Journal Information
Vol. 58. Issue 6.
Pages 529-537 (1 June 2003)
Share
Share
Download PDF
More article options
Vol. 58. Issue 6.
Pages 529-537 (1 June 2003)
Full text access
Crecimiento en niños con artritis idiopática juvenil
Growth in children with juvenile idiopathic arthritis
Visits
12642
J. García-Consuegra Molinaa,
Corresponding author
reumaped.hulp@salud.madrid.org

Correspondencia: Unidad de Reumatología Pediátrica. Hospital Infantil La Paz. P.° de la Castellana, 261. 28046 Madrid. España.
, R. Merino Muñoza, R. Lama Moreb, J. Coya Viñac, R. Gracia Bouthelierd
a Unidades de aReumatología Pediátric. Hospital Universitario Infantil La Paz. Madrid. España.
b Nutrición Pediátrica. Hospital Universitario Infantil La Paz. Madrid. España.
c Servicios de Medicina Nuclear. Hospital Universitario Infantil La Paz. Madrid. España.
d Endocrinología Pediátrica. Hospital Universitario Infantil La Paz. Madrid. España.
This item has received
Article information
Introducción

La artritis idiopática juvenil es una enfermedad inflamatoria crónica que precisa con frecuencia corticoterapia. El retraso del crecimiento puede ser un problema importante en estos pacientes.

Objetivo

Estudiar el crecimiento de los niños con artritis idiopática juvenil y analizar los factores implicados en las alteraciones de éste.

Métodos

Se estudiaron 91 pacientes con artritis idiopática juvenil, seguidos durante al menos un año. Se realizó un estudio de corte transversal, uno longitudinal retrospectivo y otro prospectivo. Se valoró la talla en la primera consulta, en el estudio transversal y un año antes. Se calculó la velocidad de crecimiento. Se estudiaron parámetros relacionados con la actividad de la enfermedad, con la corticoterapia, con el estado nutritivo, con la situación hormonal y la densidad mineral ósea (DMO). Se realizó un estudio de correlación y un análisis de regresión multivariante.

Resultados

La talla fue inferior o igual a –2 desviaciones estándar (DE) en el 14,3% del total de los pacientes y en el 55,6% de las formas sistémicas. Los factores asociados de forma independiente con la talla fueron la dosis total de corticoids recibida, la clase funcional, el índice nutricional, la DMO y la edad de comienzo de la enfermedad. La velocidad de crecimiento fue inferior a lo normal en el 25,3% del total y en el 61 % del grupo sistémico y los factores asociados de forma independiente con ella fueron la dosis de corticoide y el número de articulaciones inflamadas.

Conclusiones

El retraso en el crecimiento en pacientes con arthritis idiopática juvenil se asoció a factores relacionados con la enfermedad, con la corticoterapia, con el estado nutritivo, con la DMO y con el comienzo precoz de la enfermedad.

Palabras clave:
Artritis idiopática juvenil
Crecimiento
Nutrición
Osteoporosis
growth in children with juvenile idiopathic arthritis
Introduction

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that often requires steroid therapy. Growth retardation can be a serious complication in some of these patients.

Objective

To study linear growth in patients with JIA and evaluate the factors involved in its disturbance.

Methods

We studied 91 patients with JIA with a follow-up of at least one year. A cross sectional study, a longitudinal retrospective study, and a longitudinal prospective study were performed. Height in the first consultation, in the cross sectional study, and one year previously was evaluated. Height velocity (HV) was calculated. Several parameters related to disease activity, corticosteroid therapy, nutritional and hormonal status, and bone mineral density (BMD) were analyzed. A correlation study and multivariate regression analysis were carried out.

Results

Height was # ≤2 SD in 14.3 % of the series and in 55.6% of the systemic group. Variables independently associated with height were total corticosteroid dose, functional class, nutritional index, BMD, and age at onset of the disease. HV was # ≤2 SD in 25.3 % of the series and in 61 % of the systemic group. Variables independently associated with HV were corticosteroid dose and the number of swollen joints.

Conclusions

Growth retardation in patients with JIA was associated with factors related to the disease, corticosteroid therapy, nutritional status, BMD, and earlier onset of the disease.

