Original ArticlesA Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia
Section snippets
Methods
Preterm infants born at or below 30 weeks of gestation at the Children's and Women's Health Center of British Columbia (Vancouver, Canada) were eligible after admission to the neonatal intensive care unit, and recruited following written consent from their parent or legal guardian. The Children's and Women's Health Center is the only pediatric hospital in British Columbia and the main provincial tertiary care referral center. Exclusion criteria were an early anticipated demise (<72 hours) and
Results
During the study period, 154 infants were eligible and 65 were enrolled. Three infants died before 36 weeks of PMA and were, therefore, excluded from the analysis: 1 infant died of bacterial sepsis, 1 of necrotizing enterocolitis, and 1 from a severe intracranial hemorrhage. Thirty-two of the 62 infants (52%) in the study had BPD. Clinical characteristics were similar between infants with and without BPD, except for gestational age, birth weight, and use of postnatal corticosteroids (Table I).
Discussion
We conducted a detailed temporal analysis to precisely delineate when inflammation occurs in infants with BPD. Our data reveal that inflammation occurred shortly after birth and was sustained, with gradual attenuation over the early neonatal period. This inflammation preceded clinical symptoms of BPD, which directly supports a role of inflammation in the BPD lung insult. The analysis of markers of BPD at high temporal resolution provides a clearer representation of inflammation in relation to
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2022, Early Human DevelopmentCitation Excerpt :As neonatal resuscitation is currently more widely offered to infants born at earlier gestations such as 22 weeks [4], ongoing research to identify new treatments is crucial to reduce the incidence and long-term impact of BPD. BPD is a multifactorial disease involving inflammation and arrest in lung growth and development, which are currently the main targets of antenatal and postnatal preventative interventions [5–8]. Owing to their anti-inflammatory action, corticosteroids have been extensively studied and administered to preterm neonates with established severe BPD as they result in short term outcome improvements.
Early diagnostic value of C-reactive protein as an inflammatory marker for moderate-to-severe bronchopulmonary dysplasia in premature infants with birth weight less than 1500 g
2022, International ImmunopharmacologyCitation Excerpt :Therefore, CRP has been extensively studied in a variety of neonatal diseases, including neonatal sepsis, patent ductus arteriosus, meconium aspiration, periventricular and intraventricular hemorrhage, and perinatal asphyxia [23–28]. Leroy et al. [29] studied 62 premature infants with an average gestational age of 27 weeks and found that the inflammation of BPD appeared before clinical symptoms, which occurred shortly after birth and gradually subsided 2 weeks after birth. Chang et al. [30] studied premature infants with a gestational age < 30 weeks and found that non-infectious systemic inflammatory reactions occurred in preterm infants requiring intensive care within 72 h after birth.
Salivary cytokine — A non-invasive predictor for bronchopulmonary dysplasia in premature neonates
2021, CytokineCitation Excerpt :In placental tissue, lower IL-10 levels were found associated with increased BPD risk and the IL-6 levels showed no significant association [42]. Several studies in neonatal serum biomarkers, including a large study from NICHD group, found higher IL-6, IL-8, IL-10, G-CSF and lower IL-4, IL-5, IL-17 concentrations in extremely low birth weight preterm neonates who died or developed BPD; after adjusting for other cytokines and clinical variables by multivariate logistic regression, they found higher IL-1β, IL-6, IL-8, IL-10, and IFN-γ concentrations and lower IL-17, RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and TNF-β concentrations in those who developed BPD/death [2,3,42,46,47], which were partially consistent with our salivary results before and after adjustment for GA, ANC, and ABE. With these similarities, salivary cytokine detection showed the potential of supporting or replacing other invasive cytokine collecting methods.
PERSISTENT PERINATAL INFLAMMATORY SYNDROME OF EXTREME PREMATURITY. IMPORTANT MORBIDITY AND MORTALITY FACTOR. PART II: MULTISYSTEMIC INVOLVEMENT
2021, Revista Medica Clinica Las Condes
Funded in part by the Molly Towell Perinatal Research Foundation and by the Canadian Institutes of Health Research (MOP-110938 to P.L.). P.L. received salary support from a BC Children's Hospital Investigator Grant Award and a Career Investigator Award from the Michael Smith Foundation for Health Research. The authors declare no conflicts of interest.
Portions of this study published in abstract form at the Pediatric Academic Societies Meeting, April 25-28, 2015, San Diego, California.
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Present address: Centre Hospitalier Mère-Enfant de l'Université Laval, Québec, Canada.