Información de la revista
Vol. 58. Núm. 4.
Páginas 364-375 (Abril 2003)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 58. Núm. 4.
Páginas 364-375 (Abril 2003)
Acceso a texto completo
Vacunaciones y trasplante de órgano sólido: revisión y recomendaciones
Vaccinations and solid-organ transplantation: review and recommendations
Visitas
11929
J. Iglesias Berenguea,
Autor para correspondencia
jiglesias.hmi@cs.vhebron.es

Correspondencia: Unidad de Cuidados Intensivos Pediátrica. Hospital Universitario Vall d'Hebron.
, J. López Espinosaa, M. Campins Martíb, J. Ortega Lópeza, F. Moraga Llopc
a Equipo de Trasplante Hepático Pediátrico. Hospital Universitario Vall d'Hebron. Barcelona. España
b Servicios de Medicina Preventiva y Epidemiología Hospital Universitario Vall d'Hebron. Barcelona. España
c Servicios de Pediatría. Hospital Universitario Vall d'Hebron. Barcelona. España
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas

Los receptores pediátricos de trasplante de órgano sólido tienen un alto riesgo de padecer diversas enfermedades infecciosas. Algunos niños no han recibido las vacunas recomendadas para su edad, antes del trasplante. Para reducir el riesgo de morbilidad y mortalidad de las enfermedades prevenibles mediante vacunación, es importante que los médicos que tratan a estos niños vigilen su estado vacunal. No hay consenso sobre el esquema de inmunización más apropiado para los receptores de trasplante de órgano sólido, por lo que se revisa la información disponible sobre la seguridad y la eficacia de las inmunizaciones, y se describen las estrategias para evitar las enfermedades prevenibles mediante vacunación en los niños receptores de trasplante de órgano sólido.

Palabras clave:
Vacunas Pediatría
Trasplante de órgano sólido
Inmunosupresión

Pediatric solid-organ transplant recipients are at high risk for various infectious diseases. Many children are not fully vaccinated before transplantation. To reduce the risk of morbidity and mortality from vaccine-preventable disease, physicians treating pediatric solid-organ transplant recipients should monitor the immunization status of the-se patients. Consensus on the most appropriate immunization schedule for solid-organ transplant recipients is lacking. Therefore, we provide a review of the currently available data on immunization safety and efficacy and describe strategies to avoid vaccine-preventable diseases in pediatric solid-organ transplant recipients.

Key words:
Vaccines
Pediatric
Solid-organ transplantation
Immunosuppression
El Texto completo está disponible en PDF
BibliografÍa
[1.]
P.K. Jaudes, L.J. Diamond.
Neglect of chronically ill children.
Am J Dis Child, 140 (1986), pp. 655-658
[2.]
C.M. Ginsburg, W. Andrews.
Orthotopic hepatic transplantation for unimmunized children: A paradox of contemporary medical care.
Pediatric Infect Dis J, 6 (1987), pp. 764-765
[3.]
S.L. Furth, A.M. Neu, E.K. Sullivan, G. Gensler, A. Tejani, B.A. Fivush.
A report of the North American Pediatric Renal Transplant Cooperative Study.
Pediatr Nephrol, 11 (1997), pp. 443-446
[4.]
CDC. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients.
Mmwr, 49 (2000), pp. 1-125
[5.]
C. De la Cámara R, Bischofberger, C. Bischofberger, M. Campins, E. Carrearas.
Inmunización postrasplante de progenitores hemopoyéticos: revisión y recomendaciones.
Med Clin (Barc), 110 (1998), pp. 146-156
[6.]
C. De la Cámara R, Bischofberger.
Comité Asesor de Vacunas de la Asociación Española de Pediatría. Calendario vacunal de la Asociación Española de Pediatría2003.
An Pediatr, 58 (2003), pp. 257-262
[7.]
N. Lee, R.H. Kobayashi.
Immunizations in the immunocompromised host.
Infections in Immunocompromised Infants and Children, pp. 741-747
[8.]
S.L. Kaplan.
