TY - JOUR T1 - Incidence and factors associated with invasive candidiasis in a neonatal intensive care unit in Mexico JO - Anales de Pediatría (English Edition) T2 - AU - Lona-Reyes,Juan C. AU - Gómez-Ruiz,Larissa M. AU - Cordero-Zamora,Araceli AU - Cortés-González,Sandra I. AU - Quiles-Corona,Moisés AU - Pérez-Ramírez,Rene O. AU - Pinto-Macedo,Herlinda SN - 23412879 M3 - 10.1016/j.anpede.2021.07.008 DO - 10.1016/j.anpede.2021.07.008 UR - https://analesdepediatria.org/en-incidence-factors-associated-with-invasive-articulo-S2341287922001405 AB - IntroductionNeonatal Candida spp. infections are serious events due to their morbidity and mortality, however, epidemiological information is insufficient in developing countries. The objective of this study was to describe the incidence and factors associated with invasive infection by Candida spp. in a Neonatal Intensive Care Unit in Mexico. MethodsCase-control study nested in a cohort and matched for birth weight. We estimated the incidence of invasive neonatal infection by Candida spp. For the bivariate analysis of the studied factors, McNemar's test was used to contrast hypotheses and multivariate analysis was made with logistic regression. ResultsThe incidence of infection was 2.27 events/1000 live newborns. The species identified were C. albicans 35.3% (n 30), C. parapsilosis 30.6% (n 26), C. glabrata 31.8% (n 27) and two events with C. lipolytica. The factors associated with a higher risk were mechanical ventilation (OR 3.04, 95% CI 1.13–8.14), systemic antibiotics (OR 7.48, 95% CI 1.30–42.9), number of antimicrobial regimens (OR 2.02, 95% CI 1.01–4.03), and days with total parenteral nutrition (OR 1.14, 95% CI 1.04–1.25) or with venous catheter central (OR 1.11, 95% CI 1.02–1.20). Fluconazole prophylaxis decreased the risk (OR 0.32, 95% CI 0.12−0.84). ConclusionsInvasive interventions (central catheter, mechanical ventilation, and parenteral nutrition) and the use of antimicrobials increase the risk of neonatal Candida spp. Infection, while prophylactic fluconazole is protective. ER -