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A scoping review of methods of measuring smartphone usage

Revisión de alcance de las herramientas de medición de uso de teléfonos inteligentes
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Carmen Cendrero-Luengoa,b, Sonia de Paz-Cantosb,c, Adrián González-Marrónb,c, Cristina Lidón-Moyanob,c, Ana Díez-Izquierdob,d, José M. Martínez-Sáncheza,c,
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jmmartinezs@unex.es

Corresponding author.
a Grupo de Evaluación de Determinantes de la Salud y Políticas Sanitarias, Universidad de Extremadura, Mérida, Badajoz, Spain
b Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain
c Grupo de Evaluación de Determinantes de Salud y Políticas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Vallés, Barcelona, Spain
d Sección de Neumología y Alergología Pediátricas, Servicio de Pediatría, Hospital Universitari Vall d’Hebron, Barcelona, Spain
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Table 1. Characteristics of the 89 studies that assessed screen time with questionnaires*.
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Table 2. Characteristics of studies and instruments used to measure smartphone screen time in the pediatric population.
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Abstract
Introduction

Screen usage patterns have shifted significantly in recent years, with a notable increase in the use of internet-enabled smartphones among children and adolescents.

Objective

The aim of this scoping review was to describe the measurement tools used to estimate smartphone screen time in individuals aged less than 18 years.

Methods

We conducted a systematic search in MEDLINE Complete (via PubMed) and ScienceDirect for studies published between May 2014 and May 2024. A total of 89 population-based surveillance studies were included for analysis.

Results

The most common assessment method was the use of non-validated self-report questionnaires completed by parents. Only seven studies used a validated instrument, and in six of these cases, the tool was not specifically designed to measure screen time. Only one study applied a validated scale developed expressly for this purpose: the Screen Time Questionnaire (STQ).

Conclusion

The heterogeneity of current findings on smartphone usage time among minors is evident. There is a clear need for a standardized questionnaire to accurately measure this variable and to support the development of evidence-based guidelines and recommendations.

Keywords:
Child health
Media use
Mobile phone use
Public health
Screen time
Surveys and questionnaires
Resumen
Introducción

Los patrones de uso de pantallas han cambiado de manera significativa en los últimos años, con un aumento notable en el uso de teléfonos inteligentes con acceso a internet entre niños y adolescentes.

Objetivo

El objetivo de esta revisión de alcance es describir las herramientas de medición utilizadas para estimar el tiempo de uso de pantallas en teléfonos inteligentes en individuos menores de 18 años.

Métodos

Se realizó una búsqueda sistemática en MEDLINE Complete (a través de PubMed) y ScienceDirect para estudios publicados entre mayo de 2014 y mayo de 2024. En total, se incluyeron 89 estudios de vigilancia poblacional para el análisis.

Resultados

El método de evaluación más común fue el uso de cuestionarios de autorreporte no validados, completados por los padres. Solo siete estudios emplearon un instrumento validado y, en seis de estos casos, la herramienta no fue diseñada específicamente para medir el tiempo de pantalla. Únicamente un estudio aplicó una escala validada desarrollada expresamente para este fin: el Screen Time Questionnaire (STQ).

Conclusión

La heterogeneidad de los hallazgos existentes sobre el tiempo de uso de teléfonos inteligentes en menores es evidente. Existe una clara necesidad de desarrollar un cuestionario estandarizado que permita medir esta variable con precisión y apoyar la creación de guías y recomendaciones basadas en evidencia.

Palabras clave:
Salud infantil
Uso de medios
Uso de teléfono móvil
Salud pública
Tiempo de pantalla
Encuestas y cuestionarios
Graphical abstract
Full Text
Introduction

New generations live with electronic devices and media as a central part of their daily lives.1,2 Today, usage patterns have evolved, and smartphones have become the most widely used devices for digital consumption across all age groups and are now ubiquitous in modern society.3,4 Smartphones provide immediate access to a vast range of applications, content, and services.3–5 Device ownership is occurring at increasingly younger ages, and due to the limited current understanding of the effects of these devices, many parents may not fully grasp the potential repercussions of their children’s use.3,4 Thus, the features of these devices and their widespread acceptance by families have contributed to a rise in screen time in the pediatric population worldwide.3,4 Limited parental supervision, combined with exposure to inappropriate or potentially harmful content—sometimes influenced by specific digital platforms—can increase the risks associated with smartphone use and contribute to an unsafe environment for children and adolescents.7

