Original articleInterventions to Reduce Pain during Vaccination in Infancy
Section snippets
Methods
Approval to perform the study was granted by the Ethics Committee of Ankara Training and Research Hospital. The aim, risks, and possible benefits of the study were explained to the mothers, and informed consent was obtained from each.
Results
Demographic and clinical characteristics of the study subjects are summarized in Table I. A total of 243 children were enrolled, of whom 158 were younger than 6 months, 142 (58.4%) were male, and 101 (41.6%) were female. Of the 158 infants under age 6 months, 73 (46%) were breast-fed during vaccination. Crying time and NIPS score were significantly higher in the control group (Table II).
In the infants age 6 to 12 months, crying time and NIPS score were significantly higher in the control group
Discussion
The pain experienced by infants and young children often is underestimated and undertreated.25, 26 This prospective controlled study has demonstrated effective pain reduction during routine vaccination from breast-feeding in infants up to age 6 months and from administration of 12% sucrose solution in children age 6 to 48 months. In the latter group, both sucrose and lidocaine-prilocaine provided better pain reduction than no intervention. The lack of statistical difference between the 2
References (37)
- et al.
Developmental changes in infant pain expression during immunization injections
Soc Sci Med
(1984) - et al.
Making vaccines more acceptable: methods to prevent and minimize pain and other common adverse events associated with vaccines
Vaccine
(2001) - et al.
Comparison of sucrose, expressed breastmilk and breastfeeding on the neonatal responses to heel prick
J Pain
(2001) - et al.
Analgesic effects of breast-feeding or pacifier use with maternal holding in term infants
Ambul Pediatr
(2005) - et al.
Feeding and oral glucose: additive effects on pain reduction in newborns
Early Hum Dev
(2004) - et al.
Lidocaine-prilocaine patch decreases the pain associated with the subcutaneous administration of measles-mumps-rubella vaccine but does not adversely affect the antibody response
J Pediatr
(2000) - et al.
Cross-validation of composite pain scale for preschool children within 24 hours of surgery
Br J Anaesth
(2001) - et al.
Challenge of judging pain in vulnerable infants
Clin Perinatol
(2002) - et al.
Lidocaine-prilocaine patch decreases the pain associated with the subcutaneous administration of measles-mumps-rubella vaccine but does not adversely affect the antibody response
J Pediatr
(2000) - et al.
Use of lidocaine-prilocaine cream for vaccination pain in infants
J Pediatr
(1994)
EMLA cream and oral glucose for immunization pain in 3-month-old infants
Pain
Subcutaneous versus intramuscular injection for booster DT vaccination of adolescents
Vaccine
Active and passive immunization
Children's memory for pain
J Dev Behav Pediatr
Children's expectations and memories of acute distress: the short- and long-term efficacy of pain management interventions
J Pediatr Psychol
Consequences of inadequate analgesia during painful procedures in children
Arch Pediatr Adolesc Med
Breastfeeding is analgesic in healthy newborn
Pediatrics
Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates
BMJ
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The authors declare no funding support or conflicts of interest.