8 | 0 | 8 |
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