It is difficult to find a balance in this area, although it all depends on the variables and populations of interest, and it is an active research topic and a subject of considerable public and scientific debate.1,3,5,8 There is controversy about the possible effects and patterns of screen use in children and adolescents.8,9 Although some beneficial effects of interactive screen time have been identified, excessive use has been associated with negative impacts on the physical, behavioral, and cognitive development of young people.10 Excessive screen time may interfere with a child’s learning opportunities and overall development, potentially emerging as a new determinant of health that warrants further investigation in the pediatric population.11

Many children and adolescents in developed countries exceed recommended screen time limits, and social media, audiovisual platforms, and games are the contents consumed most frequently, often at the expense of time spent on face-to-face interactions.1,2,6,12 As mobile screen exposure is increasingly seen as an addictive activity, with the pediatric population being particularly vulnerable, organizations such as the Spanish Association of Pediatrics (SAP), the American Academy of Pediatrics (AAP), and the World Health Organization (WHO), among others, have issued reports with recommendations for appropriate global screen time limits.8,9,13 However, it is important to note that most of the scientific evidence on which these recommendations are based concerns television watching.8,9,13

For scientific advances to be relevant to society and applicable to public health policy, the correct assessment of health determinants in relation to screen time is necessary to establish effective surveillance, oversight and evaluation systems to monitor and reduce the impact on the health of the population of possible future addictive behaviors.14 While new measurement trends, such as mobile applications and tracking tools, are emerging, the methodology is still inconsistent and the analysis of screen time continues to be a secondary concern.15

Research in this area is growing; however, to date, no review has been published that all the recent literature on how screen time is measured in cross-sectional studies in children aged less than 18 years. Therefore, we performed a scoping review with the aim of describing the measurement tools used to assess smartphone screen time in children aged less than 18 years in cross-sectional studies.

Methods

The reporting in this review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) method.16

We conducted a scoping review to systematically detail the available scientific evidence on the measurement instruments used to assess the variable “smartphone screen time” in children and youth. The following research question was formulated:

“What measurement methods are utilized to assess smartphone screen time among children and adolescents aged less than 18 years?”.

Eligibility criteria

For this review, specific inclusion and exclusion criteria were established to ensure the selection of relevant studies. Studies were included if they assessed smartphone screen time in children and adolescents aged less than 18 years, had a cross-sectional design, were published between May 2014 and May 2024, and were available in English, Spanish, French, or Italian. We included all studies whose primary objective was to assess smartphone use in children aged less than 18 years that specifically reported the time they spent using these devices. We excluded any articles that did not directly measure smartphone screen time, were conducted in individuals aged more than 18 years, or that were reviews, editorials, letters to the editor, or case reports. We also excluded studies that did not provide sufficient information regarding the measurement methods employed.

Information sources

The following databases were searched to identify all relevant literature: MEDLINE Complete among PubMed and Science direct, filtering for articles published between May 2014 and May 2024.

Search

After filtering with different possible search terms, we selected the following terms because others did not yield sufficient results and/or retrieved articles that did not fit the objective of the review.

The search terms used for this review included “screen time”, “children*, “adolescent*”, “pediatric*”, “infant*”, “preschool*”, “prevalence” OR “cross-sectional”, “smartphone”, “mobile phone”, “cell” combining all of them and selecting the search that yielded the most papers.

Selection of sources of evidence

RefWorks was used to store information on the selected studies. The title and abstracts of all articles obtained during the initial broad search were reviewed independently by two reviewers (CCL and JMMS) to identify potential eligible studies. Two reviewers (CCL and JMMS) independently extracted and assessed full-text articles that were considered candidates for further analysis based on predefined eligibility criteria.

Two investigators (CCL and JMMS) independently extracted and reported data on the following aspects of each study using standardized forms: study design; year of publication; description of study population; measurement of smartphone screen time; and study outcomes. Any differences of opinion were resolved through group meetings between all reviewers to reach consensus. Fig. 1 shows the flow diagram of the study selection process (adapted from PRISMA).

Figure 1.

The following patches are recommended to bring the diagram closer to the PRISMA format.

