TY - JOUR T1 - Characteristics of patients with invasive pneumococcal disease requiring admission to intensive care units JO - Anales de Pediatría (English Edition) T2 - AU - Díaz-Conradi,Alvaro AU - García-García,Juan José AU - González Peris,Sebastià AU - Fernández de Sevilla,Mariona AU - Moraga Llop,Fernando AU - Ventura,Paula Sol AU - Domínguez,Angela SN - 23412879 M3 - 10.1016/j.anpede.2020.03.008 DO - 10.1016/j.anpede.2020.03.008 UR - https://analesdepediatria.org/en-characteristics-patients-with-invasive-pneumococcal-articulo-S2341287920302131 AB - IntroductionPatients with invasive pneumococcal disease (IPD) may require admission into paediatric intensive care units (PICU). The aim of this study is to analyse the epidemiological, clinical, and microbiological characteristics associated with IPD that may require admission to the PICU. Material and methodsA prospective study was conducted on cases of IPD diagnosed in three Paediatric Hospitals in Barcelona between January 2012 and June 2016. An analysis was made of the associations between the admission to PICU and the epidemiological, clinical, and microbiological variables. ResultsA total of 263 cases with IPD were included, of which 19% (n=50) required admission to PICU. Patients with septic shock (7; 100%), meningitis (16; 84.2%), and those with complicated pneumonia (23; 15.2%) were admitted to the PICU. The most frequent complications were pulmonary (35.2%) and neurological (39.5%). The ratio between admission and non-admission to PICU was 4.7 times higher in subjects with an underlying disease. The serotypes associated with PICU admission were 19A (23% of the total of this serotype), serotype 14 (20%), serotype 3 (17%), and serotype 1 (12.5%). ConclusionsIPD required PICU admission in cases of septic shock and meningitis, and less so with complicated pneumonia. The percentage of admissions is greater in children with an underlying disease. Admission into the PICU involves a longer stay, complications during the acute phase, as well as sequelae, particularly neurological ones. The serotypes of the patients that were admitted to PICU were predominantly vaccine serotypes. ER -