Originales
Estudio de la morfología y la función renal en niños diagnosticados de enuresis nocturna. Su relación con la sensibilidad o la resistencia a la desmopresina
Study of renal morphology and function in children with nocturnal enuresis. Relationship with sensitivity or resistance to desmopressin
C.L. Marrero Pérez, V. García Nieto
, M.I. Luis Yanes
Corresponding author
vgarcia@comtf.es
Correspondencia: Dr. V. García Nieto. Unidad de Nefrología Pediátrica. Hospital Universitario Nuestra Señora de Candelaria. Ctra. del Rosario, s/n. 38010 Santa Cruz de Tenerife. España.
Correspondencia: Dr. V. García Nieto. Unidad de Nefrología Pediátrica. Hospital Universitario Nuestra Señora de Candelaria. Ctra. del Rosario, s/n. 38010 Santa Cruz de Tenerife. España.
Unidad de Nefrología Pediátrica. Hospital Universitario Nuestra Señora de Candelaria. Santa Cruz de Tenerife. España
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Su relación con la sensibilidad o la resistencia a la desmopresina" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "475" "paginaFinal" => "479" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C.L. Marrero Pérez, V. García Nieto, M.I. Luis Yanes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C.L." "apellidos" => "Marrero Pérez" ] 1 => array:4 [ "nombre" => "V." "apellidos" => "García Nieto" "email" => array:1 [ 0 => "vgarcia@comtf.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:2 [ "nombre" => "M.I." "apellidos" => "Luis Yanes" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Nefrología Pediátrica. Hospital Universitario Nuestra Señora de Candelaria. Santa Cruz de Tenerife. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. V. García Nieto. Unidad de Nefrología Pediátrica. Hospital Universitario Nuestra Señora de Candelaria. Ctra. del Rosario, s/n. 38010 Santa Cruz de Tenerife. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Study of renal morphology and function in children with nocturnal enuresis. Relationship with sensitivity or resistance to desmopressin" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-08-31" "fechaAceptado" => "2005-08-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186258" "palabras" => array:5 [ 0 => "Enuresis nocturna" 1 => "Hipercalciuria" 2 => "Urolitiasis" 3 => "Herencia" 4 => "Desmopresina" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186257" "palabras" => array:5 [ 0 => "Nocturnal enuresis" 1 => "Hypercalciuria" 2 => "Urolithiasis" 3 => "Inheritance" 4 => "Desmopressin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p class="elsevierStyleSimplePara elsevierViewall">En los últimos años, se ha descrito que, con frecuencia, los niños con enuresis nocturna presentan hipercalciuria. Así mismo, se acaba de comunicar que los niños con enuresis nocturna resistente a desmopresina tienen una capacidad de concentración renal superior a la de aquellos pacientes con enuresis sensible a ese fármaco.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar la función renal y la eliminación urinaria de calcio y registrar los antecedentes familiares de enuresis y de litiasis en un grupo de niños enuréticos respondedores y resistentes a desmopresina controlados en nuestro hospital.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Cohorte de 60 pacientes, 42 varones y 18 mujeres, que fueron remitidos al hospital por padecer enuresis nocturna.