Research paperReperfusion injury and reactive oxygen species: The evolution of a concept☆
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Graphical abstract
Abbreviations
A/R
anoxia-reoxygenation
AP-1
activator protein-1
BH4
tetrahydrobiopterin
BM
bone marrow
CoQ
coenzyme Q
CuZn SOD
copper–zinc superoxide dismutase
∆ψ
membrane potential
DCF
dichlorofluorescein
DHE
dihydroethidine
DHFR
dihydrofolate reductase
DHR
dihyrdrorhodamine
DPI
diphenyliodonium
Duox
dual oxidase
EC
endothelial cell
EC-SOD
extracellular superoxide dismutase
ESR
electron spin resonance
ETC
electron transport chain
FAD
flavin adenine dinucleotide
FADH2
reduced FAD
GAG
glycosaminoglycans
α-GPD
α-glycerophosphate dehydrogenase
GPx
glutathione peroxidase
GTPCH
guanosine triphosphate cyclohydrolase I
H2O2
hydrogen peroxide
H/R
hypoxia-reoxygenation
HIF-1α
hypoxia inhibitory factor-1α
I/R
ischemia-reperfusion
IMAC
inner membrane anion channel
ICAM-1
intercellular adhesion molecule-1
IFN-γ
interferon-γ
IL-1β
interleukin-1beta
IL-6
interleukin-6
α-KDH
α-ketoglutarate dehydrogenase
LTB4
leukotriene B4
MAO
monoamine oxidase
MnSOD
manganese superoxide dismutase
MPTP
mitochondrial permeability transition pore
mtROS
mitochondrial reactive oxygen species
NAD+
Nicotinamide adenine dinucleotide (oxidized)
NADH
Nicotinamide adenine dinucleotide (reduced)
NADPH
Nicotinamide adenine dinucleotide phosphate
NFkB
nuclear factor kappa-B
NNT
NADP-transhydrogenase
Nox
NADPH oxidase
NO
nitric oxide
nitrite ion
NOS
nitric oxide synthase
eNOS
endothelial nitric oxide synthase
iNOS
inducible nitric oxide synthase
mtNOS
mitochondrial nitric oxide synthase
nNOS
neuronal nitric oxide synthase
O2
molecular oxygen
superoxide anion
PDH
pyruvate dehydrogenase
PKC
protein kinase C
PR-39
synthetic peptide inhibitor of Nox
Prx
peroxiredoxin
PAF
platelet activating factor
PEG-
polyethylene glycol conjugated
RBC
red blood cell
RET
reverse electron transport
RIRR
ROS-induced ROS release
ROS
reactive oxygen species
SOD
superoxide dismutase
TCA
tricarboxyl acid
TNF-α
tumor necrosis factor-α
Trx
thioredoxin
UCP
uncoupling protein
XDH
xanthine dehydrogenase
XO
xanthine oxidase
XOR
xanthine oxidoreductase (XD+XO)
Keywords
Ischemia-reperfusion
Hypoxia-reoxygenation
Xanthine oxidase
NADPH oxidase
Uncoupled nitric oxide synthase
Mitochondria
Cited by (0)
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Supported by a Grant from the National Heart Lung and Blood Institute (HL26441) and the KACST of Saudi Arabia (11-MED1672-20).
Copyright © 2015 The Authors. Published by Elsevier B.V.