Heart transplants: Infections in immunocompromised infants and children.
Infections in Immunocompromised Infants and Children, pp. 251-260
[9.]
T. Hernández, S. Matos.
Vacunaciones en niños en situaciones.
Vacunas 2000, pp. 119-130
[10.]
M. Campins, J. Batalla.
La vacunación de pacientes que requieren cuidados médicos continuados.
Manual de terapéutica médica, pp. 1129-1134
[11.]
K. Stark, M. Günther, C. Schönfeld, S.G. Tullius, U. Bienzle.
Immunisations in solid-organ transplant recipients.
[12.]
D. Huzly, S. Neifer, P. Reinke, K. Schröder, C. Schönfeld, T. Hofmann.
Routine immunizations in adult renal transplant recipients.
Transplantation, 63 (1997), pp. 839-845
[13.]
M. Burroughs, A. Moscona.
Immunization of pediatric solid organ transplant candidates and recipients.
Clin Infect Dis, 30 (2000), pp. 857-869
[14.]
W.C. Gruber.
Immunizatios in the immunocompromised host.
Clinical management of infections in inmunocompromised infants and children, pp. 511-535
[15.]
A.M. Neu, B.A. Fivush.
Recommended immunization practices for pediatric renal tranplant recipients.
Pediatr Transplant, 2 (1998), pp. 263-269
[16.]
P.S. Diaz, D. Au, S. Smith, M. Amylon, M. Link, S. Smith.
Lack of Transmission of the Live Attenuated Varicella Vaccine Virus to Immunocompromised Children After Immunization of Their Siblings.
Pediatrics, 87 (1991), pp. 166-170
[17.]
T.J. Mauch, S. Bratton, T. Myers, E. Krane, S.R. Gentry, C.E. Kashtan.
Influenza B virus infection in pediatric solid organ transplant recipients.
Pediatrics, 94 (1994), pp. 225-229
[18.]
D.H. Van Thiel.
Vaccination of patients with liver disease: Who, when, and how.
Liver Transpl Surg, 4 (1998), pp. 185-187
[19.]
P. Ljungman.
Immunization in the Immunocompromised Host.
Vaccines. 3.a ed, pp. 98-110
[20.]
D.A. Kelly, D. Mayer.
Liver Transplantationq.
Diseases of the liver and Biliary System in Children, pp. 293-312
[21.]
T.R. Welch, Q.W. Balistreri, S. Daniels.
Care of the child with a solid organ transplant: What is the role of the generalistα.
J Pediatr, 130 (1997), pp. 850-851
[22.]
Litofinter, (2001),
[23.]
G.V. Mazariegos, M. Green, J. Reyes, B. Nour, A. Tzakis, T.E. Starzl.
Rubella infection after orthotopic liver transplantation.
Pediatr Infect Dis J, 13 (1994), pp. 161-162
[24.]
N. Bakshi, J. Lawson, R. Hanson, C. Ames, H.V. Vinters.
Fatal mumps meningoencephalitis in a child with severe combined immunodeficiency after bone marrow transplantation.
J Child Neurol, 11 (1996), pp. 159-162
[25.]
S.L. Schulman, A. Deforest, B.A. Kaiser, M.S. Polinsky, H.J. Baluarte.
Response to measles mumps-rubella vaccine in children on dialysis.
Pediatr Nephrol, 6 (1992), pp. 187-189
[26.]
American Academy of Pediatrics, Committee on Infectious Diseases. Recommended Childhood Immunization Sche-dule-United States 2002.
Pediatrics, 109 (2002), pp. 162-164
[27.]
E.B. Rand, C.A. McCarthy, P.F. Whitington.
Measles vaccination after orthotopic liver trasnplantation.
J Pediatr, 123 (1993), pp. 87-89
[28.]
P. Palumbo, L. Hoyt, K. Demasio, J. Oleske, E. Connor.
Population-based study of measles and measles immunization in human immunodeficiency virus-infected children.
Pediatr Infect Dis J, 11 (1992), pp. 1008-1014
[29.]
