Original article—alimentary tractA Shift in the Clinical Spectrum of Eosinophilic Gastroenteritis Toward the Mucosal Disease Type
Section snippets
Methods
Our previous experience with eosinophilic gastroenteritis from 1950 through 1986 was reported in 1990 and included 40 subjects.7 The present study was approved by the Mayo Foundation Institutional Review Board.
Results
A total of 59 patients with eosinophilic gastroenteritis were identified: 52 with disease of the mucosa, 3 with disease of the muscle layer, and 4 with subserosal involvement. Eleven patients were identified with unexplained peripheral eosinophilia and gastrointestinal symptoms. Table 1 summarizes the sociodemographic findings for the EG and PEos groups. The mean age at presentation was 47 years for EG and 37 years for PEos patients. Among those with EG, 61% were male, 98% were Caucasian with 1
Discussion
The present study reports our clinical experience with adult EG. A total of 59 patients with EG were seen in our center over the past 20 years and, when combined with our previous experience, a total of 99 patients with EG were seen over a 50-year period. The data suggest that unlike other eosinophilic GI disorders such as eosinophilic esophagitis, EG remains a rare disorder with an average of only 2 to 3 cases diagnosed annually at a large tertiary referral center. This study evaluated
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2021, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :The exact etiology of eosinophilic gastrointestinal diseases (EGIDs) remain unknown.[3,5] Because EGE presents in a non-specific manner, with commonly reported symptoms including abdominal pain, nausea, and vomiting, diagnosis can be challenging.[6–12] Some clinical features that may increase suspicion include history of atopic disease, peripheral eosinophilia, hypoalbuminemia, and elevated serum IgE level, which have been reported to be associated with EGIDs in several series.[5, 8–10,12,13]
Conflicts of interest The authors disclose no conflicts.
This article has an accompanying continuing medical education activity on page e88. Learning Objectives—At the end of this activity, the learner should be able to understand the clinical spectrum and clinical presentation of eosinophilic gastroenteritis and understand the imaging and pathological features of eosinophilic gastroenteritis.