TY - JOUR T1 - Anti-tissue transglutaminase antibodies not related to gluten intake JO - Anales de Pediatría (English Edition) T2 - AU - Garcia-Peris,Mónica AU - Donat Aliaga,Ester AU - Roca Llorens,María AU - Masip Simó,Etna AU - Polo Miquel,Begoña AU - Ribes Koninckx,Carmen SN - 23412879 M3 - 10.1016/j.anpede.2018.01.011 DO - 10.1016/j.anpede.2018.01.011 UR - https://analesdepediatria.org/en-anti-tissue-transglutaminase-antibodies-not-related-articulo-S2341287918301601 AB - IntroductionAnti-tissue transglutaminase antibodies (tTG) have high specificity for coeliac disease (CD). However, positive anti-tTG antibodies have been described in non-coeliac patients. AimTo assess positive anti-tTG antibodies not related to gluten intake. Patients and methodsRetrospective review and follow up conducted on patients with suspected CD (increase anti-tTG levels and gastrointestinal symptoms) but with atypical serology results, positive anti-tTG with gluten free diet and a decrease in anti-tTG levels despite gluten intake. ResultsA total of 9 cases were reviewed in which 5 cases had Marsh 3 involvement in the initial biopsy, and were diagnosed with CD (Group A). They began a gluten free diet and also a cow's milk protein (CMP) free diet because of their nutritional status. When CMP was re-introduced, anti-tTG increased, and returned to normal after the CMP was withdrawn again. The other 4 patients had a normal initial biopsy (Group B). Gluten was not removed from their diet, but they started a CMP free diet because a non IgE mediated CMP allergy was suspected. Symptoms disappeared, and anti-tTG was normal after CMP free diet with gluten intake. All the patients had susceptibility haplotype HLA DQ2/DQ8. ConclusionsCMP ingestion after an exclusion diet can induce an increase in anti-tTG in some coeliac subjects. CMP can produce this immune response if there were no gluten transgressions. This response has also been observed in non-IgE mediated CMP allergy patients with the susceptibility haplotype HLA DQ2/DQ8. ER -