S.C. Redd, L.E. Markowitz, S.L. Katz.
Measles vaccine.
Vaccines. 3.a ed, pp. 222-266
[30.]
SA. Plotkin.
Immunologic correlates of protection induced by vaccination.
Pediatr Infect Dis J, 20 (2001), pp. 63-75
[31.]
AAP Committee on Infectious Diseases. Poliomyelitis prevention: Recommendations for use of inactivated poliovirus vaccine and live oral poliovirus vaccine.
Pediatrics, 99 (1997), pp. 330-335
[32.]
A. Balloni, BM. Assael, L. Ghio, C. Pedrazzi, G. Nebbia, B. Gridelli.
Immunity to poliomyelitis, diphtheria and tetanus in pediatric patients before and after renal or liver transplantation.
Vaccine, 17 (1999), pp. 2507-2511
[33.]
IC. Kitai, S. King, A. Gafni.
An Economic Evaluation of Varicella Vaccine for Pediatric Liver and Kidney Transplant Recipients.
Clin Infect Dis, 17 (1993), pp. 441-447
[34.]
M. Donati, M. Zuckerman, A. Dhawan, N. Hadzic, N. Heaton, P. North-Lewis.
Response to varicella immunization in pediatric liver transplant recipients.
Transplantation, 70 (2000), pp. 1401-1404
[35.]
M. Broyer, MJ. Tete, G. Guest, MF. Gagnadoux, C. Rouzioux.
Varicella and zoster in children after kidney transplantation: Long-term results of vaccination.
Pediatrics, 99 (1997), pp. 35-39
[36.]
C. Nithichaiyo, V. Chongsrisawat, Y. Hutagalung, HL. Bock, Y. Poovorawa.
Immunogenicity and adverse effects of live attenuated varicella vaccine (Oka-strain) in children with chronic liver disease.
Asian Pac J Allergy Immunol, 19 (2001), pp. 101-105
[37.]
R. Giacchino, M. Marcellini, A. Timitilli, L. Degli-Innocenti, G. Losurdo, M. Palumbo.
Varicella vaccine in children requiring renal or hepatic transplantation.
Transplantation, 60 (1995), pp. 1055-1056
[38.]
A. Pandya, S. Wasfy, D. Hebert, UD. Allen.
Varicella-zoster infection in pediatric solid- organ transplant recipients: A hospital-based study in the prevaricella vaccine era.
Pediatr Transplant, 5 (2001), pp. 153-159
[39.]
SL. Furth, EK. Sullivan, AM. Neu, A. Tejuni, BA. Fivush.
Fivush BA. Varicella in the first year after renal transplantation: A report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS).
Pediatr Transplant, 1 (1997), pp. 37-42
[40.]
RS. McGregor, BJ. Zitelli, AH. Urbach, JJ. Malatack, JC. Gartner.
Varicella in Pediatric Orthotopic Liver Transplant Recipients.
Pediatrics, 83 (1989), pp. 256-261
[41.]
C. Feldhoff, HH. Balfour, RL. Simmons.
Varicella in children with renal transplants.
J Pediatr, 98 (1981), pp. 25-31
[42.]
I. Zamora, J.M. Simón, ME. Da Silva, AI. Piqueras.
Attenuated varicella virus vaccine in children with renal transplants.
Pediatr Nephrol, 8 (1994), pp. 190-192
[43.]
EA. Santiago-Delpín.
Varicella after kidney transplantation.
Pediatr Transplant, 2 (1998), pp. 244
[44.]
SL. Furth, BA. Fivush.
Varicella vaccination in pediatric kidney transplant candidates.
Pediatr Transplant, 6 (2002), pp. 97-100
[45.]
JM. Aguado, JA. Herrero, J. Gavalda, J. Torre-Cisneros, M. Blanes, G. Ruf.
Clinical presentation and outcome of tuberculosis in kidney, liver, and heart transplant recipients in Spain. Spanish Transplantation Infection Study Group, GESITRA.
Transplantation, 63 (1997), pp. 1278-1286
[46.]
