Original articleRespiratory Health in Prematurely Born Preschool Children with and without Bronchopulmonary Dysplasia
Section snippets
Study Groups
Children with a history of BPD, born prematurely between 1998 and 2001 and treated in the neonatal intensive care unit of the Beatrix Children’s Hospital, were invited to participate in this study. BPD was defined as the need for continuous supplemental oxygen at 28 days of age combined with radiographic manifestations. These abnormalities include hyperinflation and nonhomogeneity of pulmonary tissues, with diffuse haziness, or fine or coarser densities extending to the periphery. According to
Participants
Of the 122 eligible prematurely born patients (64 children with BPD and 58 matched prematurely born children without BPD), 77 (63%: 41 BPD and 36 no BPD) agreed to participate in this study (Table I). No differences were found between the (77) participants and (45) “nonparticipants” with regard to gestational age or birth weight. From the nonparticipants, 8 children had moved, 1 child was not able to participate because of a tracheotomy, 5 parents refused to give permission, and 31 parents did
Discussion
Premature birth, particularly when complicated by the subsequent development of BPD, has been associated with respiratory morbidity in early childhood. This study shows that children with BPD do not report having more respiratory symptoms, but they do have lung function abnormalities (i.e. a lower mean reactance and a higher resonance frequency), indicating decreased compliance, compared with premature children without BPD. Another important finding is that FOT is able to discriminate between
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Supported by Startersgrant Beatrix Children’s Hospital.