ReviewDrug-induced liver injury: Interactions between drug properties and host factors
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open access
Abbreviations
DILI
drug-induced liver injury
HLA
human leucocyte antigen
DAMPs
the damage associated molecular pattern molecules
ADMET
absorption, distribution, metabolism, excretion and toxicity
GST
glutathione-S-transferase
ROS
reactive oxygen species
JNK
c-Jun N-terminal kinase
Nrf-2
nuclear factor erythroid 2-related factor 2
Keap-1
Kelch-like ECH-associated protein 1
mtDNA
mitochondrial DNA
MPT
mitochondrial permeability transition
BSEP
bile salt export pump
ATP
adenosine triphosphate
P-gp
P-glycoprotein
MRP
multidrug resistance-associated protein
NAT2
N-acetyltransferase 2
CYP450
cytochrome P450
GSTM1
glutathione S-transferase Mu 1
GSTT1
glutathione S-transferase theta 1
NSAIDs
non-steroidal anti-inflammatory drugs
GSH
gluthatione
POLG
polymerase (DNA directed), gamma
FXR
farnesoid X receptor
LPS
lipopolysaccharides
MELD
Model for end-stage liver disease
PARP-1
Poly-(ADP-Ribose) Polymerase-1
NAFLD
non-alcoholic fatty liver disease
SOD2
superoxide dismutase 2
GPX1
glutathione peroxidase
NASH
nonalcoholic steatohepatitis
UDPGT
UDP-glucuronosyltransferase
NRTIs
nucleoside reverse transcriptase Inhibitors
PPARγ
peroxisome proliferator-activated receptor gamma
APC
antigen-presenting cell
MHC
major histocompatibility complex
Keywords
Drug-induced liver injury
Drug physicochemical properties
Host factors
Drug-host Interaction
Pharmacogenetics
Drug metabolism
Drug clearance
Clinical toxicology
Cited by (0)
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These authors equally contributed to the manuscript.
© 2015 European Association for the Study of the Liver. Published by Elsevier B.V.