F. Köseoglu, R. Emiroglu, H. Karakayali, N. Bilgin, M. Haberal.
Prevalence of Mycobacterial Infection in Solid Organ Trans-plant Recipients.
Transplant Proc, 33 (2001), pp. 1782-1784
[47.]
J. Muñiz.
Indicaciones de la vacuna BCG en nuestro medio.
Vacunas 2001, pp. 191-203
[48.]
CDC issues recommendations on the role of BCG vaccine in the prevention and Control of tuberculosis.
Am Fam Physician, 54 (1996), pp. 1115-1118
[49.]
DN. Gilbert, RC. Moellering, MA. Sande.
Antimicrobial Therapy, (2002),
[50.]
J. Mensa, JM. Gatell, MT. Jinénez de Anta, G. Prats, A. Domín-guez-Gil.
Editores Médicos, (2002),
[51.]
FA. Moraga Llop.
Prous Science, (1996),
[52.]
L. Ghio, C. Pedrazzi, BM. Assael, A. Panuccio, M. Foti, A. Edefonti.
Immunity to diphtheria and tetanus in a young population on a dialysis regimen or with a renal transplant.
J Pediatr, 130 (1997), pp. 987-989
[53.]
BU. Enke, A. Bokenkamp, G. Offiner, P. Bartmann, J. Brodehl.
Response to Diphtheria and tetanus booster vaccination in pediatric renal transplant recipients.
Transplantation, 64 (1997), pp. 237-241
[54.]
C. Pedrazzi, L. Ghio, A. Balloni, A. Panuccio, M. Foti, A. Edefonti.
Duration of immunity to diphtheria and tetanus in young kidney transplant patients.
Pediatr Transplant, 3 (1999), pp. 109-114
[55.]
MS. Sever, A. Yildiz, H. Eraksoy, S. Badur, D. Yüksel-Önel, B. Görcin.
Immune response toHaemophilus influenzaeType b vaccination in renal transplant recipients with well-functioning allografts.
Nephron, 81 (1999), pp. 55-59
[56.]
AM. Neu, HM. Lederman, BA. Warady.
Haemophilus influenza type b immunization in infants on peritoneal dialysis. Pediatric Peritoneal Dialysis Study Consortium.
Pediatr Nephrol, 10 (1996), pp. 84-85
[57.]
TJ. Dengler, N. Strnad, R. Zimmermann, C. Allers, BH. Markus, SV. Nessen.
Pneumococcal vaccination after heart and liver transplantation. Immune responses in immunosuppressed patients and in healthy controls.
Dtsch Med Wochenschr, 121 (1996), pp. 1519-1525
[58.]
M. Campins, R. Anoro, L. Callís, N. Pinart, MJ. Cruz, J. De Gracia.
Inmunogenicidad de la vacuna antineumocócica de 23 poli-sacáridos en niños con enfermedad renal crónica.
An EspPediatr, 52 (2000), pp. 220-240
[59.]
M. Campins, FA. Moraga.
Vacuna antineumocócica 23-valente.
La enfermedad neumocócica en el niño, pp. 87-104
[60.]
FA. Moraga, M. Campins, F. De Juan Martín.
Vacuna conjugada antineumocócica heptavalente.
La enfer-medad neumocócica en el niño, pp. 105-135
[61.]
SL. Furth, AM. Neu, M. Case, HM. Lederman, M. Steinhoff, B. Fivush.
Pneumococcal polysaccharide vaccine in children with chronic renal disease: A prospective study of antibody res-ponse and duration.
J Pediatr, 128 (1996), pp. 99-101
[62.]
R. Kazoncioglu, MS. Sever, D. Yüksel-Önel.
Immunization of renal transplant Recipients with pneumococcal polysaccharide vaccine.
Clin Transplant, 14 (2000), pp. 61-65
[63.]
TJ. Dengler, N. Strnad, I. Buhring, R. Zimmermann, O. Girgsdies, WE. Kubler.
Differential immune response to influenza and pneumococcal vaccination in immunosuppressed patients after heart transplantation.
