Originales
Factores de riesgo y prevalencia familiar de la dermatitis atópica en España (estudio ELIHO)
Risk factors for atopic dermatitis and familial prevalence in spain (eliho study)
A. Blanco Quirósa,
, J.M.ª Díaz Castellab, M. Balañá Vilanovac, N. Valveny Llobetd
Corresponding author
ablanco@ped.uva.es
Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España.
Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España.
Read
11106
Timeswas read the article
3915
Total PDF
7191
Total HTML
Share statistics
array:23 [ "pii" => "S1695403305702460" "issn" => "16954033" "doi" => "10.1016/S1695-4033(05)70246-0" "estado" => "S300" "fechaPublicacion" => "2005-12-01" "aid" => "70246" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2005" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2005;63:480-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6155 "formatos" => array:3 [ "EPUB" => 77 "HTML" => 4958 "PDF" => 1120 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403305702472" "issn" => "16954033" "doi" => "10.1016/S1695-4033(05)70247-2" "estado" => "S300" "fechaPublicacion" => "2005-12-01" "aid" => "70247" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2005;63:489-94" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 8059 "formatos" => array:3 [ "EPUB" => 80 "HTML" => 6902 "PDF" => 1077 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Infección por <span class="elsevierStyleItalic">Helicobacter pylori</span> en población infantil: prevalencia, factores asociados e influencia sobre el crecimiento" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "489" "paginaFinal" => "494" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> infection in the child population in spain: prevalence, related factors and influence on growth" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S.V. Leandro Liberato, M. Hernández Galindo, L. Torroba Álvarez, F. Sánchez Miramón, S.E. Leandro Ciriza, A. Gómez Abadía, P. Chueca Rodríguez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S.V." "apellidos" => "Leandro Liberato" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Hernández Galindo" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Torroba Álvarez" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Sánchez Miramón" ] 4 => array:2 [ "nombre" => "S.E." "apellidos" => "Leandro Ciriza" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Gómez Abadía" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Chueca Rodríguez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403305702472?idApp=UINPBA00005H" "url" => "/16954033/0000006300000006/v1_201307051457/S1695403305702472/v1_201307051457/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403305702459" "issn" => "16954033" "doi" => "10.1016/S1695-4033(05)70245-9" "estado" => "S300" "fechaPublicacion" => "2005-12-01" "aid" => "70245" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2005;63:475-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6092 "formatos" => array:3 [ "EPUB" => 83 "HTML" => 5229 "PDF" => 780 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Estudio de la morfología y la función renal en niños diagnosticados de enuresis nocturna. Su relación con la sensibilidad o la resistencia a la desmopresina" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "475" "paginaFinal" => "479" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Study of renal morphology and function in children with nocturnal enuresis. Relationship with sensitivity or resistance to desmopressin" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C.L. Marrero Pérez, V. García Nieto, M.I. Luis Yanes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C.L." "apellidos" => "Marrero Pérez" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "García Nieto" ] 2 => array:2 [ "nombre" => "M.I." "apellidos" => "Luis Yanes" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403305702459?idApp=UINPBA00005H" "url" => "/16954033/0000006300000006/v1_201307051457/S1695403305702459/v1_201307051457/es/main.assets" ] "es" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Factores de riesgo y prevalencia familiar de la dermatitis atópica en España (estudio ELIHO)" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "480" "paginaFinal" => "488" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Blanco Quirós, J.M.ª Díaz Castella, M. Balañá Vilanova, N. Valveny Llobet" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Blanco Quirós" "email" => array:1 [ 0 => "ablanco@ped.uva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J.M.ª" "apellidos" => "Díaz Castella" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Balañá Vilanova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "N." "apellidos" => "Valveny Llobet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Facultad de Medicina. Universidad de Valladolid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Novartis Farmacéutica, S.A.Departamento I + D. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "CDC Spain. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Infociencia S.L. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk factors for atopic dermatitis and familial prevalence in spain (eliho study)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-08-31" "fechaAceptado" => "2005-08-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186260" "palabras" => array:8 [ 0 => "Dermatitis atópica" 1 => "Eccema" 2 => "Epidemiología" 3 => "Hipersensibilidad" 4 => "Genética" 5 => "Clima" 6 => "Acné" 7 => "Factores de riesgo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186259" "palabras" => array:7 [ 0 => "Atopic dermatitis" 1 => "Eczema" 2 => "Epidemiology" 3 => "Hypersensitivity.Genetics" 4 => "Climate" 5 => "Acne vulgaris" 6 => "Risk factors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis atópica (DA) es una enfermedad de etiología desconocida, con clara predisposición genética y una probable participación de factores ambientales. El objetivo del estudio era evaluar los factores de riesgo asociados al diagnóstico y aparición de brotes de DA en niños españoles.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, multicéntrico, retrospectivo de casos y control que incluyó una muestra de 4.243 niños menores de 14 años afectados de DA y 978 controles ajustados por edad y sexo. Se recogieron datos de antecedents familiares y características del entorno familiar en ambos grupos y características clínicas de la DA en los pacientes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los factores de riesgo significativos para la aparición de DA fueron los antecedentes familiares y las infecciones concomitantes de la piel. La prevalencia de DA en familiars de primer grado fue del 39 % y en familiares de Segundo grado, del 19 % (superior en línea materna que paterna).a edad media de los niños afectados fue de 4,2 (desviación estándar [DE] 3,4) años y la edad media en el diagnóstico fue de 1,5 (DE 2,2) años, con un número medio de brotes de la enfermedad de 2,9 (DE 2,6) en el año previo. En las zonas de España con clima más frío (cantábrico y continental) se observó mayor número de brotes.Los niños con DA presentaron mayor coincidencia de enfermedades cutáneas e infecciosas que los niños control.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La DA es una enfermedad con una gran predisposición genética, modulada por factores climáticos y que acarrea alteraciones inmunológicas. Por el contrario no encontramos influencias significativas de factores ambientales domésticos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Atopic dermatitis (AD) is a cutaneous disease of unknown etiology. It shows a clear genetic predisposition with probable environmental modulation. This study evaluated risk factors associated with diagnosis and flares of AD in Spanish children.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed an observational, multicenter, retrospective case-control study that included 4243 children aged less than 14 years old with AD and 978 controls matched for age and sex. Family history of disease and environmental variables were collected in both groups and clinical history of AD was recorded in the case group.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Significant risk factors for AD were: a family history of the disease and concomitant cutaneous infections. The prevalence of AD in first degree relatives was 39 % and that in second degree relatives was 19 % (higher in maternal than paternal lines). The mean age of children with AD was 4.2 (SD 3.4) years and the mean age at diagnosis was 1.5 (SD 2.2) years, with a mean of 2.9 (SD 2.6) flares during the previous year. Cold weather (Cantabrian and Continental Iberian Peninsula areas) was related to a greater number of flares. Children with AD had a greater number of concomitant cutaneous diseases and infections than children in the control group.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">AD is mainly a genetic disease, with climatic factors involved in severity modulation, and with important immunological alterations. In contrast, this study found no domestic environmental factors that were associated with disease onset.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Declaración de conflicto de intereses: Este trabajo ha sido realizado con el apoyo económico de Novartis Farmacéutica, S.A.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural history and clinical manifestations of atopic eczema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Rajka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Clin Rev Allergy" "fecha" => "1986" "volumen" => "4" "paginaInicial" => "326" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of dermatologic disease in the United States: a review of the National Health and Nutrition Examination Survey, 1971-1974" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.L. Johnson" 1 => "J. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Ind Med" "fecha" => "1985" "volumen" => "8" "paginaInicial" => "451" "paginaFinal" => "460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4073044" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis atópica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Zambrano" 1 => "E. Zambrano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Tratado de Pediatría Extrahospitalaria" "fecha" => "2001" "paginaInicial" => "764" "paginaFinal" => "769" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis atópica en la edad infantil. Valoración de la gravedad y tratamiento" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Muñoz López" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Jano" "fecha" => "2002" "volumen" => "62" "paginaInicial" => "52" "paginaFinal" => "57" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis atópica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "I. Bielsa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "FMC" "fecha" => "2002" "volumen" => "9" "paginaInicial" => "719" "paginaFinal" => "729" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.S. Larsen" 1 => "J.M. Hanifin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Immunol Allergy Clinics" "fecha" => "2002" "volumen" => "22" "paginaInicial" => "1" "paginaFinal" => "25" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "351" "paginaInicial" => "1225" "paginaFinal" => "1232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9643741" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment principles of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Thestrup-Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JEADV" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "1" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12428630" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comité de la SAP" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Consenso Nacional de Dermatitis Atópica en la Infancia" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Argent Pediatr" "fecha" => "1999" "volumen" => "97" "paginaInicial" => "285" "paginaFinal" => "288" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Bradley" 1 => "C. Soderhall" 2 => "H. Luthman" 3 => "C.F. Wahlgren" 4 => "I. Kockum" 5 => "M. Nordenskjold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Mol Genet" "fecha" => "2002" "volumen" => "11" "paginaInicial" => "1539" "paginaFinal" => "1548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12045207" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of association and linkage for the interleukin-4 and interleukin-4 receptor b; alpha; regions in Swedish atopic dermatitis families" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Soderhall" 1 => "M. Bradley" 2 => "I. Kockum" 3 => "H. Luthman" 4 => "C.F. Wahlgren" 5 => "M. Nordenskjold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2002" "volumen" => "32" "paginaInicial" => "1199" "paginaFinal" => "1202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12190659" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic epidemiology of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.F. Schultz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Atopic Dermatitis: The epidemiology, Causes and Prevention of Atopic Eczema" "paginaInicial" => "113" "paginaFinal" => "124" "serieFecha" => "2000" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence of neurodermatitis among school children in the Hannover administrative district" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Buser" 1 => "F. Von Bohlen" 2 => "P. Werner" 3 => "E. Gernhuber" 4 => "B.P. Robra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2008-1059436" "Revista" => array:6 [ "tituloSerie" => "Dtsch Med Wochenschr" "fecha" => "1993" "volumen" => "118" "paginaInicial" => "1141" "paginaFinal" => "1145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8354135" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Illness and social status. The special case of neurodermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Buser" 1 => "S. Werner" 2 => "P. Volk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gesundheitswesen" "fecha" => "1998" "volumen" => "60" "paginaInicial" => "311" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9676014" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood eczema: disease of the advantaged?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.C. Williams" 1 => "D.P. Strachan" 2 => "R. Hay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1994" "volumen" => "308" "paginaInicial" => "1132" "paginaFinal" => "1135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8173454" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The incidence of atopic dermatitis in school entrants is associated with individual life-style factors but not with local environmental factors in Hannover, Germany" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Werner" 1 => "K. Buser" 2 => "A. Kapp" 3 => "T. Werfel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2002" "volumen" => "147" "paginaInicial" => "95" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12100190" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hay