Finally, we divided the review in two sections according to the different characteristics of the sources: (1) articles measuring only smartphone screen time (n = 14); (2) articles measuring screen time for smartphones and other devices (n = 75). The variables for which we retrieved data for each of these sections were: (1) Articles measuring only smartphone screen time: first author and year of publication, study objective, study design, measuring instrument, validation of questionnaire, item measuring smartphone usage, answer options, respondent, and main outcome concerning smartphone screen time. (2) Articles measuring screen time for smartphones and other devices: first author and year of publication, study objective, study design, measuring instrument, validation of questionnaire, item measuring screen time for smartphones and other devices, answer options, respondent, types of screen studied and main outcome concerning smartphone screen time (Supplementary Table).

Results

A total of 321 potentially relevant articles were identified. After reading the titles and abstracts and removing duplicates, a total of 146 full text articles were assessed for eligibility; of these, 57 articles were excluded for the following reasons: not original articles (review, non-scientific articles or not in included languages) (n = 31); reporting parental smartphone screen time (n = 8); studying other devices, not measuring smartphone screen time (n = 18) (Fig. 1). Of the 89 included studies, seven used standardized questionnaires, of which only one had been designed for the primary purpose of assessing smartphone screen time.

Table 1 presents the main characteristics of the 89 studies. The target population varied. Most studies included more than one age group (34.8%), and adolescents were the most studied age group (28.1%). The sample size was also heterogeneous. More than a third of the articles (37.1%) were conducted in samples greater than 500. The continent with the most published articles was Asia (40.4%), followed by Europe (34.8%), America (21.4%) and, lastly, Oceania (2.2%). Almost all studies (82%) used self-report questionnaires to assess screen time. The questionnaire was completed by the child in almost half of the articles (48.3%). When it came to the reporting of the screen time variable, more than half of the researchers expressed the results in hours per day (53.9%). The questionnaires used were not validated in 90.1% of the included articles. Only 15.7% of the articles measured smartphone screen time alone, the rest (84.3%) included smartphone and other devices. In addition, 95.5% of the studies did not document the first or last use of the day. Most of the studies were published before 2020 (79.8%).

Table 1.

Characteristics of the 89 studies that assessed screen time with questionnaires*.

  n (%) 
Target populationa   
Preschoolers  22 (24.7) 
School-aged children  11 (12.4) 
Adolescents  25 (28.1) 
Different age groups  31 (34.8) 
Sample sizea   
<500  33 (37.1) 
500−1000  22 (24.7) 
>1000  34 (38.2) 
Geographical area   
Asia  36 (40.4) 
Africa 
America  19 (21.4) 
Europa  31 (34.8) 
Oceania  2 (2.2) 
More than one  1 (1.1) 
Questionnaire administration   
Face-to-face  2 (2.2) 
Self-administered  73 (82.0) 
Online  11 (12.4) 
Telephone  1 (1.1) 
More than one  2 (2.2) 
Respondent   
Children/Adolescent  43 (48.3) 
Parents or guardian  38 (42.7) 
Both  8 (8.9) 
Reporting of screen time variable   
Hours/day  48 (53.9) 
Hours/week  3 (3.4) 
Hours/weekday-Hours/weekend day  4 (4.5) 
Hours/device  1 (1.1) 
No screentime data  33 (37) 
Validated screen time questionnaire   
Yes  8 (8.9) 
No  81 (90.1) 
Studied devices   
Only smartphone  14 (15.7) 
Smartphone and other devices  75 (84.3) 
Reported first/last use   
Yes  4 (4.5) 
No  85 (95.5) 
Year published   
<2020  70 (78.6) 
>2021  19 (21.3) 
a

Not available for all studies.

*

Search conducted in 2024.

Table 2 presents a summary of the studies who focused exclusively on smartphone screen time. Most of the articles included in this section measured smartphone screentime by means of self-report questionnaires that had not been validated.17–26

Table 2.

Characteristics of studies and instruments used to measure smartphone screen time in the pediatric population.