Transplantation, 66 (1998), pp. 1340-1347
[64.]
RU. Sorensen, LE. Leiva, PA. Giangrosso.
Response to a heptava-lent conjugate Streptococcus pneumoniaevaccine in children with recurrent infections who are unresponsive to the polysac-charide vaccine.
Pediatr Infect Dis J, 17 (1998), pp. 685-691
[65.]
FA. Moraga.
Avances en vacunas y enfermedad invasora en el niño. Vacuna neumocócica conjugada heptavalente.
Rev Esp Quimioterap, 14 (2001), pp. 319-330
[66.]
TM. McCashland, LC. Preheim, MJ. Gentry-Nielsen.
Pneumococ-cal Vaccine Response in Cirrhosis and Liver Transplantation.
J Infect Dis, 181 (2000), pp. 757-760
[67.]
I. Quintini, A. Velardi, S. Le Moli.
Antibacterial polysaccharide antibody deficiency After allogeneic bone marrow transplanta-tion.
J Clin Immunol, 10 (1990), pp. 160-166
[68.]
EB. Kacsmarski, M. Günther, R. Neuhaus, P. Reinke, K. Schröder, S. Linnig.
Immunogenicity and Safety of Hepatitis A Vaccine in Liver and Renal Transplant Recipients.
J Infect Dis, 180 (1999), pp. 2014-2017
[69.]
K. Strak, M. Günther, R. Neuhaus, P. Reinke, K. Schröder, S. Linnig.
Immunogenicity and Safety of Hepatitis A Vaccine in Liver and Renal Transplant Recipients.
J Infect Dis, 180 (1999), pp. 2014-2017
[70.]
M. Günther, K. Stark, R. Neuhaus, P. Reinke, K. Schröder, U. Bienzle.
Rapid decline of antiboidies after hepatitis A immunization in liver and renal transplant recipients.
Transplantation, 71 (2001), pp. 477-479
[71.]
M. Arslan, RH. Wiesner, JJ. Poterucha Q, NN. Zein.
Safety and effi-cacy of hepatitis A vaccination in liver transplantation reci-pients.
Transplantation, 72 (2001), pp. 272-276
[72.]
H. Jiang, M. Kobayashi.
Differences between cyclosporin A and tacrolimus in organ transplantation.
Transplant Proc, 31 (1999), pp. 1978
[73.]
M. Arslan, RH. Wiesner, JJ. Poterucha, JB. Gross, NN. Zein.
Hepa-titis A antibodies in liver transplant recipients: Evidence for loss of immunity posttransplantation.
Liver Transplant, 6 (2000), pp. 191-195
[74.]
MG. Pessoa, NA. Terrault, LD. Ferrell.
Hepatitis after liver transplantation: The role of the known and unknown viruses.
Liver Transpl Surg, 4 (1998), pp. 461-468
[75.]
DP. Greenbreg, CM. Vadheim, VK. Wong.
Comparative safety and immunogenicity of two recombinant hepatitis B vaccines given to infants at two, four and six months of age.
Pediatr Infect Dis J, 15 (1996), pp. 590-596
[76.]
P. Duca, JM. Del Pont, D. D’Agostino.
Successful Immune Res-ponse to a Recombinant Hepatitis B Vaccine in Children After Liver Transplantation.
J Pediatr Gastroenterol Nutr, 32 (2001), pp. 168-170
[77.]
EM. Sokal, L. Ulla, JB. Otte.
Hepatitis B vaccine response before and after transplantation in 55 extrahepatic biliary atresia chil-dren.
Dig Dis Sci, 37 (1992;), pp. 1250-1252
[78.]
M. Arlan, RH. Wiesner, C. Sievers, K. Egan, NN. Zein.
Double-dose accelerated hepatitis B vaccine in patients with end-stage liver disease.
Liver Transplant, 7 (2001), pp. 314-320
[79.]
P. Van Damme.
Vacuna antihepatitis B. Nuevos adyuvantes y nuevas pautas.