fever, hygiene, and household size" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.P. Strachan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1989" "volumen" => "299" "paginaInicial" => "1259" "paginaFinal" => "1260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2513902" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cohort study of sibling effect, infectious diseases, and risk of atopic dermatitis during first 18 months of life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.S. Benn" 1 => "M. Melbye" 2 => "J. Wohlfahrt" 3 => "B. Bjorksten" 4 => "P. Aaby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.38069.512245.FE" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2004" "volumen" => "328" "paginaInicial" => "1223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15121716" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of dog ownership and genotype on immune development and atopy in infancy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Gern" 1 => "C.L. Reardon" 2 => "S. Hoffjan" 3 => "D. Nicolae" 4 => "Z. Li" 5 => "K.A. Roberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2003.11.017" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2004" "volumen" => "113" "paginaInicial" => "307" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14767447" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence of atopic diseases in three generations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Luoma" 1 => "A. Koivikko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Soc Med" "fecha" => "1982" "volumen" => "10" "paginaInicial" => "49" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6983720" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of allergic rhinitis and atopic dermatitis among children in four regions of Finland" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.T. Remes" 1 => "M. Korppi" 2 => "M. Majosaari" 3 => "A. Koivikko" 4 => "L. Soininen" 5 => "J. Pekkanen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1998" "volumen" => "53" "paginaInicial" => "682" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9700037" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atopic dermatitis in 5-6 year old Swedish children: cumulative incidence, point prevalence, and severity scoring" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Broberg" 1 => "A. Svensson" 2 => "M.P. Borres" 3 => "R. Berg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2000" "volumen" => "55" "paginaInicial" => "1025" "paginaFinal" => "1029" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11097311" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burden of allergic disease in the UK: secondary analysis of national databases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Gupta" 1 => "A. Sheikh" 2 => "D.P. Strachan" 3 => "H.R. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2222.2004.1935.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2004" "volumen" => "34" "paginaInicial" => "520" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15080802" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The UK working party's Diagnostic Criteria for Atopic Dermatitis. III independent hospital validation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.C. Williams" 1 => "P.G. Burney" 2 => "A.C. Pembroke" 3 => "R.J. Hay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "406" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7918017" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between atopy and bacterial infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Mucha" 1 => "F.M. Baroody" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Allergy Asthma Rep" "fecha" => "2003" "volumen" => "3" "paginaInicial" => "223" "paginaFinal" => "227" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PIAMA Study Group. Risk factors for atopic dermatitis in infants at high risk of allergy: the PIAMA study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kerkhof" 1 => "L.P. Koopman" 2 => "R.T. Van Strien" 3 => "A. Wijga" 4 => "H.A. Smit" 5 => "R.C. Aalberse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2003" "volumen" => "33" "paginaInicial" => "1336" "paginaFinal" => "1341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14519137" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de la dermatitis atópica en escolares de Cartagena y su relación con el sexo y la contaminación" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Martín Fernández-Mayoralas" 1 => "J.M. Martín Caballero" 2 => "L. García-Marcos Álvarez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Pediatr (Barc)" "fecha" => "2004" "volumen" => "60" "paginaInicial" => "555" "paginaFinal" => "560" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Climate and the prevalence of symptoms of asthma, allergic rhinitis and atopic eczema in children" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "ISAAC Phase Study Group" "etal" => false "autores" => array:5 [ 0 => "S.K. Weiland" 1 => "A. Husing" 2 => "D.P. Strachan" 3 => "P. Rzehak" 4 => "N. Pearce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Occup Environ Med" "fecha" => "2004" "volumen" => "61" "paginaInicial" => "609" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15208377" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perinatal predictors of atopic dermatitis occurring in the first six months of life" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. Moore" 1 => "S.L. Rifas-Shiman" 2 => "J.W. Rich-Edwards" 3 => "K.P. Kleinman" 4 => "C.A. Camargo Jr" 5 => "D.R. Gold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2004" "volumen" => "113" "paginaInicial" => "468" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14993536" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Family history and risk of atopic dermatitis in children up to 4 years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Bohme" 1 => "M. Wickman" 2 => "N.S. Lennart" 3 => "M. Svartengren" 4 => "O. Wahlgren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2003" "volumen" => "33" "paginaInicial" => "1226" "paginaFinal" => "1231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12956743" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "the ASPAC Study Team" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Wadonda-Kabondo" 1 => "J.A.C. Sterne" 2 => "J. Golding" 3 => "C.T.C. Kennedy" 4 => "C.B. Archer" 5 => "M.G.S. Dunnill" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/adc.2003.034033" "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "2004" "volumen" => "89" "paginaInicial" => "917" "paginaFinal" => "921" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15383434" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of breast-feeding on the development of atopic dermatitis on the first 3 years of life. Results from the GINI-birth cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Laubereau" 1 => "I. Brockow" 2 => "A. Zirngibl" 3 => "S. Koletzko" 4 => "A. Gruebl" 5 => "A. Von Berg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jpeds.2003.12.029" "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "2004" "volumen" => "144" "paginaInicial" => "602" "paginaFinal" => "607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15126993" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to pets and atopic dermatitis during the first two years of life. A cohort study" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "GINI study group" "etal" => true "autores" => array:6 [ 0 => "A. Zirngibl" 1 => "K. Franke" 2 => "U. Gehring" 3 => "A. Von Berg" 4 => "D. Berdel" 5 => "C.P. Bauer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Allergy Immunol" "fecha" => "2002" "volumen" => "13" "paginaInicial" => "394" "paginaFinal" => "401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12485314" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pet-keeping in early childhood and airway, nose and skin symptoms later in life" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "DBH Study Group" "etal" => false "autores" => array:4 [ 0 => "C.G. Bornehag" 1 => "J. Sundell" 2 => "L. Hagerhed" 3 => "S. Janson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "939" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12911425" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Environmental allergens and morbidity in atopic and non-atopic families" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Luoma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Paediatr Scand" "fecha" => "1984" "volumen" => "73" "paginaInicial" => "448" "paginaFinal" => "453" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6464733" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic diseases in relationship with environmental factors in a population of school children in Zagreb, Croatia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Stipic-Markovic" 1 => "B. Pevec" 2 => "M. Radulovic Pevec" 3 => "A. Custovic" 4 => "J. Predovic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arh Hig Rada Toksikol" "fecha" => "2004" "volumen" => "55" "paginaInicial" => "221" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15285472" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breastfeeding and risk of atopic dermatitis, by parental history of allergy, during the first 18 months of life" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Stabell Benn" 1 => "J. Wohlfahrt" 2 => "P. Aaby" 3 => "T. Westergaard" 4 => "E. Benfeldt" 5 => "K.F. Michaelsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/aje/kwh208" "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2004" "volumen" => "160" "paginaInicial" => "217" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15257994" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of atopic dermatitis in Italian schoolchildren" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Girolomoni" 1 => "D. Abeni" 2 => "C. Masini" 3 => "F. Sera" 4 => "F. Ayala" 5 => "A. Belloni-Fortina" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "420" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12752329" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000006300000006/v1_201307051457/S1695403305702460/v1_201307051457/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000006300000006/v1_201307051457/S1695403305702460/v1_201307051457/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403305702460?idApp=UINPBA00005H" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 15 | 25 |
