TY - JOUR T1 - Early hypophosphataemia in at risk newborns. Frequency and magnitude JO - Anales de Pediatría (English Edition) T2 - AU - Bustos Lozano,Gerardo AU - Hidalgo Romero,Álvaro AU - Melgar Bonis,Ana AU - Ureta Velasco,Noelia AU - Orbea Gallardo,Carlos AU - Pallás Alonso,Carmen SN - 23412879 M3 - 10.1016/j.anpede.2017.04.009 DO - 10.1016/j.anpede.2017.04.009 UR - https://analesdepediatria.org/en-early-hypophosphataemia-in-at-risk-articulo-S2341287918300255 AB - ObjectiveTo determine the frequency and magnitude of neonatal hypophosphataemia (<4mg/dL) in a neonatal Intensive Care Unit and to describe risk groups. Patients and methodsRetrospective study of hospitalised newborns over a 44 month period (phase 1). Retrospective study of <1500g/<32 weeks of gestation newborns over a 6 month period (phase 2). Prospective study of <1500g or 1550–2000g, and intrauterine growth restriction (IUGR) newborns. Measurements were made on the 1st, 3rd, 7th, and 14th days of life (phase 3). ResultsPhase 1: 34 (2.4%) of 1,394 patients had a diagnosis of hypophosphataemia, 76% of them ≤32 weeks of gestation and <1500g, and 24% >32 weeks with weightmg/dL in 5 (6.8%). Eight (75%) of those with hypophosphataemia had IUGR, and 4 (25%) weighed <1000g. Five cases had associated hypokalaemia, and three hypercalcaemia. Phase 3: 9 (45%) of 20 patients had hypophosphataemia, all of them <1000g or <1200g and weight percentile <10. Thirty-three percent of samples on days 1, 3, and 7 showed hypophosphataemia, four of them <2mg/dL. There was mild hypokalaemia in 5 (55%), and mild hypercalcaemia in 2 (22%) cases. Hypophosphataemia was associated with lower enteral nutrition and higher parenteral amino acid intake in the early days of life. ConclusionsHypophosphataemia is common, and can be severe, in the first week of life in premature infants <1000g, and newborns <1200g with foetal malnutrition and receiving amino acids in early parenteral nutrition. ER -