Original ArticleHuman Papillomavirus Genotypes Present in the Oral Mucosa of Newborns and their Concordance with Maternal Cervical Human Papillomavirus Genotypes
Section snippets
Methods
The Finnish HPV Family Study is a longitudinal cohort study conducted at the Department of Obstetrics and Gynecology, Turku University Central Hospital, and the Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland. The study plan was approved by the Research Ethics Committee of Turku University Hospital (#3/1998). A total of 329 pregnant women in their third trimester of pregnancy and, later, their newborns (n = 331; includes 2 sets of twins) were enrolled in the study
Results
HPV was detected in 22.5%, 13.0%, 18.7%, and 16.9% of the oral samples from the whole cohort of newborns at delivery, day 3, month 1, and month 2, respectively. At the third trimester, 16.4% of the cervical samples of the mothers were HPV-DNA positive. The point prevalence of the different HPV genotypes is shown in Figure 1. HPV coinfections were detected more frequently than any single HPV genotype in HPV-positive mothers (45.3%) and were the second most common type of infection in
Discussion
The current study reports the genotype concordance between maternal genital HPV infections and the HPV strain carried by infants during the first 2 months of life. HPV DNA was found in 13.0%-22.5% of all oral samples of the infants during the follow-up period. The previous literature on the prevalence of oral HPV DNA in infants is highly controversial.10 The lowest prevalence (0.9%-2.5%) of oral HPV carriage among infants (from delivery up to 1 year of age) was presented by Smith and colleagues,
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The authors declare no conflicts of interest.