Author, publication year (ref)  Main objective  Study design  Measuring instrument  Validated questionnaire  Item measuring smartphone usage  Answer options  Respondent/data source 
Ryu, 2022 17  To evaluate the association between usage patterns and dietary risk factors  Cross-sectional study  Self-administered questionnaire  No  Questionnaire not reported nor published by authors  Questionnaire not reported nor published by the authors  Child 
Song, 2022 18  To investigate the factors associated with smartphone use time  Cross-sectional and secondary descriptive study  Self-administered questionnaire  No  “How often do you usually use your smartphone for each type of content?” including messengers, social media, games, videos/movies/TV, information-searching/web-surfing, and educational videosa  Likert scale (1 = never, 5 = very often)a  Child 
Park, 2021 19  To identify usage patterns associated with problematic smartphone use (PSU)  Cross-sectional study  Self-administered questionnaire  Yes-  “How often did your child use a smartphone on a typical day in the last month?”  Likert Scale  Parents 
        Korean-language Smartphone Overdependence Scale (S-scale)    0 = not at all, 1 = rarely, 7 = very frequently   
Enthoven, 2021 15  To investigate the association between smartphone use and refractive error  Cross-sectional population-based study  App Smartphone: Myopia app  No  No item-  No answer  Child’s smartphone 
          Application installed in the smartphone for 5 weeks to track usage time     
Poujol, 2022 20  To analyze the association between mobile phone screen exposure and cognitive health  Cross-sectional study  Self-administered questionnaire  No  How many minutes per day do you use your phone? For specific purposes (ie, gaming, email, messaging, social media)a  Low: less than 9 min per day, Medium: from 9 to 20 min per day  Parents and child 
            High: more than 20 min per daya   
Olivella, 2023 28  To describe the association between problematic mobile phone use and social traits, health and health-related behaviors  Cross-sectional study  Self-administered scale: Mobile-Related Experiences Questionnaire (CERM) (30)  Yes  Mobile-Related Experiences Questionnaire (CERM) (30)  Mobile-Related Experiences Questionnaire (CERM) (30)  Child 
Maurya, 2022 21  To examine the association between smartphone screen time and sleep problems  Cross-sectional and longitudinal study  Self-administered questionnaire  No  1-Do you have tour own mobile phone or have access to a family member’s mobile phone that you can use?  1-Yes, have own mobile/yes, can access family member’s/No  Child 
          2. What all do you do with mobile phone?  2.Phone call, SMS, money transaction, online shopping, listening to music, taking pictures, WhatsApp/Facebook, gaming, streaming, educational content, other   
          3. How much time did you spend on all of these in the last day?b  3-Number of hoursb   
Marin-Dragu, 2023 27  To analyze the various ways in which measured smartphone use was associated with mental health  Cross-sectional analysis  Smartphone app, PROSIT-Predicting Risks and Outcomes of Social Interactions  No  No items.  No answers. The app collected data on smartphone interactions, accelerometer, location, screen time activity, ambient noise and light, and connectivity  Child’s smartphone 
          Application installed for approximately 30 days to track use in background     
Shah, 2023 26  To assess the prevalence of mobile phone use  Cross-sectional study  Self-administered questionnaire  No  Questionnaire not specified or published by authors  Questionnaire not specified or published by authors  Parents 
Al-Amri, 2023 29  To assess the effect of smartphone addiction on cognitive function and physical activity  Cross-sectional study  Self-administered questionnaire and Smartphone Addiction Scale-Short Version (SAS-SV) (31)  Self-reported questionnaire (not validated) and SAS-SV (validated)  Self-reported daily smartphone usage time and number of years the child had owned a smartphonea  Number of hours and age  Child 
Goel, 2023 22  To assess the association between smartphone use and quality of sleep  Cross-sectional study  Self-administered questionnaire via WhatsApp  No  Questionnaire not specified or published by authors  Questionnaire not specified or published by authors  Child 
Fortunato, 2023 23  To establish categories of adolescents with homogeneous patterns of smartphone or social media use and assess psychosocial variables  Cross-sectional study  Self-administered questionnaire  No  Child asked to report the time (hours in a day) spent both on all mobile screen time activity (overall time spent on the smartphone) and on each social media app (Instagram, Facebook, TikTok, Snapchat, and Twitter) and WhatsAppa  Hours in a day  Child 
      *For secondary variable, Bergen Social Media Addiction Scale (BSMAS)         
Ikeda, 2024 24  To examinate the association between screen time, including smartphone screen time, and overweight/obesity  Cross-sectional study  Self-administered questionnaire  No  Asked participants for information on smartphone screen time and non-smartphone screen time per day on weekdays and weekendsa  Hours in a day  Child 
Tatar, 2023 25  To analyze the factors associated with insomnia  Cross-sectional study  Self-administered questionnaire online  No  Asked participants if they used their smartphone just before bedtimea  Yes, No  Child 

Self-report questionnaires generally directed children or parents to freely report their estimated time of smartphone use in a day or the last week. Only two of them18,19 presented a Likert scale to provide the answer. In all other studies, the answer was given in hours per day.

