TY - JOUR T1 - Evaluation of sensitization to Der p 1 and Der p 2 in a pediatric population of the North of Portugal JO - Anales de Pediatría (English Edition) T2 - AU - Peixoto,Sara AU - Soares,Joana AU - Monteiro,Tânia AU - Carvalho,Marisa AU - Santos,Marinela AU - Simões,Carla AU - Quaresma,Márcia SN - 23412879 M3 - 10.1016/j.anpede.2018.01.002 DO - 10.1016/j.anpede.2018.01.002 UR - https://analesdepediatria.org/en-evaluation-sensitization-der-p-1-articulo-S2341287918300115 AB - IntroductionIn Portugal, data on the role of Der p 1 and Der p 2 in patients with house dust mite (HDM) allergy are scarce. Allergen-specific immunotherapy (sIT) is the only treatment that improves symptoms, reduces the need for pharmacological therapy and modifies the natural history of the disease. With this study, the authors aim to understand the local epidemiology and to clarify if the molecular assay of major allergens is advantageous in deciding and/or modifying the decision to initiate sIT in children with clinical indication which are sensitized to Dermatophagoides pteronyssinus. MethodsRetrospective study with analysis of patients with asthma and/or rhinitis. Study period: January/2013–December/2016. Inclusion criteria: 1) positive prick-test to D. pteronyssinus; and 2) clinically relevant disease under treatment. Assay Der p 1 and Der p 2 values ≥0.35kUA/L were considered positive. Statistical significance was set at p<0.05. ResultsThe clinical files of 279 patients. Mean ages 9.55 years (min. 4–max. 17). Asthma was present in 199 children (71.3%) and rhinitis in 245 (87.8%). Der p 1 and Der p 2 was <0.35kUA/L in 29 (10.4%) patients. The value of Der p 1/Der p 2 correlated with the size of the prick-test papule, the value of the eosinophils and the total IgE. ConclusionsDer p 1 and Der p 2 are dominant allergens in our population and there may be benefits in determining these molecular allergen levels in patients with a positive prick-test and a clinical indication for sIT prior to a decision of initiating sIT or not. ER -