Rhinitis, sinusitis, and upper airway diseaseEvolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life
Section snippets
Study design and population
The MAS, a prospective birth cohort study, recruited a selection of 1314 of 7609 infants born in 1990 on 6 delivery wards in 5 German cities (Berlin, Dusseldorf, Mainz, Freiburg, and Munich).25 The study was approved by local ethics committees. Each parent provided written informed consent at the time of enrollment. All children were followed up at ages 1, 3, 6, 12, 18, and 24 months and then yearly from the age of 3 to 13 years and then at 20 years of age. In this analysis we included subjects
Study population
Overall, 722 of the 1314 subjects recruited in the MAS cohort met the inclusion criteria (see Fig E1 in this article's Online Repository at www.jacionline.org) for this study. We found no difference in parental history of hay fever, number of older siblings, and asthma person-year rates between subjects included and excluded from the study. By contrast, German nationality, higher parental education, longer breast-feeding, mother's nonsmoking status during pregnancy, and MAR were more common in
Discussion
Our study is the first to analyze the evolution of the IgE response to a comprehensive panel of 12 HDM allergens in a longitudinal manner during the first 2 decades of life. In more than 700 German participants followed from birth to age 20 years (the MAS birth cohort study), we found that IgE sensitization to individual HDM allergens increases in prevalence and breadth regarding the number of recognized allergen molecules during the first decade of life. During the first decade of life, the
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Cited by (0)
Supported by the Deutsche Forschungsgemeinschaft (DFG) MA-4740/1-1, in part by grants F4602 and F4605 of the Austrian Science Fund (FWF), and by the Christian Doppler Research Association, Vienna, Austria. The Multicenter Allergy Study was funded by grants from the German Federal Ministry of Education and Research (07015633, 07 ALE 27, 01EE9405/5, and 01EE9406) and the German Research Foundation (KE 1462/2-1). D.P. received a DAAD scholarship. O.T. received a Clemens von Pirquet Foundation scholarship.
Disclosure of potential conflict of interest: C. Lupinek receives payment for lectures form Thermo Fisher Scientific and travel support from the American Academy of Allergy, Asthma & Immunology (AAAAI). R. Valenta receives research support from Austrian Science Fund FWF, Biomay AG, Thermo Fisher Scientific, and Christian Doppler Research Association; serves as a consultant for Biomay AG, Thermo Fisher Scientific, and Fresenius Medical Care; and receives payment for lectures from Thermo Fisher Scientific. P. M. Matricardi serves as a consultant for Thermo Fisher Scientific, HYCOR biomedical, and Euroimmun AG and receives grant support from Thermo Fisher Scientific. The rest of the authors declare that they have no relevant conflicts of interest.