Human enterovirus and parechovirus infections in newborns with sepsis-like illness and neurological disorders
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Enterovirus meningitis in Mayotte French Comoros Island, March-June 2019
2022, Journal of Clinical VirologyCitation Excerpt :Only one PeV meningitis was diagnosed in a neonate. PeV infection are more frequently described in young infants [4,20], in our study the proportion of children under 3 months of age was 44% (54/122). PeV screening is thus recommended for infants under 1 year old presenting with sepsis-like disease or suspected meningitis.
Emerging Non-Polio Enteroviruses recognized in the framework of the Acute Flaccid Paralyses (AFP) surveillance system in Northern Italy, 2016–2018
2021, International Journal of Infectious DiseasesCitation Excerpt :This observation was also supported from the sequence analyses of NEPVs identified in 2018; in fact, EV-D68 identified in this study belonged to the B2 sub-clade, sharing high similarity with the US strains (Morens et al., 2019), and E-30 had a nucleotide identity of 98.2–100% with sequences belonging to group G1 that have been circulating in Europe since 2016 and dominating in 2018 (Broberg et al., 2018). To date, no systematic NPEV hospital- and community-based surveillance systems are set up in Italy; thus, information on NPEV circulation is derived exclusively from observational studies, especially among children affected by severe conditions (Parisi et al., 2016; Piralla et al., 2014; Piralla et al., 2020). Nevertheless, with the emergence of several NPEVs - in particular EV-D68, EV-A71, and E-30 - involved in severe neurological manifestations (Bubba et al., 2020), AFPS has demonstrated renewed strength in continuing to provide epidemiological evidence to assist public health efforts (Kim et al., 2014; Suresh et al., 2018; Bubba et al., 2020; Roberts et al., 2020).
Neurological and neurodevelopmental outcomes after human parechovirus CNS infection in neonates and young children: a systematic review and meta-analysis
2020, The Lancet Child and Adolescent HealthCitation Excerpt :This theory is supported by seven studies in this Article, which included infants who were born preterm;6,7,79,80,86,93,94 others did not specify the gestational ages of included children.17,81,83,84,87,89,90,92 Neonates and young children not only often have the highest burden of parechovirus infection of the CNS, but they also have the most severe clinical manifestations often resulting in intensive care unit hospitalisation and the poorest outcomes.6–9,11–15,17,79,80,86–88,93,94 In addition to age-related vulnerability of the developing white matter for ischaemic and inflammatory damage,11,97 other factors thought to play a part in the vulnerability of neonates and young children to parechovirus infection of the CNS are their immature immune system and insufficient protective maternal antibodies.98
Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants
2020, Journal of Clinical VirologyHuman parechovirus type 5 neurological infection in a neonate with a favourable outcome: A case report
2019, International Journal of Infectious DiseasesEnteroviral infection in neonates
2019, Journal of Microbiology, Immunology and Infection