TY - JOUR T1 - Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain JO - Anales de Pediatría (English Edition) T2 - AU - Martín del Valle,Fernando AU - Calvo,Cristina AU - Martinez-Rienda,Inés AU - Cilla,Amaia AU - Romero,María P. AU - Menasalvas,Ana Isabel AU - Reis-Iglesias,Leticia AU - Roda,Diana AU - Pena,María J. AU - Rabella,Nuria AU - Portugués de la Red,María del Mar AU - Megías,Gregoria AU - Moreno-Docón,Antonio AU - Otero,Almudena AU - Cabrerizo,María SN - 23412879 M3 - 10.1016/j.anpede.2017.02.010 DO - 10.1016/j.anpede.2017.02.010 UR - https://analesdepediatria.org/en-epidemiological-clinical-characteristics-infants-admitted-articulo-S2341287917302156 AB - IntroductionHuman parechovirus (HPeV) is one of the recently described picornaviridae viruses that have been associated with fever without source (FWS), clinical sepsis, gastroenteritis, meningitis, or encephalitis in very young infants. The aim of this study is to describe the epidemiology and clinical features of these viruses. Patients and methodsA prospective multicentre 3-year study was conducted in 12 hospitals in Spain. Out of 850 specimens examined, 47 were positive (5.52%), with HPeV-3 being the most frequent (29 cases). Infections occurred throughout the year, but mainly in May and July, and a biennial distribution was observed. More than half (57%) were neonates, and only 2 children were older than 3 months. Fever was present in all children, with irritability in 45%, rash in 18.6%, and diarrhoea in 14%. The results of biochemical tests were all in normal range. The most common final diagnosis was FWS (61%), followed by clinical sepsis (29%). Up to 29% of infants were admitted to the intensive care unit, but only one patient had sequelae. ResultsOut of 850 specimens examined, 47 were positive (5.52%) for HPeV, with HPeV-3 being the most frequent (29 cases). Infections occurred throughout the year, but mainly in May and July, and a biennial distribution was observed. More than half (57%) were neonates, and only 2 children were older than 3 months. Fever was present in all children, with irritability in 45%, rash in 18.6%, and diarrhoea in 14%. The results of biochemical tests were all in normal range. The most common final diagnosis was FWS (61%), followed by clinical sepsis (29%). Up to 29% of infants were admitted to the intensive care unit, but only one patient had sequelae. ConclusionsHPeV circulates in our country, mainly during spring and summer, and affects young infants with a FWS and clinical sepsis. Molecular diagnostic techniques in all hospitals could help in improving the management of patients with these infections. ER -