Original ArticleOutcome of Extremely Low Birth Weight Infants Who Received Delivery Room Cardiopulmonary Resuscitation
Section snippets
Methods
The study population included all inborn infants with a birth weight (BW) of 401 to 1000 g and estimated gestational age (GA) of 23 to 30 weeks who were enrolled in the NRN generic database (GDB) from January 1996 to December 2002. During this time, the GDB included inborn and outborn babies <1500 g admitted to a participating center in the first 14 days of life. Infants with congenital anomalies and infants who were not candidates for DR-CPR and who died without receiving resuscitation and
Results
During the study period, 10 476 infants with a BW of 401 to 1000 g and ≥23 and ≤30 weeks estimated GA were treated at 19 participating academic centers. After excluding outborn infants (n = 1209), infants with major congenital anomalies (n = 242), infants who were not candidates for DR-CPR and mechanical ventilation (n = 331), and infants missing data related to chest compressions or medications in the delivery room (n = 9), 8685 infants comprised the study cohort (Figure 1; available at www.jpeds.com
Discussion
Although DR-CPR is a prognostic marker for mortality in ELBW infants, more than half of DR-CPR recipients survived (56%). Unfortunately, DR-CPR survivors had worse short-term complications, such as pneumothorax, severe IVH, and BPD. Infants who survived until the 18- to 22-month follow-up visit had a heavier burden of psychomotor dysfunction, CP, bilateral deafness, and composite NDI compared with infants who did not receive DR-CPR. Only 28% of infants who received DR-CPR were alive and
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Cited by (0)
Supported by the National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, which provided grants for the Neonatal Research Network’s Generic Database Study and Follow-Up Study. The authors declare no conflicts of interest.
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List of National Institute of Child Health and Human Development Neonatal Research Network investigators is available at ww.jpeds.com (Appendix).