Vacunas 2001, pp. 181-189
[80.]
SH. Engler, PW. Sauer, M. Golling, EA. Klar, C. Benz, W. Stremmel.
Immunogenicity of two accelerated hepatitis B vaccina-tion protocols in liver transplant candidates.
Eur J Gastroente-rol Hepatol, 13 (2001), pp. 363-367
[81.]
B. Kallinowski, C. Benz, L. Buchholz, W. Stremmel.
Accelerated schadule of hepatitis B vaccination in liver transplant candida-tes.
Transplant Proc, 30 (1998), pp. 797-799
[82.]
C. Loinaz, JR. De Juanes, EM. González.
Hepatitis B vaccination results in 140 liver transplant recipients.
Hepatogastroentero-logy, 44 (1997), pp. 235-238
[83.]
P. Lykavieris, M. Fabre, J. Yvart.
HBV infection in pediatric liver transplantation.
J Pediatr Gastroenterol Nutr, 16 (1993), pp. 321-327
[84.]
A. Sánchez-Fueyo, A. Rimola, L. Grande.
Hepatitis B immuno-globulin discontinuation followed by hepatitis B virus vaccina-tion: A new strategy in the prophylaxis of hepatitis B virus recu-rrence after liver transplantation.
Hepatology, 31 (2000), pp. 495-501
[85.]
A. Duchini, RM. Hendry, DC. Redfield, PJ. Pockros.
Influenza infection in patients before and after liver transplantation.
Liver Transplant, 6 (2000), pp. 531-542
[86.]
SL. Furth, AM. Seu, SA. McColley, B. Case, M. Steinhoff, B. Fivus.
Immune response to influenza vaccination in children with renal disease.
Pediatr Nephrol, 9 (1995), pp. 566-568
[87.]
FG. Hayden.
Prevention and treatment of influenza in immuno-compromised patients.
Am J Med, 102 (1997), pp. 55-60
[88.]
TJ. Mauch, NA. Crouch, DK. Freese, EA. Braunlin, DL. Dunn, CE. Kashtan.
Antibody response of pediatric solid organ trans-plant recipients to immunization against influenza virus.
J Pediatr, 127 (1995), pp. 957-960
[89.]
DR. Mack, SA. Chartrand, EI. Rubby, DL. Antonson, BW. Shaw, TG. Heffron.
Influenza vaccination following liver transplanta-tion in children.
Liver Transpl Surg, 2 (1996), pp. 431-437
[90.]
V. Edvarsson, J. Flynn, A. Deforest.
Effective immunization against influenza in pediatric renal transplant recipients.
Clin Transplant, 10 (1996), pp. 556-560
[91.]
AI. Sanchez-Fructuoso, D. Prats, P. Naranjo, C. Fernández-Pérez, MJ. González, A. Mariano.
Influenza virus immunization effectivity in kidney transplant patients subjected to two diffe-rent triple-drug therapy immunosuppression protocols. My-cophenolate versus Azathioprine.
Transplantation, 69 (2000), pp. 436-439
[92.]
EA. Blumberg, C. Albano, T. Pruett.
The immunogenicity of influenza virus vaccine in solid organ transplant recipients.
Clin Infect Dis, 22 (1996), pp. 295-302
[93.]
RB. Belshe, PM. Mendelman, J. Treanor, J. King, WC. Gruber, P. Pie-dra.
The efficacy of live attenuated, cold-adapted, triva-lent, intranasal influenzavirus vaccine in children.
N Engl J Med, 338 (1998), pp. 1405-1412
[94.]
FA. Moraga Llop, M. Campins Martí.
Importancia de la gripe en el niño. Vacuna antigripal intranasal: ¿otra inmunización siste máticaα.
An Esp Pediatr, 53 (2000), pp. 299-304
[95.]
DC. Molrine, PL. Hibberd.
Vaccines for transplant recipients.
Infect Dis Clin North Am, 15 (2001), pp. 273-305
Copyright © 2003. Asociación Española de Pediatría
Idiomas
Anales de Pediatría
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?