Original articleMixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus
Section snippets
Participants
On the basis of the short-term data reported by Kaplan et al, several providers in our diabetes clinic told their patients they could start mixing IG and RAI in the same syringe. The children and adolescents in this study were observed prospectively by their diabetes care provider. Their medical records were reviewed retrospectively to assess any difference in glycemic control when IG was mixed in the same syringe with a RAI analogue (aspart or lispro) compared with when it was taken in a
Results
The 2 groups were equivalent at baseline in age, duration of T1D, and HbA1c . Data were available for all patients at 3 months follow-up. Ninety-three patients completed the study at 6 months (mix group n = 44; control group n = 49). At 3 and 6 months follow-up, the percentage of SMBG values in, above, and below the target range did not vary significantly between or within the control and mix groups (all P = not significant, data not shown). Likewise, there were no significant differences in
Discussion
These results indicate that there is no significant difference in glycemic control between children and adolescents who mix IG in the same syringe with a RAI analogue and those who take IG as a separate injection. The findings are especially encouraging to those patients who wish to minimize the number of total daily injections because of needle fear, forgetting injections, or other injection-related issues. The ability to mix IG in the same syringe with a RAI analogue presents the possibility
References (8)
- et al.
Improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning, evening, or split dose insulin glargine
Diabetes Res Clin Pr
(2004) - et al.
Reduced hypoglycemic episodes and improved glycemic control in children with type 1 diabetes using insulin glargine and neutral protamine hagedorn insulin
J Pediatr
(2003) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus
N Engl J Med
(1993)- et al.
Insulin glargine, an updated review of its use in the management of diabetes mellitus
Drugs
(2003)
Cited by (30)
Insulin aspart in the pediatric population
2012, Avances en DiabetologiaManagement of Diabetes Mellitus in Children
2010, Endocrinology: Adult and Pediatric, Sixth EditionUpdate on new insulins
2009, Anales de PediatriaInsulin treatment in children and adolescents with diabetes
2014, Pediatric Diabetes
Supported by a grant (M01 RR00069) from the General Clinical Research Centers Program, National Centers for Research Resources, National Institutes of Health.