Original ArticleEsophageal Impedance in Children: Symptom-Based Results
Section snippets
Methods
Between March 2005 and July 2009, all children who were consecutively referred for an MII-pH investigation because of symptoms suspected to be GER-related were prospectively enrolled. Ethical board and parents approved analysis of data of the investigations that were performed on clinical indication. Patients with overt neurologic, allergic, or metabolic disease, cystic fibrosis, respiratory or gastrointestinal malformations, or acute infections were excluded. Acid suppression (proton pump
Results
Of the 225 subjects included, 70 MII-pH tracings were discarded because of absence of symptoms (n = 30) or artefacts or technical problems (n = 40). Whenever there was an artefact, the impedance was discarded to avoid erroneous evaluations of symptom-reflux associations, even when the tracing was acceptable for clinical interpretation (Figure; available at www.jpeds.com). At least one symptom was associated with a reflux episode in 126 patients (Table I; available at www.jpeds.com). In 29
Discussion
MII-pH is considered to be the most accurate method to detect and characterise GER episodes and provides additional clinical benefit to pH measurement alone.1, 15, 16, 17 In older data, weakly AR is at least as frequent as AR at all ages and more common in young infants, during the postprandial period or during treatment with proton pump inhibitors.2, 6, 7, 9, 18, 19, 20, 21, 22, 23 A clinical advantage of detecting all reflux episodes is to demonstrate a correlation between symptoms and reflux
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Laryngeal signs and pH-multichannel intraluminal impedance in infants and children: The missing ring: LPR and MII-pH in children
2020, Digestive and Liver DiseaseCombined multichannel intraluminal impedance and pH monitoring is helpful in managing children with suspected gastro-oesophageal reflux disease
2018, Digestive and Liver DiseaseCitation Excerpt :This study shows the diagnostic usefulness of MII-pH in infants and children referred by GPs for suspected GORD, as well as its ability in directing therapy and avoiding unnecessary treatment. Previous reports had highlighted the greater sensitivity of MII-pH compared to pH-study only in detecting reflux events [19,20] and in identifying their association to symptoms [21,22], producing a change in managing the patients [23]. Conversely, MII-pH study did not provide a definite parameter profile correlating with the presence of oesophageal mucosa injury [24,25].
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2017, Journal of PediatricsCitation Excerpt :We elected to use the symptom index (SI) as the measure of symptom association to define subgroups in our study. This is consistent with our standard clinical practice and similar to other published pediatric17-19 and adult7,20 studies. The SI was calculated for each patient by dividing the number of reported typical symptoms associated with reflux by the total number of reported symptom events and multiplying by 100.
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2017, Seminars in Nuclear Medicine
Y.P. served as a speaker for Abbott, AstraZeneca, Biogaia, and Mead Johnson Nutritionals and a consultant and speaker for Biocodex, Danone (Nutricia, SHS), Movetis, and Nestle Nutrition. The other authors declare no conflicts of interest.