Registry of the International Society for Heart and Lung Transplantation: Twentieth Pediatric Lung and Heart-Lung Transplantation Report—2017; Focus Theme: Allograft ischemic time
Section snippets
Data collection, conventions, and statistical methods
National and multinational organ/data exchange organizations and individual centers submit data to the ISHLT Registry. Since the Registry’s inception, 472 heart transplant centers, 256 lung transplant centers, and 180 heart-lung transplant centers have reported data to the Registry. We estimate data submitted to the Registry represents approximately 75% of worldwide transplant activity.
An overview of donor and recipient characteristics and outcomes is presented throughout the report. The data
Focus Theme Methods: Allograft ischemic time
The Registry Steering Committee selected allograft ischemic time as the theme topic for the 2017 report. Lung allograft ischemic time was defined as the time that elapsed between aortic cross-clamp performed during organ procurement surgery and lung allograft reperfusion during lung transplant surgery. For double lung transplant, the reperfusion of the second lung was used for allograft ischemic time calculation. Heart-lung allograft ischemic time was defined as the time that elapsed between
Volume, age distribution, indications, and donor characteristics
The Registry contains data for 2,330 pediatric lung and 730 pediatric heart-lung transplants performed through June 30, 2016. In 2015, the last complete year included in this year’s Registry Report, the number of pediatric lung transplants was 96, which is consistent with the range of 90 to 137 observed during the past 12 years (Figure 1).
Similar to previous years,1, 2 most of the lung transplants reported for 2015 were performed in older children (aged 11–17 years), with 61% of children who
Volume, age distribution, indications, and survival
The number of reported pediatric heart-lung transplant procedures continues to remain low compared with the early 1990s. During the past 9 years, an average of 9 procedures have been reported per year. Since 2008, all procedures occurred in children and adolescents, with no procedures performed in the infant age group (Figure 17). Historically most heart-lung transplants have occurred in the group aged 11 to 17 years (eSlide HL(p) 4). Retransplantation is rarely performed, with only 2 reported
Focus theme: Allograft ischemic times
The aim of this focus theme was to examine factors associated with allograft ischemic time and to assess the association of allograft ischemic time with outcomes. We stratified the study group by allograft ischemic times duration of < 2 hours, 2 to < 4 hours, 4 to < 6 hours, and ≥6 hours. Distributions of allograft ischemic time based on diagnosis and age were similar and are reported in eSlide L(p) 92 and 93. No considerable changes occurred in allograft ischemic time during the past 25 years,
Disclosure statement
DC received travel support from Astellas Pharma, Inc. and serves as a consultant and speaker for Roche Ltd. L.H.L. received research grant support to his institution from Novartis Inc. and Abbott Inc. J.W.R. and J.S., serve as consultants for Medtronic, Inc. None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.
References (3)
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The Registry of the International Society for Heart and Lung Transplantation: nineteenth pediatric lung and heart-lung transplantation report—2016; focus theme: primary diagnostic indications for transplant
J Heart Lung Transplant
(2016)
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