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se detectó hipercalciuria en 26 niños (43,3 %) e hipocitraturia en ocho (13,3 %). La frecuencia de hipercalciuria fue superior en los pacientes resistentes con respecto a los sensibles a desmopresina, sin diferencias estadísticamente significativas. En 11 niños se detectaron anomalies morfológicas ecográficas renales. No se comprobaron diferencias en el manejo renal del agua al distribuir a los pacientes según el grado de sensibilidad a la desmopresina.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En nuestra serie se demuestra la elevada frecuencia de hipercalciuria en niños con enuresis nocturna. No observamos diferencias en la osmolalidad urinaria maxima entre los niños sensibles y los resistentes a la desmopresina.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">In the last few years, there have been reports that children with nocturnal enuresis frequently have hypercalciuria.Likewise, children with desmopressin-resistant enuresis have recently been reported to have a higher renal concentration capacity than patients with desmopressinsensitive enuresis.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To study renal function and urinary calcium excretion and to register familial history of enuresis and urolithiasis in a group of children with enuresis, whether responders or nonresponders to desmopressin, followed-up in our hospital.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A cohort of 60 patients (42 boys and 18 girls) who were referred to the hospital because of nocturnal enuresis.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Hypercalciuria was detected in 26 children (43.3 %) and hypocitraturia in eight (13.3 %). The frequency of hyper-calciuria was higher in desmopressin-resistant patients than in desmopressin-sensitive patients, but this difference was not statistically significant. Sonographic renal morphological anomalies were detected in 11 children (18.3 %). No differences in renal handling of water were detected when the patients were distributed according to the grade of sensitivity to desmopressin.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In our cohort we found a high frequency of hypercalciuria in children with nocturnal enuresis. No differences were observed in maximal urinary osmolality among desmopressin-resistant and desmopressin-sensitive children.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 17 | 23 |
| 2024 October | 51 | 56 | 107 |
| 2024 September | 33 | 48 | 81 |
| 2024 August | 48 | 87 | 135 |
| 2024 July | 41 | 51 | 92 |
| 2024 June | 44 | 32 | 76 |
| 2024 May | 51 | 51 | 102 |
| 2024 April | 32 | 39 | 71 |
| 2024 March | 38 | 53 | 91 |
| 2024 February | 36 | 37 | 73 |
| 2024 January | 30 | 29 | 59 |
| 2023 December | 24 | 21 | 45 |
| 2023 November | 24 | 40 | 64 |
| 2023 October | 30 | 26 | 56 |
| 2023 September | 18 | 25 | 43 |
| 2023 August | 27 | 22 | 49 |
| 2023 July | 30 | 52 | 82 |
| 2023 June | 37 | 43 | 80 |
| 2023 May | 32 | 22 | 54 |
| 2023 April | 23 | 19 | 42 |
| 2023 March | 22 | 37 | 59 |
| 2023 February | 19 | 33 | 52 |
| 2023 January | 16 | 31 | 47 |
| 2022 December | 32 | 31 | 63 |
| 2022 November | 40 | 47 | 87 |
| 2022 October | 29 | 51 | 80 |
| 2022 September | 20 | 43 | 63 |
| 2022 August | 38 | 54 | 92 |
| 2022 July | 25 | 45 | 70 |
| 2022 June | 20 | 43 | 63 |
| 2022 May | 31 | 41 | 72 |
| 2022 April | 19 | 40 | 59 |