Key words:
Juvenile idiopathic arthritis
Growth
Nutrition
Osteoporosis
Full text is only aviable in PDF
BibliografÍa
[1.]
E.J. Brewer, J. Bass, J. Baum, J.T. Cassidy, C. Fink, J. Jacobs, et al.
Current proposed revision of JRA criteria.
Arthtitis Rheum, 20 (1977), pp. 195-199
[2.]
B.M. Ansell.
Chronic arthritis in childhood.
Ann Rheum Dis, 37 (1978), pp. 107-120
[3.]
C.W. Fink.
and the task force for classification criteria. Proposal for the development of classification criteria for idiopathic arthritides of childhood.
J Rheumatol, 22 (1995), pp. 1566-1569
[4.]
R.E. Petty, T.R. Southwood, J. Baum, E. Bhettay, D.N. Glass, P. Manners, et al.
Revision of the proposed classification criteria for juvenile idiopathic arthritis.
Durban 1997 J Rheumatol, 25 (1998), pp. 1991-1994
[5.]
I. Foeldvari, M. Bidde.
Validation of the proposed ILAR classification criteria for juvenile idiopathic arthritis. International League of Associations for Rheumatology.
J Rheumatol, 27 (2000), pp. 1069-1072
[6.]
R. Merino, J. De Inocencio, J. García-Consuegra.
Evaluation of ILAR classification criteria for juvenile idiopathic arthritis in spanish children.
J Rheumatol, 28 (2001), pp. 2731-2736
[7.]
M. Dougados, S. Linden, R. Juhlin, B. Huitfeldt, B. Amor, A. Calin, et al.
The European Spondyloarthropathy Study Group. The European Spondyloarthropathy Study Group preliminary criteria for the classification of Spondyloarthropathy.
Arthritis Rheum, 34 (1991), pp. 1218-1227
[8.]
T.R. Southwood, R.E. Petty, P.N. Malleson, E.A. Delgado, D.W.C. Hunt, B. Wood, et al.
Psoriatic arthritis in children.
Arthritis Rheum, 32 (1989), pp. 1007-1013
[9.]
M. Hernández, J. Castellet, J.L. Narvaíza, J.M. Rincón, E. Ruiz, E. Sánchez, et al.
Garsi, (1988),
[10.]
M. Hernández Rodríguez.
Valoración del estado de nutrición.
Tratado de Nutrición, pp. 601-626
[11.]
W.F. Blum, M.B. Ranke, K. Kietzmann, E. Gauggel, H. Zeisel, J.R. Bierich.
A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency.
J Clin Endocrinol Metab, 70 (1990), pp. 1292-1298
[12.]
W.F. Blum, K. Albertsson-Wikland, S. Rosberg, M.B. Ranke.
Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion.
J Clin Endocrinol Metab, 76 (1993), pp. 1601-1606
[13.]
A. Juul, P. Dalgaard, W.F. Blum, P. Bang, K. Hall, K.F. Michaelsen, et al.
Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: The relation to IGF-1, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maduration.
J Clin Endocrinol Metab, 80 (1995), pp. 2534-2542
[14.]
A. Carrascosa, L. Del Río, M. Gussinyé, D. Yeste, L. Audí.
Mineralización del esqueleto óseo durante la infancia y adolescencia. Factores reguladores y patrones de normalidad.
An Esp Pediatr, 40 (1992), pp. 246-252
[15.]
G.F. Still.
On a form of chronic joint disease in children. Trans R Med Chir Soc 1897,80:1-13 [reprinted in.
Am J Dis Child, 132 (1978), pp. 195-200
[16.]
B.M. Ansell, E.G.L. Bywaters.
Growth in Still'S disease.
Ann Rheum Dis, 15 (1956), pp. 295-319
[17.]
B.H. Bernstein, D. Stobie, B.H. Singsen, K. Koster-King, H.K. Kornreich, V. Hanson.
Growth retardation in juvenile rheumatoid arthritis (JRA).
Arthritis Rheum, 20 (Suppl) (1977), pp. 212-226
[18.]
P.J. Hashkes, D.J. Lovell.
Why are children with juvenile rheumatoid arthritis smallα.
pp. 139-153
[19.]
D. Simon, C. Fernando, P. Czernichow, A.M. Prieur.
Linear growth and final height in patients with systemic juvenile idipathic arthritis treated with longterm glucocorticoids.
J Rheumatol, 29 (2002), pp. 1296-1300
[20.]
J.T. Cassidy, L.S. Hillman.
Abnormalities in skeletal growth in children with juvenile rheumatoid arthritis.
Rheum Dis Clin North Am, 23 (1997), pp. 499-522
[21.]
C. Polito, C.G. Strano, A.N. Olivieri, M. Alessi, C.S. Iammarrone, N. Todisco, et al.
Growth retardation in non-steroid treated juvenile rheumatoid arthritis.
Scand J Rheumatol, 26 (1997), pp. 99-103
[22.]
M.T. Saha, P. Verronen, P. Laippala, H.L. Lenko.
Growth of prepubertal children with juvenile chronic arthritis.
Acta Paediatr, 88 (1999), pp. 724-728
[23.]
L.E. Underwood.
Growth retardation in chronic diseases: Possible mechanism.
Acta Paediatr, (1999), pp. 93-99
[24.]
P.M.M. Woo.
Growth retardation and osteoporosis in juvenile chronic arthritis.
Clin Exp Rheumatol, 12(Suppl 10) (1994), pp. 87-90
[25.]
J.S. Hyams, D.E. Carey.
Corticosteroids and growth.
J Pediatr, 113 (1988), pp. 249-254
[26.]
B.M. Ansell.