Two researchers used a self-developed application as a measuring instrument. Einthoven et al.15 did not use a questionnaire, but a monitoring application installed on the teenagers’ smartphones for five weeks. Similarly, Marin Dragu et al.27 used an application installed in the smartphone as a measuring instrument for 30 days. Both applications tracked usage time in the background.

Only two studies, by Olivella-Cirici et al.28 and Al-Amri et al.,29 used validated questionnaires to assess smartphone usage time. The primary purpose of both instruments, the Mobile-Related Experiences Questionnaire (CERM), in Spanish language,30 and the Smartphone Addiction Scale-Short Version,31 is to assess for smartphone addiction.

With the exception of the studies by Park and Park,19 Poujoul et al.,20 and Shah and Phadke,26 it was the children who completed the questionnaires. In the studies by Olivella-Cirici et al.19 and Shah and Phadke,26 the questionnaires were completed by the parents, whereas Poujoul et al20 collected responses from both children and parents.

In addition, Olivella-Cirici et al.28 and Goel et al.22 described a prevalence of smartphone usage at bedtime of 70%–80% and 90%, respectively.

On the other hand, the main objective of most of the articles was to assess the association of smartphone screen time with another variable, frequently obesity, sleep or mental health. Only the study by Shah et al.26 focused on the measurement of smartphone screen time. Specifically, it analyzed the age at acquisition of the first phone, daily frequency and duration of mobile phone use, and primary purpose of use (educational, entertainment, or communication). The study also assessed parental perceptions of the appropriate age for introducing the device attitudes toward the child’s use. The statistical analysis was performed using the χ2 and Fisher exact tests, and we defined statistical significance as P < .05.

Discussion

Our review, based on the available evidence, shows that most children and adolescents living in developed countries use screens for more than 2 h a day. Organizations such as the WHO, the AAP and the SAP have defined screen time at early ages as using these devices for more than 2 h a day. Still, the studies that support these recommendations are outdated, as most of them focused on television watching, without taking into account the use of multiple screens or the rise of the smartphone.8,9,13 In addition, because the range of devices is increasing, as is the purpose and duration of their use, an accurate assessment of screen time would have to include not only time, but also measures of quality of use, content and context.

In relation to this, almost 30% of the reviewed literature studied different age groups without segregation. The needs, content and duration of screen time should not be the same in preschool age as in adolescence, for example. The fact that researchers are beginning to include this variable as a determinant of health brings us closer to the existing problem, although the reported data are not very accurate due to the inadequate monitoring of screen time.

Despite the rise of the smartphone and the concern it is creating within the scientific community, although they try to include this variable as a determinant of health, almost a third of the available studies did not seek to measure the prevalence of smartphone use, but investigated it as a secondary, associated variable. It is not treated as an emerging and key determinant of health in our young. Only a minority of authors18,19,26 focused their research specifically on this objective, and even they rarely used validated measurement instruments. Of the 89 studies reviewed, only 7 employed standardized questionnaires to assess smartphone screen time, and in 6 of these cases, the primary aim was not to directly measure screen time but rather to evaluate broader aspects such as addiction, lifestyle habits or sedentary behavior. This highlights the scarcity of validated tools specifically designed for measuring smartphone screen time and the urgent need for their development in future research. Moreover, very few studies have examined the type of activity or content to which screen time is devoted. The use of current contents or features to which screen time is devoted is studied by few authors. Following the rise of social networks in recent years, some authors have included it in their work (WhatsApp, Snapchat, Instagram…) although with a vague and imprecise approach.18,23

Similarly, some authors are beginning to innovate in screen time measurement tools by installing applications on the smartphone itself and act in the background, tracking the activity.15,27 However, this measurement option does not take into account multiscreen use and is limited exclusively to the monitoring of the selected device.