| 2022 March | 26 | 48 | 74 |
| 2022 February | 25 | 39 | 64 |
| 2022 January | 23 | 49 | 72 |
| 2021 December | 25 | 57 | 82 |
| 2021 November | 24 | 60 | 84 |
| 2021 October | 27 | 73 | 100 |
| 2021 September | 22 | 63 | 85 |
| 2021 August | 25 | 41 | 66 |
| 2021 July | 23 | 40 | 63 |
| 2021 June | 14 | 50 | 64 |
| 2021 May | 35 | 34 | 69 |
| 2021 April | 50 | 60 | 110 |
| 2021 March | 66 | 23 | 89 |
| 2021 February | 74 | 14 | 88 |
| 2021 January | 50 | 17 | 67 |
| 2020 December | 36 | 23 | 59 |
| 2020 November | 22 | 12 | 34 |
| 2020 October | 18 | 10 | 28 |
| 2020 September | 26 | 10 | 36 |
| 2020 August | 9 | 16 | 25 |
| 2020 July | 20 | 11 | 31 |
| 2020 June | 18 | 10 | 28 |
| 2020 May | 39 | 12 | 51 |
| 2020 April | 18 | 13 | 31 |
| 2020 March | 20 | 17 | 37 |
| 2020 February | 23 | 9 | 32 |
| 2020 January | 25 | 21 | 46 |
| 2019 December | 64 | 37 | 101 |
| 2019 November | 20 | 21 | 41 |
| 2019 October | 17 | 20 | 37 |
| 2019 September | 19 | 21 | 40 |
| 2019 August | 26 | 21 | 47 |
| 2019 July | 32 | 31 | 63 |
| 2019 June | 30 | 29 | 59 |
| 2019 May | 38 | 31 | 69 |
| 2019 April | 47 | 51 | 98 |
| 2019 March | 13 | 21 | 34 |
| 2019 February | 29 | 21 | 50 |
| 2019 January | 17 | 14 | 31 |
| 2018 December | 18 | 23 | 41 |
| 2018 November | 36 | 33 | 69 |
| 2018 October | 44 | 14 | 58 |
| 2018 September | 22 | 8 | 30 |
| 2018 July | 5 | 0 | 5 |
| 2018 June | 1 | 0 | 1 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 7 | 0 | 7 |
| 2018 March | 12 | 0 | 12 |
| 2018 February | 6 | 0 | 6 |
| 2018 January | 5 | 0 | 5 |
| 2017 December | 9 | 0 | 9 |
| 2017 November | 14 | 0 | 14 |
| 2017 October | 13 | 0 | 13 |
| 2017 September | 9 | 1 | 10 |
| 2017 August | 6 | 0 | 6 |
| 2017 July | 11 | 1 | 12 |
| 2017 June | 14 | 12 | 26 |
| 2017 May | 18 | 21 | 39 |
| 2017 April | 10 | 7 | 17 |
| 2017 March | 5 | 8 | 13 |
| 2017 February | 8 | 16 | 24 |
| 2017 January | 8 | 13 | 21 |
| 2016 December | 13 | 9 | 22 |
| 2016 November | 22 | 12 | 34 |
| 2016 October | 26 | 16 | 42 |
| 2016 September | 27 | 27 | 54 |
| 2016 August | 35 | 18 | 53 |
| 2016 July | 28 | 18 | 46 |
| 2016 June | 1 | 0 | 1 |
| 2016 February | 2 | 12 | 14 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 0 | 13 | 13 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 13 | 9 | 22 |
| 2015 June | 12 | 11 | 23 |
| 2015 May | 16 | 0 | 16 |
| 2015 April | 7 | 4 | 11 |
| 2015 March | 13 | 5 | 18 |
| 2015 February | 9 | 4 | 13 |
| 2015 January | 14 | 1 | 15 |
| 2014 December | 26 | 4 | 30 |
| 2014 November | 16 | 4 | 20 |
| 2014 October | 27 | 2 | 29 |
| 2014 September | 25 | 4 | 29 |
| 2014 August | 36 | 4 | 40 |
| 2014 July | 57 | 2 | 59 |
| 2014 June | 65 | 5 | 70 |
| 2014 May | 66 | 4 | 70 |
| 2014 April | 61 | 3 | 64 |
| 2014 March | 50 | 11 | 61 |
| 2014 February | 58 | 11 | 69 |
| 2014 January | 47 | 7 | 54 |
| 2013 December | 54 | 10 | 64 |
| 2013 November | 45 | 6 | 51 |
| 2013 October | 55 | 6 | 61 |
| 2013 September | 34 | 14 | 48 |
| 2013 August | 46 | 8 | 54 |
| 2013 July | 32 | 6 | 38 |
| 2013 June | 1 | 2 | 3 |
| 2013 May | 3 | 2 | 5 |
| 2013 April | 6 | 1 | 7 |
| 2013 March | 6 | 1 | 7 |
| 2013 February | 20 | 1 | 21 |
| 2013 January | 5 | 0 | 5 |
| 2012 December | 7 | 0 | 7 |
| 2012 November | 4 | 0 | 4 |
| 2012 October | 8 | 1 | 9 |
| 2012 September | 2 | 1 | 3 |
| 2005 December | 3453 | 0 | 3453 |
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