Overview of the side effects of corticosteroids therapy.
Clin Exp Rheumatol, 9(Suppl) (1991), pp. 19-20
[27.]
R.E.S. Gray, S.M. Doherty, J. Galloway, L. Coulton, M. De Broe, J.A. Kanis.
A double-blind study of deflazacort and prednisone in patients with chronic inflammatory disorders.
Arthritis Rheum, 34 (1991), pp. 287-295
[28.]
J. Loftus, R. Allen, R. Hesp, J. David, D.M. Reid, D.J. Wright, et al.
Randomized, double-blind trial of deflazacort versus predni sone in juvenile chronic (or rheumatoid) arthritis. A relative bone-sparing effect of deflazacort.
Pediatrics, 88 (1991), pp. 428-436
[29.]
U. Johansson, S. Portinsson, A. Akesson, H. Svantesson, P.A. Öckerman, B. Akesson.
Nutritional status in girls with juvenile chronic arthritis.
Hum Nutr Clin Nutr, 40C (1986), pp. 57-67
[30.]
C.J. Henderson, D.J. Lovell, D. Gregg.
A nutritional screening test for use in children and adolescent with juvenile rheumatoid arthritis.
J Rheumatol, 19 (1992), pp. 1276-1281
[31.]
M.C. Bacon, P.H. White, D.J. Raiten, N. Craft, S. Margolis, O.A. Levander, et al.
Nutritional status and growth in juvenile rheumatoid arthritis.
Semin Arthritis Rheum, 20 (1990), pp. 97-106
[32.]
R.C. Allen, M. Jiménez, C.T. Cowell.
Insulin-like growth factor and growth hormone secretion in juvenile chronic arthritis.
Ann Rheum Dis, 50 (1991), pp. 602-606
[33.]
U.M. Davies, M. Rooney, M.A. Preece, B.M. Ansell, P. Woo.
Treatment of growth retardation in juvenile chronic arthritis with recombinant human growth hormone.
J Rheumatol, 21 (1994), pp. 153-158
[34.]
U.M. Davies, J. Jones, J. Reeve, C. Camacho-Hubner, A. Charlett, B.M. Ansell, et al.
Juvenile Rheumatoid Arthritis. Effects of disease activity and recombinant human growth hormone on insuline-like growth factor 1, insuline-like growth factor binding proteins 1 and 3, and osteocalcin.
Arthritis Rheum, 40 (1997), pp. 332-340
[35.]
S. Bechtold, P. Ripperger, D. Mühlbayer, H. Truckenbrodt, R. Häfner, O. Butenandt, et al.
Therapy in juvenile chronic arthritis. Results of a two-year controlled study on growth and bone.
J Clin Endocrinol Metab, 86 (2001), pp. 5737-5744
[36.]
G. Touati, A.M. Prieur, J.C. Ruiz, M. Noel, P. Czernichow.
Beneficial effects of one year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition.
J Clin Endocrinol Metab, 83 (1998), pp. 403-409
[37.]
G. Touati, J.C. Ruiz, D. Porquet, C. Kindermans, A.M. Prieur, P. Czernichow.
Effects on bone metabolism of one year recombinant human growth hormone administration to children with juvenile chronic arthritis undergoing chronic steroid therapy.
J Rheumatol, 27 (2000), pp. 1287-1293
[38.]
A.E. Bennet, E.D. Silverman, J.J. Miller III, R.L. Hintz.
Insuline-like growth factors I and II in children with systemic onset juvenile arthritis.
J Rheumatol, 15 (1988), pp. 655-658
[39.]
R. Cimaz, B. Rusconi, B. Cesana, A. Buoncompagni, F. Corona, M. Gattinara, et al.
A multicenter study on insulin-like growth factor-I serum levels in children with chronic inflammatory diseases.
Clin Exp Rheumatol, 15 (1997), pp. 691-696
[40.]
B.D. Warady, C.B. Lindsley, R.G. Robinson, B.P. Lukert.
Effects of nutritional supplementation on bone mineral status of children with rheumatic diseases receiving corticosteroids therapy.
J Rheumatol, 21 (1994), pp. 530-535
[41.]
A.M. Reed, M. Haugen, L.M. Pachman, C.B. Langman.
Repair of osteopenia in children with juvenile rheumatoid arthritis.
J Pediatr, 122 (1993), pp. 693-696
[42.]
A. Kotaniemi, A. Savolainen, H. Kautiainen, H. Kröger.
Estimatio of central osteopenia in children with chronic polyarthritis treated with glucocorticoids.
Pediatrics, 91 (1993), pp. 1127-1130
[43.]
C. Polito, C.G. Strano, L. Rea, M. Alessio, C.S. Iammarrone, N. Todisco, et al.
Reduced bone mineral content and normal serum osteocalcin in non-steroid-treated patients with juvenile rheumatoid arthritis.
Ann Rheum Dis, 54 (1995), pp. 193-196
[44.]
P.H. Pepmueller, J.T. Cassidy, S.H. Allen, L.S. Hillman.
Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis.
Arthritis Rheum, 39 (1996), pp. 746-757
[45.]
J. Reeve, J. Loftus, R. Hesp, B.M. Ansell, D.J. Wright, P.M. Woo.
Biochemical prediction of changes in spinal bone mass in juvenile chronic (or rheumatoid) arthritis treated with glucocorticoids.
J Rheumatol, 20 (1993), pp. 1189-1195
Copyright © 2003. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?