Other works on the subject try to find sociodemographic characteristics that influence the increase in excessive smartphone use time. Rodrigues et al61,108 found that a low level of parental communication was associated with an increased probability of excessive screen time. Likewise, Olivella et al.28 and Song et al.18 reported a higher screen time in girls than in boys. In developing a measurement instrument, it would be interesting to take these sociodemographic factors into account and to focus on these target populations.

At the legislative level, some countries are beginning to take measures in the school setting by regulating the use of smartphones through internal policies.29 European countries such as Spain, France and the Netherlands have had internal rules in place for years. Currently, the responsibility lies with the school board, and most schools prohibit the use of phones in the school setting and establish penalties for adolescents.109 In Asia, the Chinese government has officially proposed limiting the use of cell phones by minors. The proposal advocates a “minor mode” in the manufacture of cell phones that will limit the time of use according to the age of the minor.30 In the United States, there is legislation that regulates the use of mobile telephones in the school setting. Under the Technology in Public Schools K-12 Act (CS/HB 379), which became effective July 1, 2023, section 1006.07(2)(f) of the Florida Statutes now states that “a student may not use a wireless telephone communication device during instructional time”.31 Awareness of the issue has gone further in the United States, with nearly one-third of the states suing Meta Platforms, claiming that their social networks Instagram and Facebook are addictive and harmful to children and adolescents and their use is associated with depression, anxiety and insomnia and interferes with education and daily life.32

However, it is difficult to establish appropriate health policies when the monitored health determinant, in this case, excessive smartphone use, is not measured effectively. The wide range of measures used and the limited agreement between the assessments themselves create a scientific gap on the correct measurement of screen time. In this regard, data on screen use, especially smartphones, available for Europe (national health surveys, Eurobarometer, etc) and the rest of the world do not allow for comprehensive surveillance because they do not differentiate between the type of device used (smartphone, computer, console, TV, etc.) and do not provide information on relevant aspects of use that could determine possible addiction in the future.

The main limitation of our review is that it does not include longitudinal studies. We only included cross-sectional studies with greater external validity that would allow extrapolation of the results to the target population. Although longitudinal studies on the impact of screens on the health of the pediatric population include questionnaires to assess screen use, including the use of mobile phones, these questionnaires are not aimed at extrapolating the pattern of use in the pediatric population (external validity), which was the objective of our review.

It is important to note that the source of information used can introduce bias: children tend to underestimate their screen time due to social desirability, recall issues, or, in the case of younger children, difficulties understanding the questions, whereas parents may overestimate it due to not accurately knowing their children’s behaviors. These limitations highlight the need for future research to include validated questionnaires and to focus on the development of standardized and validated tools for this purpose.

Another limitation is the heterogeneity of the studies included, which makes it difficult to synthesize the results. Although our initial intention was to perform a meta-analysis of the studies, this was not possible due to the heterogeneity of the data. In addition, the variation in the terminology used by the authors and the lack of consensus on the definition of screen time made the work difficult. Nevertheless, we were able to identify many common conclusions among the included studies.

This scoping review highlights the scientific gap in the measurement of smartphone screen time in the pediatric population. For public health policies to be applicable and relevant, the use of validated methodology is of the essence. Bani-Issa et al.,33 who used an appropriate instrument, were the authors that reported the highest usage time (up to 7 h/day), consistent with the current boom and lack of control. For usage patterns to be applicable to today’s society, it is especially important to create a measurement instrument that standardizes measurement and, therefore, the results of smartphone screen time in the pediatric population. In this way, existing problems will be correctly identified, allowing development of appropriate usage recommendations and guidelines.

Ethics approval

Not applicable.

Funding

This study was funded by the “Ministerio de Ciencia e Innovación” of the Government of Spain (ref.: PID2021-122272OB-I00) and by FEDER funds/European Regional Development Fund (ERDF) –a way to build Europe. The Group of Evaluation of Health Determinants and Health Policies of Universidad de Extremadura received support of Junta de Extremadura [grant number CTS063].

Declaration of competing interest

The authors declare no conflicts of interest.

Appendix A
Supplementary data

The following are Supplementary data to this article:

Icono mmc1.pdf

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