| 2024 October | 61 | 54 | 115 |
| 2024 September | 62 | 53 | 115 |
| 2024 August | 84 | 90 | 174 |
| 2024 July | 40 | 54 | 94 |
| 2024 June | 47 | 50 | 97 |
| 2024 May | 52 | 63 | 115 |
| 2024 April | 55 | 49 | 104 |
| 2024 March | 48 | 36 | 84 |
| 2024 February | 35 | 45 | 80 |
| 2024 January | 35 | 39 | 74 |
| 2023 December | 46 | 23 | 69 |
| 2023 November | 43 | 55 | 98 |
| 2023 October | 30 | 34 | 64 |
| 2023 September | 24 | 28 | 52 |
| 2023 August | 35 | 33 | 68 |
| 2023 July | 31 | 41 | 72 |
| 2023 June | 32 | 51 | 83 |
| 2023 May | 42 | 34 | 76 |
| 2023 April | 31 | 41 | 72 |
| 2023 March | 27 | 42 | 69 |
| 2023 February | 29 | 24 | 53 |
| 2023 January | 23 | 36 | 59 |
| 2022 December | 33 | 36 | 69 |
| 2022 November | 68 | 55 | 123 |
| 2022 October | 36 | 54 | 90 |
| 2022 September | 28 | 57 | 85 |
| 2022 August | 38 | 80 | 118 |
| 2022 July | 28 | 76 | 104 |
| 2022 June | 33 | 101 | 134 |
| 2022 May | 30 | 65 | 95 |
| 2022 April | 29 | 64 | 93 |
| 2022 March | 58 | 72 | 130 |
| 2022 February | 32 | 83 | 115 |
| 2022 January | 53 | 47 | 100 |
| 2021 December | 36 | 73 | 109 |
| 2021 November | 63 | 88 | 151 |
| 2021 October | 41 | 81 | 122 |
| 2021 September | 26 | 82 | 108 |
| 2021 August | 28 | 53 | 81 |
| 2021 July | 27 | 52 | 79 |
| 2021 June | 20 | 34 | 54 |
| 2021 May | 26 | 49 | 75 |
| 2021 April | 49 | 96 | 145 |
| 2021 March | 66 | 99 | 165 |
| 2021 February | 60 | 37 | 97 |
| 2021 January | 31 | 32 | 63 |
| 2020 December | 46 | 37 | 83 |
| 2020 November | 30 | 24 | 54 |
| 2020 October | 42 | 16 | 58 |
| 2020 September | 20 | 5 | 25 |
| 2020 August | 31 | 16 | 47 |
| 2020 July | 53 | 22 | 75 |
| 2020 June | 41 | 10 | 51 |
| 2020 May | 39 | 46 | 85 |
| 2020 April | 24 | 25 | 49 |
| 2020 March | 26 | 28 | 54 |
| 2020 February | 30 | 22 | 52 |
| 2020 January | 34 | 27 | 61 |
| 2019 December | 39 | 25 | 64 |
| 2019 November | 38 | 22 | 60 |
| 2019 October | 33 | 30 | 63 |
| 2019 September | 31 | 30 | 61 |
| 2019 August | 40 | 25 | 65 |
| 2019 July | 83 | 39 | 122 |
| 2019 June | 85 | 27 | 112 |
| 2019 May | 130 | 45 | 175 |
| 2019 April | 150 | 59 | 209 |
| 2019 March | 71 | 34 | 105 |
| 2019 February | 43 | 17 | 60 |
| 2019 January | 37 | 16 | 53 |
| 2018 December | 29 | 21 | 50 |
| 2018 November | 45 | 27 | 72 |
| 2018 October | 54 | 24 | 78 |
| 2018 September | 14 | 12 | 26 |
| 2018 August | 1 | 0 | 1 |
| 2018 July | 4 | 0 | 4 |
| 2018 June | 2 | 0 | 2 |
| 2018 May | 1 | 0 | 1 |
| 2018 April | 11 | 0 | 11 |
| 2018 March | 9 | 0 | 9 |
| 2018 February | 8 | 0 | 8 |
| 2018 January | 9 | 0 | 9 |
| 2017 December | 10 | 0 | 10 |
| 2017 November | 10 | 0 | 10 |
| 2017 October | 13 | 0 | 13 |
| 2017 September | 8 | 0 | 8 |
| 2017 August | 7 | 0 | 7 |
| 2017 July | 12 | 1 | 13 |
| 2017 June | 12 | 25 | 37 |
| 2017 May | 17 | 29 | 46 |
| 2017 April | 12 | 19 | 31 |
| 2017 March | 11 | 26 | 37 |
| 2017 February | 6 | 14 | 20 |
| 2017 January | 9 | 10 | 19 |
| 2016 December | 9 | 25 | 34 |
| 2016 November | 22 | 33 | 55 |
| 2016 October | 31 | 31 | 62 |
| 2016 September | 24 | 21 | 45 |
| 2016 August | 31 | 16 | 47 |
| 2016 July | 22 | 23 | 45 |
| 2016 June | 2 | 20 | 22 |
| 2016 May | 1 | 47 | 48 |
| 2016 April | 2 | 0 | 2 |
| 2016 March | 2 | 18 | 20 |
| 2016 February | 3 | 0 | 3 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 2 | 23 | 25 |
| 2015 November | 2 | 0 | 2 |
| 2015 October | 5 | 29 | 34 |
| 2015 September | 4 | 0 | 4 |
| 2015 August | 1 | 21 | 22 |
| 2015 July | 10 | 16 | 26 |
| 2015 June | 12 | 0 | 12 |
| 2015 May | 8 | 0 | 8 |
| 2015 April | 27 | 26 | 53 |
| 2015 March | 16 | 18 | 34 |
| 2015 February | 15 | 14 | 29 |
| 2015 January | 30 | 2 | 32 |
| 2014 December | 47 | 4 | 51 |
| 2014 November | 37 | 4 | 41 |
| 2014 October | 31 | 5 | 36 |
| 2014 September | 35 | 4 | 39 |
| 2014 August | 53 | 2 | 55 |
| 2014 July | 73 | 7 | 80 |
| 2014 June | 104 | 3 | 107 |
| 2014 May | 122 | 6 | 128 |
| 2014 April | 73 | 3 | 76 |
| 2014 March | 65 | 6 | 71 |
| 2014 February | 66 | 11 | 77 |
| 2014 January | 80 | 6 | 86 |
| 2013 December | 103 | 6 | 109 |
| 2013 November | 112 | 6 | 118 |
| 2013 October | 112 | 6 | 118 |
| 2013 September | 64 | 9 | 73 |
| 2013 August | 70 | 16 | 86 |
| 2013 July | 42 | 6 | 48 |
| 2013 June | 3 | 4 | 7 |
| 2013 May | 5 | 1 | 6 |
| 2013 April | 6 | 2 | 8 |
| 2013 March | 5 | 1 | 6 |
| 2013 February | 22 | 1 | 23 |
| 2013 January | 19 | 0 | 19 |
| 2012 December | 13 | 0 | 13 |
| 2012 November | 17 | 1 | 18 |
| 2012 October | 3 | 1 | 4 |
| 2012 September | 2 | 0 | 2 |
| 2012 August | 2 | 0 | 2 |
| 2005 December | 2151 | 0 | 2151 |
Show all
